Optical Systems for <i>in Vivo</i> Molecular Imaging of Cancer

Sokolov, Konstantin V.; Aaron, Jesse; Hsu, Betsy; Nida, Dawn; Gillenwater, Ann M.; Follen, Michele; MacAulay, Calum; Adler‐Storthz, Karen; Korgel, Brian A.; Descour, Michael R.; Pasqualini, Renata; Arap, Wadih; Lam, Wan L.; Richards‐Kortum, Rebecca

doi:10.1177/153303460300200602

Cited by 195 publications

(145 citation statements)

References 85 publications

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“…Metal nanoparticles are outstanding in bio-sensing due to their SPR, optical properties and reduced size in nanoranges [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]. New approach for the sensing of bio-molecules using fluorescence intensity quenching measurements have special advantages like highly sensitive, noninvasive and cost effective [1,[20][21][22].…”

mentioning

confidence: 99%

Fluorescence Quenching of b-Casein by Silver Nanoparticles and Copper Nanoparticles in Presence of Sugars: A Quantitative Exploration

Vasumathi¹,

Santhanalakshmi²

2018

Asian J. Chem.

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INTRODUCTIONInvention of non-invasive in vivo biosensors is today's necessity in diagnostics, medical analysis and therapy [1,2]. Detection and estimation of sugars in biological systems attract the attention of medical engineers. When protein-carbohydrate interactions are studied and established in presence of silver and copper nanoparticles, new immunotherapeutic strategies may be discovered in the treatment of malignant diseases [3]. In this paper the studies on the interaction of silver nanoparticles (AgNP) and copper nanoparticles (CuNP) with milk protein, β-casein (BCA) is quantitatively described using fluorescence quenching measurements. The interaction studies between the protein and the nanoparticles (Pro-NP) are extensively studied in presence of various monosaccharide and disaccharide sugars like glucose, fructose, galactose, sucrose, maltose and lactose. The protein β-casein (BCA) exhibits a strong fluorescence emission, which is sensitive to active quenchers. Metal nanoparticles like copper nanoparticles and silver nanoparticles with enhanced and unique properties are reported to quench protein fluorescence appreciably. In the present work, the fluorescence quenching effects of metal nanoparticles on the protein fluorescence are extensively studied in presence of various sugar molecules. This may play a significant role in the sensing applications of sugar molecular systems in the presence of metal nanoparticles. β-Casein is used as fluorophore and sugar molecular systems like sucrose, maltose, fructose, lactose, galactose and glucose are chosen as quenchers and the protein-sugar interactions are arrived from fluorescence quenching results in the presence of copper nanoparticles and silver nanoparticles. To find the role of life time on the intensity of fluorescence, time resolved fluorescence measurements for the protein-sugar systems in the presence and absence of nanoparticles is measured. The proteinnanoparticles-sugar fluorescence interactions are analyzed by using Stern-Volmer plots and thermodynamic plots using fluorescence intensity quenching data. The trends in the extent of quenching action on protein fluorescence and also the binding interactions among protein sugar systems are quantified in the presence of copper nanoparticles and silver nanoparticles separately, in terms of Stern-Volmer constant values and binding constants values. β-Casein is found to interact strongly with the quenchers in the presence of copper nanoparticle and silver nanoparticle. Silver nanoparticle is read to be a better quenching mediator than copper nanoparticle for the fluorescence intensity in molecular interactions. Order of sugars quenching the protein fluorescence in presence of the nanoparticles is found.

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mentioning

confidence: 99%

Fluorescence Quenching of b-Casein by Silver Nanoparticles and Copper Nanoparticles in Presence of Sugars: A Quantitative Exploration

Vasumathi¹,

Santhanalakshmi²

2018

Asian J. Chem.

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“…Plasmonics [110] offers practical ways to miniaturize devices by providing enhanced absorption and scattering properties by optical coupling with free electrons. The use of plasmonic nanoparticles for diagnostic imaging and photothermal therapy have been extensively explored [111][112][113]. Several photonic devices incorporating plasmonic nanoparticles have been demonstrated.…”

Section: Plasmonic Devicesmentioning

confidence: 99%

Toward biomaterial-based implantable photonic devices

et al. 2017

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Optical technologies are essential for the rapid and efficient delivery of health care to patients. Efforts have begun to implement these technologies in miniature devices that are implantable in patients for continuous or chronic uses. In this review, we discuss guidelines for biomaterials suitable for use in vivo. Basic optical functions such as focusing, reflection, and diffraction have been realized with biopolymers. Biocompatible optical fibers can deliver sensing or therapeutic-inducing light into tissues and enable optical communications with implanted photonic devices. Wirelessly powered, light-emitting diodes (LEDs) and miniature lasers made of biocompatible materials may offer new approaches in optical sensing and therapy. Advances in biotechnologies, such as optogenetics, enable more sophisticated photonic devices with a high level of integration with neurological or physiological circuits. With further innovations and translational development, implantable photonic devices offer a pathway to improve health monitoring, diagnostics, and light-activated therapies.

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“…Different combinations of shape and size demonstrate differing properties that can be exploited for theranostic purposes, such as optical properties that allow use as a contrast agent, along with photothermal capabilities in the infrared and near-infrared range (35,36). The strongly enhanced radiative properties such as absorption, scattering, and a plasmonic field for surface-enhanced Raman of adjacent molecules make gold nanoparticles useful for molecular cancer diagnostics (37)(38)(39)(40)(41). Gold nanoparticle probes have been used to identify tuberculosis (42) as well as cancer biomarkers in the ex vivo setting (43).…”

Section: Goldmentioning

confidence: 99%

Prostate Cancer Imaging and Therapy: Potential Role of Nanoparticles

2016

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Over the last 2 decades, the use of nanoparticle imaging has been investigated extensively for both diagnosis and therapy of prostate cancer. This review discusses the various classes of nanoparticles currently in clinical use or at the advanced preclinical stage. In particular, we focus on the unique properties of nanoparticles, as a group, that make them suitable for imaging and therapy. The characteristics of each nanoparticle are detailed. Iron oxide nanoparticles, extensively used for MRI of prostate cancer, are discussed in depth.

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Optical Systems for in Vivo Molecular Imaging of Cancer

Cited by 195 publications

References 85 publications

Fluorescence Quenching of b-Casein by Silver Nanoparticles and Copper Nanoparticles in Presence of Sugars: A Quantitative Exploration

Fluorescence Quenching of b-Casein by Silver Nanoparticles and Copper Nanoparticles in Presence of Sugars: A Quantitative Exploration

Toward biomaterial-based implantable photonic devices

Prostate Cancer Imaging and Therapy: Potential Role of Nanoparticles

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