Abstract:Optimal clinical trial design based on a dichotomous Markov-chain mixed-effect sleep model. Pharmacokinetics and Pharmacodynamics, 41(6)
Journal of
Abstract.Objectives: D-optimal designs for discrete-type responses have been derived using generalized linear mixed models, simulation based methods and analytical approximations for computing the Fisher information matrix (FIM) of non-linear mixed effect models with homogeneous probabilities over time. In this work, D-optimal designs using an analytical approxima… Show more
This study illustrates the application of model simplification processes to an existing model for MTX RBC PK. The same techniques illustrated in our study may be adopted by other studies with similar interest.
This study illustrates the application of model simplification processes to an existing model for MTX RBC PK. The same techniques illustrated in our study may be adopted by other studies with similar interest.
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