Optical sensing of biomolecules using microring resonators

Yalçın, Ayça; Popat, Ketul C.; Aldridge, J.; Desai, Tejal A.; Hryniewicz, J.V.; Chbouki, Nabil; Little, Brent E.; King, O.; Van, Vien; Chu, Sai T.; Gill, D.; Anthes-Washburn, M.; Ünlü, M. Selim; Goldberg, Bennett B.

doi:10.1109/jstqe.2005.863003

Cited by 350 publications

(180 citation statements)

References 19 publications

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“…3,4 The improvement over our previously published detection limit of 2.3 Â 10 À4 RIU is mainly due to the significant reduction of system noise down to 1.2 pm, achieved by using on chip temperature references, a smaller laser wavelength step, and, in particular, by fitting an analytical model to the whole spectrum obtained, thus effectively utilising all the information available. The slight increase in sensitivity, from 212 nm per RIU to 248 nm per RIU, also contributes, but to a much smaller extent.…”

Section: Discussionmentioning

confidence: 93%

“…One type of integrated optical sensor, that has recently been under intense investigation for on-chip label-free detection, is the planar waveguide ring resonator. [2][3][4][5] Due to its small footprint and ease of integration with other on-chip optical and fluidic functions, the ring resonator is a particularly interesting optical sensor for labs-on-chips.…”

Section: Integration Of Multiple Sensors For Parallel Operation and Omentioning

confidence: 99%

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A packaged optical slot-waveguide ring resonator sensor array for multiplex label-free assays in labs-on-chips

et al. 2010

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We present the design, fabrication, and characterisation of an array of optical slot-waveguide ring resonator sensors, integrated with microfluidic sample handling in a compact cartridge, for multiplexed real-time label-free biosensing. Multiplexing not only enables high throughput, but also provides reference channels for drift compensation and control experiments. Our use of alignment tolerant surface gratings to couple light into the optical chip enables quick replacement of cartridges in the read-out instrument. Furthermore, our novel use of a dual surface-energy adhesive film to bond a hard plastic shell directly to the PDMS microfluidic network allows for fast and leak-tight assembly of compact cartridges with tightly spaced fluidic interconnects. The high sensitivity of the slot-waveguide resonators, combined with on-chip referencing and physical modelling, yields a volume refractive index detection limit of 5 x 10(-6) refractive index units (RIUs) and a surface mass density detection limit of 0.9 pg mm(-2), to our knowledge the best reported values for integrated planar ring resonators.

QC 20100715

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Section: Discussionmentioning

confidence: 93%

Section: Integration Of Multiple Sensors For Parallel Operation and Omentioning

confidence: 99%

A packaged optical slot-waveguide ring resonator sensor array for multiplex label-free assays in labs-on-chips

et al. 2010

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QC 20100715

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“…WGM biosensing offers a particularly sensitive approach to quantify the mass loading of biomolecules on the resonator surface with ultimate sensitivity estimated on the single molecule level [19,20]. WGM biosensors derive their unprecedented sensitivity from the use of high quality-factor (Q-factor) optical resonances to monitor wavelength shift signals upon binding of biomolecules or nanobeads to the resonator surface [20][21][22][23][24][25]. The simplest WGM biosensor is a glass microsphere (typically 50-100 mm in diameter) where the resonant light remains confined by total-internal reflection.…”

Section: Biophotonicsmentioning

confidence: 99%

Ultrasensitive detection of a protein by optical trapping in a photonic‐plasmonic microcavity

Santiago-Cordoba

Çetinkaya

Boriskina

et al. 2012

Journal of Biophotonics

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Microcavity and whispering gallery mode (WGM) biosensors derive their sensitivity from monitoring frequency shifts induced by protein binding at sites of highly confined field intensities, where field strengths can be further amplified by excitation of plasmon resonances in nanoparticle layers. Here, we propose a mechanism based on optical trapping of a protein at the site of plasmonic field enhancements for achieving ultra sensitive detection in only microliter-scale sample volumes, and in real-time. We demonstrate femto-Molar sensitivity corresponding to a few 1000 s of macromolecules. Simulations based on Mie theory agree well with the optical trapping concept at plasmonic hotspots locations. ((c) 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

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“…In order to overcome this limitation, photonic sensors based on micro-resonators have been recently proposed. They are much more compact in size (e.g., three orders of magnitude less) [6,7] and exhibit a sensitivity which is comparable to the one of Mach-Zehnder-type sensors [8].…”

Section: Introductionmentioning

confidence: 99%

Metamaterial-Based Sensor Design Working in Infrared Frequency Range

Spada¹,

Bilotti²,

Vegni³

2011

PIER B

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Abstract-In this paper, we propose the design of high sensitivity and selectivity metamaterial-based biosensors operating in the THz regime. The proposed sensors consist of planar array of resonant metallic structures, whose frequency response is modified through the variation of the surrounding dielectric environment. We consider different resonator geometries, such as the squared, circular, asymmetrical, and omega ones, and the analysis of the biosensors is conducted through proper equivalent quasi-static analytical circuit models. The metallic particles are assumed deposited on a glass substrate through proper titanium adhesion layers. Exploiting the proposed analytical model, which is verified through the comparison to full-wave numerical simulations, we study the biosensor resonance frequencies as a function of the geometric parameters of the individual inclusions. Finally, we optimize the structure in order to obtain high sensitivity and selectivity performances. The numerical results show that the proposed structures can be successfully applied as biosensors working in the THz region.

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Optical sensing of biomolecules using microring resonators

Abstract: Abstract-A biosensor application of vertically coupled glass microring resonators with Q ∼ 12 000 is introduced. Using balanced photodetection, very high signal to noise ratios, and thus high sensitivity to refractive index changes (limit of detection of 1.8 × 10

Cited by 350 publications

References 19 publications

A packaged optical slot-waveguide ring resonator sensor array for multiplex label-free assays in labs-on-chips

A packaged optical slot-waveguide ring resonator sensor array for multiplex label-free assays in labs-on-chips

Ultrasensitive detection of a protein by optical trapping in a photonic‐plasmonic microcavity

Metamaterial-Based Sensor Design Working in Infrared Frequency Range

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