Optimal Anthropometric Indicators and Cut Points for Predicting Metabolic Syndrome in Chinese Patients with Type 2 Diabetes Mellitus by Gender

Abstract

Purpose The best predictors and cut points for metabolic syndrome (MetS) in Chinese patients with type 2 diabetes (T2DM) were determined by comparing six anthropometric measures: body mass index (BMI), triglyceride-glucose (TyG), the product of TyG and waist-to-hip ratio (TyG-WHpR), the product of TyG and waist-to-height ratio (TyG-WHtR), the product of TyG and waist circumference (TyG-WC), and the product of TyG and body mass index (TyG-BMI). Patients and Methods Sixteen hundred and sixty-five adult patients with T2DM were collected, and the ability and cut points of each index to predict MetS were compared by plotting the receiver operating characteristic (ROC) curve and calculating the area under the curve (AUC) values. Then, logistic regression analysis was used to adjust for confounders, including adjustment for menopause in women, to obtain the odds ratio (OR) and 95% confidence interval (CI). Results MetS was present in 71.60% of T2DM patients, 75.00% of men, and 67.02% of women. BMI was the best predictor of MetS in men with T2DM (AUC = 0.8646, 95% CI: 0.8379–0.8912), with a cut point of 24.5500 kg/m 2 (specificity: 0.7714; sensitivity: 0.7533), and TyG-WC was the best predictor of MetS in women with T2DM (AUC = 0.8362, 95% CI: 0.8034–0.8690), with a cut point of 154.1548 (specificity: 0.7455; sensitivity: 0.8076). Conclusion The best predictor of MetS in adults with T2DM is BMI with a cut point of 24.5500 kg/m 2 for men and TyG-WC with a cut point of 154.1548 for women.

Assessing the predictive value of insulin resistance indices for metabolic syndrome risk in type 2 diabetes mellitus patients

“…Mao et al conducted a study aiming to identify the optimal predictors and cut-off points for Metabolic Syndrome (MetS) among Chinese adults with Type 2 Diabetes Mellitus (T2DM). Their findings indicated that TyG-WC was the most effective predictor of MetS among women, while BMI emerged as the best predictor for both genders combined 35 . In contrast, our study revealed that TyG-WC was the superior predictor of MetS for both women and men.…”