Optimal baker's yeast production in extended fed-batch culture by using a computer coupled pilot fermenter

Ramírez, Antonio Avalos; Durand, Annie; Blachère, H

doi:10.1007/bf00133433

Cited by 7 publications

(2 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Blanchere/Station de Génie Microbiologique 1981 Ramirez et al (1981) Computer control of continuous processes with additional nutrient feeds and pH control using novel on-line sensors for biomass and glucose Not given Hatch/Maryland 1981Hatch (1982 Computer control of DO via agitation and oxygen gas flow to minimize operating costs…”

Section: Saccharomyes Cerevisiaementioning

confidence: 99%

Bioprocess monitoring and computer control: Key roots of the current PAT initiative

Junker

Wang

2006

Biotech & Bioengineering

113

View full text Add to dashboard Cite

This review article has been written for the journal, Biotechnology and Bioengineering, to commemorate the 70th birthday of Daniel I.C. Wang, who served as doctoral thesis advisor to each of the co-authors, but a decade apart. Key roots of the current PAT initiative in bioprocess monitoring and control are described, focusing on the impact of Danny Wang's research as a professor at MIT. The history of computer control and monitoring in biochemical processing has been used to identify the areas that have already benefited and those that are most likely to benefit in the future from PAT applications. Past applications have included the use of indirect estimation methods for cell density, expansion of on-line/at-line and on-line/in situ measurement techniques, and development of models and expert systems for control and optimization. Future applications are likely to encompass additional novel measurement technologies, measurements for multi-scale and disposable bioreactors, real time batch release, and more efficient data utilization to achieve process validation and continuous improvement goals. Dan Wang's substantial contributions in this arena have been one key factor in steering the PAT initiative towards realistic and attainable industrial applications.

show abstract

Section: Saccharomyes Cerevisiaementioning

confidence: 99%

Bioprocess monitoring and computer control: Key roots of the current PAT initiative

Junker

Wang

2006

Biotech & Bioengineering

113

View full text Add to dashboard Cite

show abstract

“…Shimizu (1993) has stressed the vital role which these models play in optimization and reviewed the use of this approach in batch, fed-batch and continuous processes for biomass and metabolites. This approach with appropriate on-line sensors and suitable model programs has been used to optimize bakers' yeast production (Ramirez et al, 1981;Shi et al, 1989), an industrial antibiotic process and lactic acid production (Shi et al, 1989).…”

Section: Process Controlmentioning

confidence: 99%