Optical sectioning for microfluidics: secondary flow and mixing in a meandering microchannel

Ahn, Yeh‐Chan; Jung, Woonggyu; Chen, Zhongping

doi:10.1039/b713626a

Cited by 59 publications

(60 citation statements)

References 34 publications

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“…Reference cross sectional planes (based on the geometry of the channel) to represent such flows can yield inaccurate results since, in general, it cannot be guaranteed that the streamlines of a flow, for which inertial effects can be neglected, are indeed perpendicular to the reference plane at any point. This is particularly true for the case of channels with complex geometries such as serpentines or mixers where new techniques have to be applied in order to visualize the complicated flow patterns that emerge [41,42]. Figure 4 depicts the 3d fluid domain employed during the FSI simulation process.…”

Section: Model and Methodsmentioning

confidence: 99%

Two-Way Coupling FSI Approach to Inertial Focusing Dynamics Under Dean Flow Patterns in Asymmetric Serpentines

Pedrol¹,

Díaz²,

Aguiló³

2018

Preprint

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The dynamics of a spherical particle in an asymmetric serpentine are studied by finite element method (FEM) simulations in a physically unconstrained system. The two-way coupled time dependent solutions illustrate the path of the particle along a curve where a secondary flow (Dean flow) has developed. The simulated conditions were adjusted to match those of an experiment for which particles were focused under inertial focusing conditions in a microfluidic device. The obtained rotational modes allowed to infer the influence of the local flow around the particle. We propose a new approach to find the decoupled secondary flow contribution employing a quasi-Stokes flow.

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Section: Model and Methodsmentioning

confidence: 99%

Two-Way Coupling FSI Approach to Inertial Focusing Dynamics Under Dean Flow Patterns in Asymmetric Serpentines

Pedrol¹,

Díaz²,

Aguiló³

2018

Preprint

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“…A mathematical description for the principle of the spectraldomain OCT was previously described in detail. 30 Here, we summarize how it works. Reflected lights from the immobilized mirror and each scattering particle in a sample make a signal in spectral domain that is detected by the spectrometer.…”

Section: Spectral-domain Optical Coherence Tomographymentioning

confidence: 99%

Multimodality approach to optical early detection and mapping of oral neoplasia

et al. 2011

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Abstract. Early detection of cancer remains the best way to ensure patient survival and quality of life. Squamous cell carcinoma is usually preceded by dysplasia presenting as white, red, or mixed red and white epithelial lesions on the oral mucosa (leukoplakia, erythroplakia). Dysplastic lesions in the form of erythroplakia can carry a risk for malignant conversion of 90%. A noninvasive diagnostic modality would enable monitoring of these lesions at regular intervals and detection of treatment needs at a very early, relatively harmless stage. The specific aim of this work was to test a multimodality approach [three-dimensional optical coherence tomography (OCT) and polarimetry] to noninvasive diagnosis of oral premalignancy and malignancy using the hamster cheek pouch model (nine hamsters). The results were compared to tissue histopathology. During carcinogenesis, epithelial down grow, eventual loss of basement membrane integrity, and subepithelial invasion were clearly visible with OCT. Polarimetry techniques identified a four to five times increased retardance in sites with squamous cell carcinoma, and two to three times greater retardance in dysplastic sites than in normal tissues. These techniques were particularly useful for mapping areas of field cancerization with multiple lesions, as well as lesion margins.C 2011 Society of Photo-Optical Instrumentation Engineers (SPIE).

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“…3D-image reconstruction is a promising means to interpret a flow field exactly, so avoiding poor estimates. These techniques include magnetic-resonance imaging ͑MRI͒, 25 nuclear-magneticresonance ͑NMR͒ microscopy, [26][27][28] circular-dichroism spectra with synchrotron radiation ͑CDSR͒, 29 and optical-coherence tomography ͑OCT͒, 30,31 and the use of a deconvolution microscope, 32 laser-sheet illumination microscope, 33 confocal microscope, 34 two-photon absorption fluorescence microscope, 35 and a coherent anti-Stokes Raman scattering ͑CARS͒ microscope. 36 They have received much attention in the biological and medical fields, and their application to microfluidics is thriving.…”

Section: Introductionmentioning

confidence: 99%

Characterization of microfluidic mixing and reaction in microchannels via analysis of cross-sectional patterns

et al. 2011

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For the diagnosis of biochemical reactions, the investigation of microflow behavior, and the confirmation of simulation results in microfluidics, experimentally quantitative measurements are indispensable. To characterize the mixing and reaction of fluids in microchannel devices, we propose a mixing quality index ͑M qi ͒ to quantify the cross-sectional patterns ͑also called mixing patterns͒ of fluids, captured with a confocal-fluorescence microscope ͑CFM͒. The operating parameters of the CFM for quantification were carefully tested. We analyzed mixing patterns, flow advection, and mass exchange of fluids in the devices with overlapping channels of two kinds. The mixing length of the two devices derived from the analysis of M qi is demonstrated to be more precise than that estimated with a commonly applied method of blending dye liquors. By means of fluorescence resonance-energy transfer ͑FRET͒, we monitored the hybridization of two complementary oligonucleotides ͑a FRET pair͒ in the devices. The captured patterns reveal that hybridization is a progressive process along the downstream channel. The FRET reaction and the hybridization period were characterized through quantification of the reaction patterns. This analytical approach is a promising diagnostic tool that is applicable to the real-time analysis of biochemical and chemical reactions such as polymerase chain reaction ͑PCR͒, catalytic, or synthetic processes in microfluidic devices.

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Optical sectioning for microfluidics: secondary flow and mixing in a meandering microchannel

Cited by 59 publications

References 34 publications

Two-Way Coupling FSI Approach to Inertial Focusing Dynamics Under Dean Flow Patterns in Asymmetric Serpentines

Two-Way Coupling FSI Approach to Inertial Focusing Dynamics Under Dean Flow Patterns in Asymmetric Serpentines

Multimodality approach to optical early detection and mapping of oral neoplasia

Characterization of microfluidic mixing and reaction in microchannels via analysis of cross-sectional patterns

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