Optical Sectioning of the Cornea with a New Confocal In Vivo Slit-scanning Videomicroscope

Wiegand, Wolfgang; Thaer, A.; Kroll, P.; Geyer, Otto-C.; Garcı́a, Alberto

doi:10.1016/s0161-6420(95)30981-5

Cited by 71 publications

(45 citation statements)

References 10 publications

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“…[33][34][35] As a result of the optical principles involved in specular microscopy, there are limitations to the use of this instrument. The cornea should be transparent and the endothelial surface should be regular and smooth in order to obtain specular reflection.…”

Section: Discussionmentioning

confidence: 99%

Coupling of HRT II and AS-OCT to evaluate corneal endothelial cell loss and in vivo visualization of the Ahmed glaucoma valve implant

Mendrinos

Dosso

Sommerhalder

et al. 2008

Eye

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Section: Discussionmentioning

confidence: 99%

Coupling of HRT II and AS-OCT to evaluate corneal endothelial cell loss and in vivo visualization of the Ahmed glaucoma valve implant

Mendrinos

Dosso

Sommerhalder

et al. 2008

Eye

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“…Superficial epithelial cells become highly reflective before desquamation. 15 To assess epithelial damage, percentage of highly reflective superficial epithelial cells was calculated by dividing highly reflective cells per frame by total number of superficial epithelial cells per frame and multiplying by 100. For epithelial cell size, operators defined the borders of superficial epithelial cells manually with the Confoscan Software NAVIS, calculating the epithelial cell area after manual delineation of cell borders.…”

Section: Image Analysismentioning

confidence: 99%

Cellular and subbasal nerve alterations in early stage Fuchs’ endothelial corneal dystrophy: an in vivo confocal microscopy study

Schrems-Hoesl

Schrems

Cruzat

et al. 2012

Eye

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Purpose To analyze the morphology and density of corneal epithelial cells, keratocytes, and subbasal nerves, in patients with early stage Fuchs' endothelial corneal dystrophy (FECD) by in vivo confocal microscopy (IVCM). Methods IVCM (Confoscan 4, Nidek, Inc.) of the central cornea was performed in 30 corneas of 30 patients with early stage FECD and 13 corneas of 13 normal controls. Images were analyzed for morphology and density of the superficial and basal epithelial cells, keratocyte density, endothelial cell density (ECD), as well as subbasal corneal nerve parameters. Central corneal thickness (CCT) was measured in all patients and normals by ultrasound pachymetry. Results The ECD was significantly lower ( À 45.5%, Po0.001) in FECD patients as compared with controls. Total number of nerves and main nerve trunks were significantly reduced ( À 46.3%, Po0.001; À 39.7%, Po0.001) in patients with FECD. Posterior keratocyte density was significantly higher in FECD patients (Po0.001). Significant inverse correlations were found between CCT and total number of nerves (r ¼ À 0.69, Po0.001), CCT and main nerve trunks ( À 0.47, P ¼ 0.016), as well as CCT and total nerve length (r ¼ À 0.62, P ¼ 0.006). Significant correlation was found between ECD and total number of nerves (r ¼ 0.44, P ¼ 0.012) as well as between ECD and main nerve trunks (r ¼ 0.65, Po0.001). Conclusions IVCM demonstrates alterations in corneal innervation in patients with early stage FECD, suggesting a potential role of corneal nerves in the pathogenesis of FECD. Additional studies are required to investigate whether subbasal nerve alterations are caused by nonspecific corneal edema, from FECDinduced decrease in ECD, or potentially leading to loss of endothelial cells.

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“…The principle of confocal microscopy has been described in detail elsewhere 9,10 and there were no adverse effects following assessment.…”

Section: In Vivo Confocal Microscopymentioning

confidence: 99%

Quantitative analysis of corneal microstructure in keratoconus utilising in vivo confocal microscopy

Weed

MacEwen

Cox

et al. 2006

Eye

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Optical Sectioning of the Cornea with a New Confocal In Vivo Slit-scanning Videomicroscope

Cited by 71 publications

References 10 publications

Coupling of HRT II and AS-OCT to evaluate corneal endothelial cell loss and in vivo visualization of the Ahmed glaucoma valve implant

Coupling of HRT II and AS-OCT to evaluate corneal endothelial cell loss and in vivo visualization of the Ahmed glaucoma valve implant

Cellular and subbasal nerve alterations in early stage Fuchs’ endothelial corneal dystrophy: an in vivo confocal microscopy study

Quantitative analysis of corneal microstructure in keratoconus utilising in vivo confocal microscopy

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