Optical-resolution functional gastrointestinal photoacoustic endoscopy based on optical heterodyne detection of ultrasound

Liang, Yong; Fu, Wubing; Li, Qiang; Chen, Xiaolong; Sun, Huojiao; Wang, Lidai; Jin, Long; Guan, Bai‐Ou

doi:10.1038/s41467-022-35259-5

Cited by 26 publications

(20 citation statements)

References 48 publications

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“…The energy transduction coefficient of the two US sensors was also estimated by considering their thin-film characteristics. The developed needle US sensor exhibited a higher value, suggesting a more efficient energy conversion and superior performance, as shown in Table 1 2 , 10 …”

Section: Methodsmentioning

confidence: 98%

“…The developed needle US sensor exhibited a higher value, suggesting a more efficient energy conversion and superior performance, as shown in Table 1. 2,10 We performed hydrophone directivity measurements to evaluate the effects of the incident angle of US waves originating from different scan points. The experimental results indicate that the detected amplitudes can be maintained at >90% levels from the peak values for incident angles in the AE5 deg range [Fig.…”

Section: Methodsmentioning

confidence: 99%

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Highly sensitive miniature needle PVDF-TrFE ultrasound sensor for optoacoustic microscopy

Liu

Kurnikov

et al. 2023

Adv. Photon. Nexus

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.A wideband sensitive needle ultrasound sensor based on a polarized PVDF-TrFE copolymer piezoelectric film has been developed, which is capable of providing a noise equivalent pressure of 14 Pa and a uniform frequency response ranging from 1 to 25 MHz. Its high sensitivity (1.6 μV / Pa) and compact size were achieved by capitalizing on the large electromechanical coupling coefficient of PVDF-TrFE and minimizing parasitic capacitance in a two-stage amplifier structure. The detection sensitivity of the newly designed sensor outperformed commercially available hydrophones with an equivalent sensing element area by a factor of 9. The sensor has been successfully integrated into a light scanning optoacoustic microscopy (OAM) system with a limited working space. Submicrometer resolution images were subsequently attained from living mice without employing signal averaging. The miniature sensor design can readily be integrated into various OAM systems and further facilitate multimodal imaging system implementations.

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Section: Methodsmentioning

confidence: 98%

Section: Methodsmentioning

confidence: 99%

Highly sensitive miniature needle PVDF-TrFE ultrasound sensor for optoacoustic microscopy

Liu

Kurnikov

et al. 2023

Adv. Photon. Nexus

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“… 18 PA endoscopy (PAE) is essentially a variant of PAM, grounded in the same principles. However, it typically incorporates a compact probe and captures PA images through rotational scanning 19 or MEMS mirror scanning. 20 …”

Section: Introductionmentioning

confidence: 99%

“…In recent years, several different optical ultrasound sensors have been explored in PA imaging. 19 , 25 , 26 Their main advantages include wide bandwidth, low electromagnetic interference, and high sensitivity per unit area. 27 – 32 These optical ultrasound sensors have undergone significant development, especially fiber laser sensor that has not been elaborated upon in detail in existing reviews.…”

Section: Introductionmentioning

confidence: 99%

Optical ultrasound sensors for photoacoustic imaging: a review

Zhu,

Cao,

et al. 2024

J. Biomed. Opt.

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. Significance Photoacoustic (PA) imaging is an emerging biomedical imaging modality that can map optical absorption contrast in biological tissues by detecting ultrasound signal. Piezoelectric transducers are commonly used in PA imaging to detect the ultrasound signals. However, piezoelectric transducers suffer from low sensitivity when the dimensions are reduced and are easily influenced by electromagnetic interference. To avoid these limitations, various optical ultrasound sensors have been developed and shown their great potential in PA imaging. Aim Our study aims to summarize recent progress in optical ultrasound sensor technologies and their applications in PA imaging. Approach The commonly used optical ultrasound sensing techniques and their applications in PA systems are reviewed. The technical advances of different optical ultrasound sensors are summarized. Results Optical ultrasound sensors can provide wide bandwidth and improved sensitivity with miniatured size, which enables their applications in PA imaging. Conclusions The optical ultrasound sensors are promising transducers in PA imaging to provide higher-resolution images and can be used in new applications with their unique advantages.

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“…Guan Baiou et al reported a photoacoustic imaging application of fiber laser bent into different diameters to achieve ultrasonic response with different spatial resolution [ 15 ]. In 2022, Guan’s team developed a miniaturized photoacoustic endoscope system with a noise equivalent pressure density (NEPD) below 1.5 mPa/Hz 1/2 and a measurement range from 5 to 25 MHz [ 16 ]. As a highly sensitive candidate, the DBR fiber laser is also promising for marine applications such as pressure, tsunami, and earth dynamics [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Measurement of the Acoustic Relaxation Absorption Spectrum of CO2 Using a Distributed Bragg Reflector Fiber Laser

Shen

Yuan

et al. 2023

Sensors

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Reconstruction of the acoustic relaxation absorption curve is a powerful approach to ultrasonic gas sensing, but it requires knowledge of a series of ultrasonic absorptions at various frequencies around the effective relaxation frequency. An ultrasonic transducer is the most widely deployed sensor for ultrasonic wave propagation measurement and works only at a fixed frequency or in a specific environment like water, so a large number of ultrasonic transducers operating at various frequencies are required to recover an acoustic absorption curve with a relative large bandwidth, which cannot suit large-scale practical applications. This paper proposes a wideband ultrasonic sensor using a distributed Bragg reflector (DBR) fiber laser for gas concentration detection through acoustic relaxation absorption curve reconstruction. With a relative wide and flat frequency response, the DBR fiber laser sensor measures and restores a full acoustic relaxation absorption spectrum of CO2 using a decompression gas chamber between 0.1 and 1 atm to accommodate the main molecular relaxation processes, and interrogates with a non-equilibrium Mach-Zehnder interferometer (NE-MZI) to gain a sound pressure sensitivity of −45.4 dB. The measurement error of the acoustic relaxation absorption spectrum is less than 1.32%.

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Optical-resolution functional gastrointestinal photoacoustic endoscopy based on optical heterodyne detection of ultrasound

Cited by 26 publications

References 48 publications

Highly sensitive miniature needle PVDF-TrFE ultrasound sensor for optoacoustic microscopy

Highly sensitive miniature needle PVDF-TrFE ultrasound sensor for optoacoustic microscopy

Optical ultrasound sensors for photoacoustic imaging: a review

Measurement of the Acoustic Relaxation Absorption Spectrum of CO2 Using a Distributed Bragg Reflector Fiber Laser

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