Optical sensing and control of T cell signaling pathways
Hae Nim Lee,
Seung Eun Lee,
Kyung-Soo Inn
et al.
Abstract:T cells regulate adaptive immune responses through complex signaling pathways mediated by T cell receptor (TCR). The functional domains of the TCR are combined with specific antibodies for the development of chimeric antigen receptor (CAR) T cell therapy. In this review, we first overview current understanding on the T cell signaling pathways as well as traditional methods that have been widely used for the T cell study. These methods, however, are still limited to investigating dynamic molecular events with s… Show more
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