Optically buffered Jones-matrix-based multifunctional optical coherence tomography with polarization mode dispersion correction

Hong, Young-Joo; Makita, Shuichi; Sugiyama, Satoshi; Yasuno, Yoshiaki

doi:10.1364/boe.6.000225

Cited by 13 publications

(6 citation statements)

References 46 publications

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“…The simulation results substantiate experimental observations that high-coherence operation of FDML lasers requires low residual intracavity dispersion, and that the smallest linewidths down to a few pm are obtained for non-PM configurations with polarization insensitive SOA. The developed numerical model can also be of general relevance for tunable lasers which use external fiber delay spools to increase the wavelength sweep speed in applications such as OCT [49,50].…”

Section: Discussionmentioning

confidence: 99%

Efficient simulation of the swept-waveform polarization dynamics in fiber spools and Fourier domain mode-locked (FDML) lasers

Jirauschek

Huber

2017

J. Opt. Soc. Am. B

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We present a theoretical model and its efficient numerical implementation for the simulation of wavelength-swept waveform propagation in fiber systems such as Fourier domain mode-locked (FDML) lasers, fully accounting for the polarization dynamics in fiber spools and further polarization dependent optical components in the setup. This approach enables us to perform long-time simulations of the FDML laser dynamics over more than 100000 cavity roundtrips, as required for some FDML configurations to ensure convergence to the steady state operating regime. The model is validated against experimental results for single propagation through a fiber spool and for stationary FDML operation. The polarization dynamics due to the fiber spool, inducing polarization-mode dispersion, bending birefringence as well as cross-phase modulation, and other optical components such as the Faraday-rotating mirror used for polarization compensation is thoroughly investigated.

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Section: Discussionmentioning

confidence: 99%

Efficient simulation of the swept-waveform polarization dynamics in fiber spools and Fourier domain mode-locked (FDML) lasers

Jirauschek

Huber

2017

J. Opt. Soc. Am. B

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“…2,5,274 To study complex anisotropic tissues possessing microscopic fibrous structures, including collagen fibers and nerve fibers, a conventional OCT was improved by enabling measurements of signal polarization characteristics, which is the PS-OCT. 2,5,9,15,21,22,61,62,66,67,103,129,132,163,202,[256][257][258][259][260]268 In-depth measurements of Stokes parameters allow for determination of tissue birefringence (phase retardation), dichroism (diattenuation), and optic-axis orientation. Advanced PS-OCT systems give the possibility for tissue imaging by measurements of a full Jones matrix 103,202,239,241,242 or Mueller matrix 61,62,67,202,239 for each pixel, as well as representing results of imaging in the form of the Poincaré sphere. 67,202,239 In the majority of studies by PS-OCT, the criterion of pathology in tissue is a measured decrease in tissue macroscopic birefringence.…”

Section: Polarization-sensitive Optical Coherence Tomographymentioning

confidence: 99%

Polarized light interaction with tissues

2016

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This tutorial-review introduces the fundamentals of polarized light interaction with biological tissues and presents some of the recent key polarization optical methods that have made possible the quantitative studies essential for biomedical diagnostics. Tissue structures and the corresponding models showing linear and circular birefringence, dichroism, and chirality are analyzed. As the basis for a quantitative description of the interaction of polarized light with tissues, the theory of polarization transfer in a random medium is used. This theory employs the modified transfer equation for Stokes parameters to predict the polarization properties of single- and multiple-scattered optical fields. The near-order of scatterers in tissues is accounted for to provide an adequate description of tissue polarization properties. Biomedical diagnostic techniques based on polarized light detection, including polarization imaging and spectroscopy, amplitude and intensity light scattering matrix measurements, and polarization-sensitive optical coherence tomography are described. Examples of biomedical applications of these techniques for early diagnostics of cataracts, detection of precancer, and prediction of skin disease are presented. The substantial reduction of light scattering multiplicity at tissue optical clearing that leads to a lesser influence of scattering on the measured intrinsic polarization properties of the tissue and allows for more precise quantification of these properties is demonstrated.

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“…Separating the received light in each polarization, the measurement of the birefringence of the sample is possible. This technique combined with OCT, called polarized sensitive OCT (PS-OCT) microscopy, was used to observe retardance in biological tissues such as coronary arteries where the contrast arises from collagen fibers in the coronary walls or in the fibrous cap of a thrombus [46,47], in retinal imaging where the intracellular structure of the melanosomes in the retinal pigment epithelium depolarize the backscattered light [48,49], and in white matter of mouse brains where lipids with MBP create an anisotropic structure [19]. The dependence of white-matter birefringence on its orientation helped provide a ground truth when correlating with other imaging techniques such as diffusion tensor imaging (DTI) via magnetic resonance [50].…”

Section: Birefringencementioning

confidence: 99%

A Review of Intrinsic Optical Imaging Serial Blockface Histology (ICI-SBH) for Whole Rodent Brain Imaging

2019

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In recent years, multiple serial histology techniques were developed to enable whole rodent brain imaging in 3-D. The main driving forces behind the emergence of these imaging techniques were the genome-wide atlas of gene expression in the mouse brain, the pursuit of the mouse brain connectome, and the BigBrain project. These projects rely on the use of optical imaging to target neuronal structures with histological stains or fluorescent dyes that are either expressed by transgenic mice or injected at specific locations in the brain. Efforts to adapt the serial histology acquisition scheme to use intrinsic contrast imaging (ICI) were also put forward, thus leveraging the natural contrast of neuronal tissue. This review focuses on these efforts. First, the origin of optical contrast in brain tissue is discussed with emphasis on the various imaging modalities exploiting these contrast mechanisms. Serial blockface histology (SBH) systems using ICI modalities are then reported, followed by a review of some of their applications. These include validation studies and the creation of multimodal brain atlases at a micrometer resolution. The paper concludes with a perspective of future developments, calling for a consolidation of the SBH research and development efforts around the world. The goal would be to offer the neuroscience community a single standardized open-source SBH solution, including optical design, acquisition automation, reconstruction algorithms, and analysis pipelines.

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Optically buffered Jones-matrix-based multifunctional optical coherence tomography with polarization mode dispersion correction

Cited by 13 publications

References 46 publications

Efficient simulation of the swept-waveform polarization dynamics in fiber spools and Fourier domain mode-locked (FDML) lasers

Efficient simulation of the swept-waveform polarization dynamics in fiber spools and Fourier domain mode-locked (FDML) lasers

Polarized light interaction with tissues

A Review of Intrinsic Optical Imaging Serial Blockface Histology (ICI-SBH) for Whole Rodent Brain Imaging

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