Optical properties of platelets and blood plasma and their influence on the optical behavior of whole blood in the visible to near infrared wavelength range

Meinke, Martina C.; Müller, G.; Helfmann, Jürgen; Friebel, M.F.

doi:10.1117/1.2435177

Cited by 154 publications

(103 citation statements)

References 21 publications

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“…This effect, which shows similarities to a catacaustic being produced by the envelope of light rays reflected or refracted by spherical surfaces, is also observable in images of human retinal blood vessels in vivo published by others. 1,2 As the scattering of blood is mainly caused by its cellular components 3 with a majority of red blood cells (RBCs), probably their intravascular orientation is responsible for the observed intensity pattern. Already in 1922, Jeffrey published a theoretical paper about the motion of ellipsoid particles immersed in a viscous liquid.…”

Section: Introductionmentioning

confidence: 99%

Shear flow-induced optical inhomogeneity of blood assessed in vivo and in vitro by spectral domain optical coherence tomography in the 1.3 μm wavelength range

et al. 2011

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Abstract. The optical inhomogeneity of flowing blood, which appears as a waisted double fan-shaped intensity pattern inside vessels in cross-sectional optical coherence tomography (OCT) images, was investigated for the first time. High resolution spectral domain OCT in the 1.3 μm wavelength region is used to assess this inhomogeneous intravascular backscattering of light in an in vivo mouse model and flow phantom measurements. Based on a predicted alignment of the red blood cells toward laminar shear flow, an angular modulation of the corresponding backscattering cross-section inside the vessels is assumed. In combination with the signal attenuation in depth by absorption and scattering, a simple model of the intravascular intensity modulation is derived. The suitability of the model is successfully demonstrated in the in vivo experiments and confirmed by the in vitro measurements. The observed effect appears in flowing blood only and shows a strong dependency on the shear rate. In conclusion, the shear-induced red blood cell alignment in conjunction with the vessel geometry is responsible for the observed intensity distribution. This inherent effect of blood imaging has to be considered in attenuation measurements performed with OCT. Furthermore, the analysis of the intravascular intensity pattern might be useful to evaluate flow characteristics. C 2011 Society of Photo-Optical Instrumentation Engineers (SPIE).

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Section: Introductionmentioning

confidence: 99%

Shear flow-induced optical inhomogeneity of blood assessed in vivo and in vitro by spectral domain optical coherence tomography in the 1.3 μm wavelength range

et al. 2011

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“…The optical properties of the tissues [5][6][7] for 830 nm incident light are ͑ a = 0.03 mm −1 , s = 0.06 mm −1 ͒ for plasma, ͑0.45, 30.0͒ for RBCs, and ͑0.5, 1.2͒ for static tissue. Despite the very low volume fraction [8][9][10] of RBCs ͑i.e., 0.005-0.003͒, the optical constants of plasma, red blood cells, and other skin constituent materials are such that the net propagation of light is mostly determined by the RBCs.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous, noninvasive observation of elastic scattering, fluorescence and inelastic scattering as a monitor of blood flow and hematocrit in human fingertip capillary beds

et al. 2009

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Abstract.We report simultaneous observation of elastic scattering, fluorescence, and inelastic scattering from in vivo near-infrared probing of human skin. Careful control of the mechanical force needed to obtain reliable registration of in vivo tissue with an appropriate optical system allows reproducible observation of blood flow in capillary beds of human volar side fingertips. The time dependence of the elastically scattered light is highly correlated with that of the combined fluorescence and Raman scattered light. We interpret this in terms of turbidity ͑the impeding effect of red blood cells on optical propagation to and from the scattering centers͒ and the changes in the volume percentages of the tissues in the irradiated volume with normal homeostatic processes. By fitting to a model, these measurements may be used to determine volume fractions of plasma and RBCs.

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“…Indeed, they can be confounded by the presence of additional tissue chromophores such as beta-carotene, and by variations in the wavelength dependence of optical scattering. To estimate the concentrations of oxy-and deoxy-hemoglobin in tissue, it may be important to account for multiple factors such as the aggregation and flow of erythrocytes, and the concentrations of plasma constituents such as bilirubin and platelets [22].…”

Section: Discussionmentioning

confidence: 99%

Epidural catheter with integrated light guides for spectroscopic tissue characterization

Soto-Astorga

West

Putnis

et al. 2013

Biomed. Opt. Express

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Epidural catheters are used to deliver anesthetics and opioids for managing pain in many clinical scenarios. Currently, epidural catheter insertion is performed without information about the tissues that are directly ahead of the catheter. As a result, the catheter can be incorrectly positioned within a blood vessel, which can cause toxicity. Recent studies have shown that optical reflectance spectroscopy could be beneficial for guiding needles that are used to insert catheters. In this study, we investigate the whether this technique could benefit the placement of catheters within the epidural space. We present a novel optical epidural catheter with integrated polymer light guides that allows for optical spectra to be acquired from tissues at the distal tip. To obtain an initial indication of the information that could be obtained, reflectance values and photon penetration depth were estimated using Monte Carlo simulations, and optical reflectance spectra were acquired during a laminectomy of a swine ex vivo. Large differences between the spectra acquired from epidural adipose tissue and from venous blood were observed. The optical catheter has the potential to provide realtime detection of intravascular catheter placement that could reduce the risk of complications.

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Optical properties of platelets and blood plasma and their influence on the optical behavior of whole blood in the visible to near infrared wavelength range

Cited by 154 publications

References 21 publications

Shear flow-induced optical inhomogeneity of blood assessed in vivo and in vitro by spectral domain optical coherence tomography in the 1.3 μm wavelength range

Shear flow-induced optical inhomogeneity of blood assessed in vivo and in vitro by spectral domain optical coherence tomography in the 1.3 μm wavelength range

Simultaneous, noninvasive observation of elastic scattering, fluorescence and inelastic scattering as a monitor of blood flow and hematocrit in human fingertip capillary beds

Epidural catheter with integrated light guides for spectroscopic tissue characterization

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