How to implement a computation task efficiently is the central problem in quantum computation science. For a quantum circuit, the multi-control unitary operations are the very important components. We present an extremely efficient approach to implement multiple multi-control unitary operations directly without any decompositions to CNOT gates and single-photon gates. The necessary two-photon operations could be reduced from O(n 3 ) with the traditional decomposition approach to O(n) with the present approach, which will greatly relax the requirement resources and make this approach much feasible for large scale quantum computation. Moreover, the potential application to the (n-k)-uniform hypergraph state generation is proposed.multi-control unitary operation, cross phase modulation, c-path gate, merging gate, hypergraph state PACS number(s): 03.67. Lx, 42.50.Dv Citation: