Optically Active Nanomaterials for Bioimaging and Targeted Therapy

Abstract

Non-invasive tracking for monitoring the selective delivery and transplantation of biotargeted agents in vivo has been employed as one of the most effective tools in the field of nanomedicine. Different nanoprobes have been developed and applied to bioimaging tissues and the treatment of diseases ranging from inflammatory and cardiovascular diseases to cancer. Herein, we will review the recent advances in the development of optics-responsive nanomaterials, including organic and inorganic nanoparticles, for multimodal bioimaging and targeted therapy. The main focus is placed on nanoprobe fabrication, mechanistic illustrations, and diagnostic, or therapeutical applications. These nanomedicine strategies have promoted a better understanding of the biological events underlying diverse disease etiologies, thereby facilitating diagnosis, illness evaluation, therapeutic effect, and drug discovery.

Advanced Biomimetic Nanomaterials for Non-invasive Disease Diagnosis

“…(4) Photoacoustic imaging (PAI) is a recently developed, non-invasive, and non-ionizing imaging method based on light and sound. PAI has great potential for application in nanomedicine (Yang et al, 2019). 5PET is a well-known, highly sensitive, and non-invasive imaging method that can achieve quantitative analysis and is not limited by tissue penetration.…”

“…Photoacoustic imaging is a recently developed technique that provides non-invasive and non-ionizing imaging based on light and sound. PAI has significant application potential in the field of nanomedicine (Yang et al, 2019). The photoacoustic signal is the ultrasonic signal generated by the light absorption of a biological tissue under laser irradiation.…”

Cancer nanotheranostics in the second near‐infrared window

“…These nanotheranostic platforms are usually composed of nanomaterials in both the diagnostic and therapeutic compartments that are responsive to external stimuli, such as light, heat, and sound for flexible controllability, to produce detectable signals and to enable controllable treatments 3 . Among these stimuli, light is the most widely used stimulus, due to its high spatiotemporal precision, easy manipulation, and high specificity 4 …”

Nanotheranostics With the Combination of Improved Targeting, Therapeutic Effects, and Molecular Imaging

“…Current cancer therapies may not achieve the optimum prognosis. Thus, effective and innovative targeted therapies are required ( Leach et al, 2016 ; Yang et al, 2019 ). Moreover, single-target drug carriers may be unsatisfactory for selective and effective therapy.…”