Optical properties of solute molecules: Environmental effects, challenges, and their practical implications

Homocianu, Mihaela

doi:10.1016/j.microc.2020.105797

Cited by 6 publications

(2 citation statements)

References 165 publications

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“…To further investigate the mechanisms by which this compound exerts its photodependent biological activity, we studied the spectral dependence of OptoNAM-3 photoisomerization in solution (referred to “free OptoNAM-3” below) and in a cellular context (referred to “bound OptoNAM-3” below). Azobenzenes indeed exhibit strong electronic absorption of their conjugated pi system and their absorption spectra can be altered when they aggregate, are complexed, or simply dwell in a different solvent (64, 65). We would thus expect the photochemical properties of bound OptoNAM-3, which is confined in its binding site and exerts multiple non-bonding interactions with it, to differ from the ones of free OptoNAM-3.…”

Section: Resultsmentioning

confidence: 99%

Reversible inhibition of GluN2B-containing NMDA receptors with anin situred-shifted, photoswitchable antagonist

Geoffroy,

Berraud-Pache,

Chéron

et al. 2023

Preprint

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NMDA receptors (NMDARs) are glutamate-gated ion channels playing a central role in synaptic transmission and plasticity. Dysregulation of NMDARs is linked to various neuropsychiatric disorders, emphasizing the need to understand the functional roles of individual NMDAR subtypes in the brain. GluN2B-containing NMDARs (GluN2B-NMDARs) are particularly important due to both pro-cognitive and pro-excitotoxic roles, although these functions remain under debate. Traditional pharmacological and genetic approaches have important shortcomings in terms of specificity and spatio-temporal resolution, limiting their use in native tissues. We therefore turned to optopharmacology, a technique based on the use of photosensitive ligands, whose activity can be reversibly tuned via illumination with different wavelengths. We developed OptoNAM-3, an azobenzene-based, photoswitchable negative allosteric modulator selective for GluN2B-NMDARs. OptoNAM-3 is a potent inhibitor of GluN2B-NMDARs in its trans configuration and inactive in its cis configuration. When bound to GluN2B-NMDARs, OptoNAM-3 displays remarkable red-shifting of its photoswitching properties that we attributed to geometric constraints imposed by the binding site onto the ligand azobenzene moiety. OptoNAM-3 allowed fast and reversible photomodulation of GluN2B-NMDAR activity in vitro using either UV/green or blue/green light illumination cycles. OptoNAM-3 furthermore acted as a reversible, red-shifted in vivo photomodulator of Xenopus tadpole locomotion. By enabling fast and reversible photocontrol of endogenous GluN2B-NMDARs with in vivo compatible photochemical properties, OptoNAM-3 should advance our understanding of the role of this class of NMDARs in brain function and dysfunction.

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Section: Resultsmentioning

confidence: 99%

Reversible inhibition of GluN2B-containing NMDA receptors with anin situred-shifted, photoswitchable antagonist

Geoffroy,

Berraud-Pache,

Chéron

et al. 2023

Preprint

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“…Photochromic materials have gained great interest recently due to their unique photoresponsive behavior and promising applications as smart materials [ 1 , 2 ].…”

Section: Introductionmentioning

confidence: 99%

Solvatochromism, Acidochromism and Photochromism of the 2,6-Bis(4-hydroxybenzylidene) Cyclohexanone Derivative

Homocianu¹,

Serbezeanu²,

Vlad‐Bubulac³

2023

IJMS

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In this paper, we studied the photophysical behavior of 2,6-bis(4-hydroxybenzylidene) cyclohexanone (BZCH) under the influence of various stimuli. The photophysical properties were correlated with different solvent parameters, such as the Kamlet–Abraham–Taft (KAT), Catalán, and Laurence solvent scales, suggesting that the behavior of BZCH is influenced by both nonspecific and specific solvent-solute interactions. The Catalán solvent dipolarity/polarizability parameters were found to have a significant role in the solvatochromic behavior, which is also confirmed by the KAT and Laurence models. The acidochromism and photochromism properties of this sample in dimethylsulfoxide and chloroform solutions were also investigated. The compound showed reversible acidochromism after the addition of dilute NaOH/HCl solutions, accompanied by a change in color and the appearance of a new absorption band (514 nm). The photochemical behavior was also examined by irradiating BZCH solutions with both 254 and 365 nm light.

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Thermosolvatochromic Behavior of Quinolinium and Pyridinium 4-Hydroxystyryl Dyes in Solutions

et al. 2023

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Optical properties of solute molecules: Environmental effects, challenges, and their practical implications

Cited by 6 publications

References 165 publications

Reversible inhibition of GluN2B-containing NMDA receptors with anin situred-shifted, photoswitchable antagonist

Reversible inhibition of GluN2B-containing NMDA receptors with anin situred-shifted, photoswitchable antagonist

Solvatochromism, Acidochromism and Photochromism of the 2,6-Bis(4-hydroxybenzylidene) Cyclohexanone Derivative

Thermosolvatochromic Behavior of Quinolinium and Pyridinium 4-Hydroxystyryl Dyes in Solutions

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