Optical readout of the intracellular environment using nanoparticle transducers

Dowd, Annette; Pissuwan, Dakrong; Cortie, Michael B.

doi:10.1016/j.tibtech.2014.09.004

Cited by 12 publications

(7 citation statements)

References 75 publications

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“…3)The dependence of the interaction on the wavelength of the exciting radiation offers a means to achieve various kinds of spectral selectivity in a material or nanostructures 4)Perturbation of the resonance, as for example by a change in the refractive index or redox potential of the surrounding medium or resonator itself, offers a means to achieve optical transduction of a chemical or physical signal 5)The enhanced absorption that can accompany a plasmon resonance can be coupled with its spectral selectivity to provide a means to achieve localized heating, with potential uses in medicine .…”

Section: Introductionmentioning

confidence: 99%

The Quest for Zero Loss: Unconventional Materials for Plasmonics

2019

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There has been an ongoing quest to optimize the materials used to build plasmonic devices: first the elements were investigated, then alloys and intermetallic compounds, later semiconductors were considered, and, most recently, there has been interest in using more exotic materials such as topological insulators and conducting oxides. The quality of the plasmon resonances in these materials is closely correlated with their structure and properties. In general gold and silver are the most commonly specified materials for these applications but they do have weaknesses. Here, it is shown how, in specific circumstances, the selection of certain other materials might be more useful. Candidate alternatives include TixN, VO2, Al, Cu, Al‐doped ZnO, and Cu–Al alloys. The relative merits of these choices and the many pitfalls and subtle problems that arise are discussed, and a frank perspective on the field is provided.

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Section: Introductionmentioning

confidence: 99%

The Quest for Zero Loss: Unconventional Materials for Plasmonics

2019

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“…As the most critical issue for this application, the stability of the InGaN/GaN NW heterostructure arrays was assessed in comparison to pH‐sensitive probes that are currently in use for biochemical imaging applications . In addition to absorption or fluorescence‐based optical probes that do either change the color or show a difference in their fluorescence properties, nanoparticles such as semiconductor quantum dots are frequently used as optical transducers and have recently been improved with respect to their stability against photobleaching …”

Section: Resultsmentioning

confidence: 99%

Dynamic Extracellular Imaging of Biochemical Cell Activity Using InGaN/GaN Nanowire Arrays as Nanophotonic Probes

Hölzel

Zyuzin

Wallys

et al. 2018

Adv Funct Materials

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The application of InGaN/GaN nanowire heterostructure arrays as photonic probes for dynamic imaging of biochemical and cellular processes in an incident light fluorescence microscope is demonstrated. The photoluminescence intensity of InGaN/GaN nanowires sensitively depends on the pH value of the surrounding solution, making them suitable probes for the optical detection of biochemical processes accompanied by local pH variations. Grown on a conductive substrate, the nanowire arrays can be operated in a well-defined electrochemical working point with high sensitivity and stability. The achievable pH and bias resolution as well as signal-to-noise ratio are assessed as a function of the working point and for different integration times. A bias resolution of 1 mV and a pH resolution of 0.03 are achieved at a time resolution below 25 ms. The application for dynamic imaging of the activity of isolated intestinal crypts from Wistar rats is demonstrated. Here, the pH change in the vicinity of the crypt is quantified and attributed to the activity of the sodium-proton exchanger (NHE). Imaging of the effect of amiloride and NH 4 Cl on its activity is demonstrated with a spatial resolution of <0.63 µm and reveals that NH 4 Cl-induced NHE activation preferentially occurs in the upper part of the crypt.

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“…One of the present authors has, for example, used colloids of Au nanorods to detect very small amounts of biological molecules on the surfaces of macrophage cells (Pissuwan & Hattori, 2016), or to detect different molecules that are actually inside cells (Pissuwan, Hobro, Pavillon, & Smith, 2014). The latter mode of operation provides one of the very few techniques (Dowd, Pissuwan, & Cortie, 2014) available for remote optical analysis of the intracellular chemical environment (Qian et al, 2008). Not surprisingly, SERS has also received attention as a tool for identifying pathogens, including in food (Zhao, Li, & Xu, 2018).…”

Section: Sersmentioning

confidence: 99%

Single and multiple detections of foodborne pathogens by gold nanoparticle assays

Pissuwan

Gazzana

Mongkolsuk

et al. 2019

WIREs Nanomed Nanobiotechnol

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A late detection of pathogenic microorganisms in food and drinking water has a high potential to cause adverse health impacts in those who have ingested the pathogens. For this reason there is intense interest in developing precise, rapid and sensitive assays that can detect multiple foodborne pathogens. Such assays would be valuable components in the campaign to minimize foodborne illness. Here, we discuss the emerging types of assays based on gold nanoparticles (GNPs) for rapidly diagnosing single or multiple foodborne pathogen infections. Colorimetric and lateral flow assays based on GNPs may be read by the human eye. Refractometric sensors based on a shift in the position of a plasmon resonance absorption peak can be read by the new generation of inexpensive optical spectrometers. Surface‐enhanced Raman spectroscopy and the quartz microbalance require slightly more sophisticated equipment but can be very sensitive. A wide range of electrochemical techniques are also under development. Given the range of options provided by GNPs, we confidently expect that some, or all, of these technologies will eventually enter routine use for detecting pathogens in food. This article is categorized under: Diagnostic Tools > Biosensing

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Optical readout of the intracellular environment using nanoparticle transducers

Cited by 12 publications

References 75 publications

The Quest for Zero Loss: Unconventional Materials for Plasmonics

The Quest for Zero Loss: Unconventional Materials for Plasmonics

Dynamic Extracellular Imaging of Biochemical Cell Activity Using InGaN/GaN Nanowire Arrays as Nanophotonic Probes

Single and multiple detections of foodborne pathogens by gold nanoparticle assays

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