Optimal blood pressure for the minimum all-cause mortality in Chinese ESRD patients on maintenance hemodialysis

Wang, Tao; Yang, Li; Wu, Haibo; Chen, Hua; Zhang, Yan; Zhou, Huanjiao Jenny; Li, Hang

doi:10.1042/bsr20200858

Cited by 13 publications

(15 citation statements)

References 31 publications

(39 reference statements)

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“…This increase in BP which can be due to fluid overload, over activity of renin angiotensin system, erythropoietin administration and enhanced stimulation of the sympathetic nervous system. Our results are similar to the findings of Wang et al, 13 who reported a mean SBP of 143.2 ± 32.7mmHg and mean DBP of 79.0 ± 15.9 mmHg among hemodialysis patients.…”

Section: Discussionsupporting

confidence: 92%

Impact of Enhanced Lipid Peroxidation on Carotid Artery Intima Media Thickness Ratio in Patients Receiving Maintenance Hemodialysis

Rehman

Mahboob

Kumar

et al. 2022

PAFMJ

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Objective: To determine the impact of increased lipid peroxidation on carotid intima media thickness ratio in patients receiving maintenance hemodialysis. Study Design: Comparative prospective study. Place and Duration of Study: Jinnah Post Graduate Medical Center Karachi in collaboration with University of Karachi, Pakistan, from Jan to Dec 2018. Methodology: The hemodialysis patients were selected from the dialysis center where as the controls were recruited from normal healthy population. The cases taken were receiving maintenance hemodialysis thrice a week. Doppler ultrasonography technique was employed to detect the intima media thickness (IMT) ratio of common carotid artery of study subjects as well as controls. Lipid peroxidation was detected by serum oxidized LDL (ox-LDL) levels. Results: The mean of right common carotid artery of group A samples was 0.45 ± 0.04 mm, left common carotid artery was 0.42 ± 0.01mm, and mean intima thickness was 0.43 ± 0.02 mm, the mean of right common carotid artery in group B was 0.93 ± 0.09 mm and mean of left common carotid in group B was 1.07 ± 0.14 mm and mean intima thickness of group B samples was 1.0 ± 0.09 mm. In group A mean Ox-LDL was 24.87 ± 5.23 U/ml while in group C samples mean Ox-LDL was 73.77 ± 6.77 U/ml. Conclusion: Lipid peroxidation is much enhanced in patients on maintenance hemodialysis and leads to an increased carotid artery intima media thickness ratio which is a sign of development of atherosclerosis. This study will help the nephrologists in determining the causes..................

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Section: Discussionsupporting

confidence: 92%

Impact of Enhanced Lipid Peroxidation on Carotid Artery Intima Media Thickness Ratio in Patients Receiving Maintenance Hemodialysis

Rehman

Mahboob

Kumar

et al. 2022

PAFMJ

View full text Add to dashboard Cite

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“…15 Thus, the levels of MDA production can be used as a biomarker to estimate the level of OS. 16 When OS occurs, it triggers oxidation and subsequent damage to biological macromolecules, causing severe tissue damage. 17 Oxidative degradation of lipids yields MDA.…”

Section: P R O V I S I O N a L L Ymentioning

confidence: 99%

Correlation between Serum Malondialdehyde levels and prevalence of cardiovascular disease in Haemodialysis treated patients

2022

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Objectives: To investigate the role of serum malondialdehyde as a diagnostic biomarker of free radical production and cardiovascular disease in patients treated with maintenance haemodialysis. Method: The case-control study was conducted in the Department of Biochemistry, Basic Medical Sciences Institute (BMSI) of the Jinnah Postgraduate Medical Centre (JPMC), Karachi, and the JPMC Nephrology ward from January 12, 2018, to January 15, 2019, and comprised patients receiving haemodialysis as the cases and healthy controls. Blood samples were obtained from all the subjects for checking the level of serum malondialdehyde. Doppler ultrasonography was employed to detect the intima media thickness ratio of the common carotid artery of all the subjects. Data ws analysed using SPSS 23. Results: Of the 90 subjects, 45(50%) each were cases and controls. There were significant differences in mean values related to age, body mass index and blood pressure between the groups. A statistically significant rise was seen in serum malondialdehyde and carotid artery intima media thickness ratio in the cases compared to the controls (p<0.05). Conclusion: Serum malondialdehyde was found to be significantly raised in haemodialysis patients compared to the healthy controls. Key Words: Malondialdehyde, Haemodialysis, Cardiovascular disease, Oxidative stress, Free radicals.

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“…Cardio-cerebrovascular mortality is the main component of all-cause mortality in MHD patients, followed by infectious diseases and malignancies [30] . In this study, the 3-year cardio-cerebrovascular mortality rates between the two groups was not P r e p r i n t significant.…”

Section: Discussionmentioning

confidence: 99%

Soluble α-Klotho as a potential predictor of all-cause mortality in Chinese maintenance hemodialysis patients

et al. 2022

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IntroductionThis study aimed to clarify the potential association of serum soluble α-klotho levels with all-cause mortality in Chinese patients on maintenance hemodialysis (MHD).Material and methodsThe present study is a single -center prospective cohort study. It comprised 134 MHD patients which were divided into two groups according to the median level of serum α -klotho: 68 patients representing the low soluble α-klotho group (< 1.15 ng/ml and equivalent to 1.15 ng/ml) and 66 patients representing the high soluble α -klotho group (>1.15 ng/ml). These patients were followed up for 36 months. The three-year all-cause mortality rate, overall survival (OS) and cardio-cerebrovascular mortality were observed. The potential risk factors of all-cause mortality in MHD patients were investigated by Cox regression models.ResultsThe 3-year all-cause mortality rates in low soluble α-klotho group were significantly higher than those in high soluble α-klotho group (33.82% vs. 16.67%, P=0.039). The difference of the 3-year cardio-cerebrovascular mortality rates between the two groups was non-significant (26.47% vs. 15.15%, P=0.107). The Kaplan-Meier analysis showed that the differences in the rates of OS and cardio-cerebrovascular death free survival between the two groups were significantly different (all P<0.05). The Cox regression analyses revealed that low soluble α-klotho level was an independent predictor of all-cause mortality in MHD patients after adjusting for potential confounding factors.ConclusionsLow serum soluble α-klotho levels was associated with increased risk of all-cause mortality in Chinese MHD patients.

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Optimal blood pressure for the minimum all-cause mortality in Chinese ESRD patients on maintenance hemodialysis

Cited by 13 publications

References 31 publications

Impact of Enhanced Lipid Peroxidation on Carotid Artery Intima Media Thickness Ratio in Patients Receiving Maintenance Hemodialysis

Impact of Enhanced Lipid Peroxidation on Carotid Artery Intima Media Thickness Ratio in Patients Receiving Maintenance Hemodialysis

Correlation between Serum Malondialdehyde levels and prevalence of cardiovascular disease in Haemodialysis treated patients

Soluble α-Klotho as a potential predictor of all-cause mortality in Chinese maintenance hemodialysis patients

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