The James Webb Space Telescope (JWST) is the scientific successor to the Hubble Space Telescope. It is a cryogenic infrared space observatory with a 25 m 2 aperture (6 m class) telescope that will achieve diffraction limited angular resolution at a wavelength of 2 um. The science instrument payload includes four passively cooled near-infrared instruments providing broad-and narrow-band imagery, coronography, as well as multi-object and integral-field spectroscopy over the 0.6 < λ < 5.0 um spectrum. An actively cooled mid-infrared instrument provides broad-band imagery, coronography, and integral-field spectroscopy over the 5.0 < λ < 29 um spectrum. The JWST is being developed by NASA, in partnership with the European and Canadian Space Agencies, as a general user facility with science observations to be proposed by the international astronomical community in a manner similar to the Hubble Space Telescope. Technology development and mission design are complete. Construction, integration and verification testing is underway in all areas of the program. The JWST is on schedule for launch during 2018. This science case forms the basis from which detailed science and mission requirements were derived to guide engineering design and development of the JWST as a research tool. The science observations that are implemented by the JWST will be proposed by the international astronomical community in response to annual peer reviewed proposal opportunities (Rigby 2012). The discovery potential of the JWST relative to other concurrent facilities is discussed in Thronson, Stiavelli, and Tielens 2009. The emergence of the first sources of light in the universe marks the end of the "Dark Ages" in cosmic history (Rees 1997). The ultraviolet radiation field produced by these sources created the ionization that is observed in the local intergalactic medium (IGM). The JWST design provides unique capability to address key questions about this era in cosmic evolution including: what is the nature of the first galaxies; how and when did ionization of the space between them occur; and what sources caused the ionization? The JWST architecture is primarily shaped by requirements associated with answering the above questions.In contrast to the Hubble Space Telescope (HST), the JWST is designed as an infrared optimized telescope to observe the redshifted visible and ultraviolet radiation from the first galaxies and supernovae of the first stars. To achieve the nJy sensitivity needed to observe this era (z ~ 6-20), the observatory must have a telescope aperture that is larger in diameter than the largest rocket faring, and the entire optical system must be cooled to ~40-50 K. Finally, the resulting large deployable cryogenic telescope must achieve HST-like angular resolution, but at a 4X longer wavelength thus, also necessitating a large diameter telescope aperture. The major observatory design features (Table 1, Figure 1) trace directly from these requirements and differ markedly from those of the HST.