Optical nanoparticles: synthesis and biomedical application

Tran, Huyen T. T.; Nghiem, Thi Ha Lien; Vu, Thi Thuy Duong; Ha, Chu Viet; Le, Quang Huan; Hoang, Thi My Nhung; Nguyen, Lai Thanh; Pham, Duc Minh; Tong, Kim Thuan; Hoa, Quang; Vu, Duong; Nguyễn, Trọng Nghĩa; Pham, M.T.; Duong, Cao Nguyen; Tran, Thanh T.; Vu, Van Son; Nguyen, Thi Thuy; Tran, Anh Duc; Trinh, Thi Thuong

doi:10.1088/2043-6262/6/2/023002

Cited by 11 publications

(2 citation statements)

References 32 publications

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“…A significant progress in the research on silica-based optical nanoparticles for biomedical applications was achieved by Tran H N et al [20]. This article is a review of their research results.…”

Section: Scientific Achievementsmentioning

confidence: 97%

Advances in Research on Biomedical Nanomaterials in Vietnam

Nguyen

2018

OAJBEB

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The present article is a concise review on the application -oriented basic research on nanomedicine in Vietnam during the 5-year period 2012-2016. The content of review includes following topics: biomedical utilization of targeting folate-decorated paclitaxel-loaded PLA-TPGS nanomaterial, dendrimer-based anticancer drug, special drug delivery nanosystems, various utilization of nanocurcumin in nanomedicine, biosensor and biosensing methods, and antibacterial activity of several types of nanoparticles.

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Section: Scientific Achievementsmentioning

confidence: 97%

Advances in Research on Biomedical Nanomaterials in Vietnam

Nguyen

2018

OAJBEB

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Section: Fundamentals and Fabrication Of Nmnpsmentioning

confidence: 99%

Noble-Metal Nanoparticle-Based Colorimetric Diagnostic Assays for Point-of-Need Applications

Nilghaz

Mousavi

Tian

et al. 2021

ACS Appl. Nano Mater.

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Noble-metal nanoparticles (NMNPs) have unique properties beneficial for the development of novel reporting technologies to enhance the detection sensitivity and specificity of clinically validated biomarkers. Unique size-and shape-dependent optical, catalytic, and magnetic properties of NMNPs have enabled significant advances in biosensing due to facilitation of colorimetric detection, localized surface plasmon resonance, fluorescence enhancement/quenching, surface-enhanced Raman scattering, electrochemical activity, etc. Among these, the colorimetric detection method is highly attractive for use in point-of-need diagnostic applications in which color changes in the presence of biomarkers can be directly observed with the naked eye without the requirement of any equipment. This capability fulfills one of the main requirements set by the World Health Organization to provide people living in remote/regional/low-resource settings access to effective and comprehensive primary care. Although there are many scientific publications, the commercialization of NMNP-based colorimetric diagnostic assays for point-of-need applications is lagging mainly because of the lack of knowledge related to NMNPs in dealing with biological samples and sensitivity of the tests required for the real-world applications. Herein, we provide a critical review of the fundamentals of NMNPs and the recent progress in their usage for monitoring and detecting clinically relevant biomarkers in biological samples at the point-of-need to scientifically assess the benefits and limitations of this technology. We then compare the methods employed to enhance the sensitivity of colorimetric assays in detecting clinically validated target biomarkers in body fluids. Finally, we investigate the future trends and strategies that deserve more research to increase the successful commercialization of these assays.

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Recent Advances in Tracking the Transplanted Stem Cells Using Near‐Infrared Fluorescent Nanoprobes: Turning from the First to the Second Near‐Infrared Window

Chen

Zhang

et al. 2018

Adv Healthcare Materials

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Stem cell-based regenerative medicine has attracted tremendous attention for its great potential to treat numerous incurable diseases. Tracking and understanding the fate and regenerative capabilities of transplanted stem cells is vital for improving the safety and therapeutic efficacy of stem cell-based therapy, therefore accelerating the clinical application of stem cells. Fluorescent nanoparticles (NPs) have been widely used for in vivo tracking of the transplanted stem cells. Among these fluorescent NPs, near-infrared (NIR) NPs have greatly improved the sensitivity, tissue penetration depth, spatial and temporal resolutions of the fluorescence imaging-based stem cell tracking technologies due to the reduced absorption, scattering, and autofluorescence of NIR fluorescence in tissues. Here, this review summarizes the recent studies regarding the tracking of transplanted stem cells using NIR NPs and emphasizes the recent advances of fluorescence imaging in the second NIR window (NIR-II, 1000-1700 nm). Furthermore, the challenges and future prospects of the NIR NP-based technologies are also discussed.

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Optical nanoparticles: synthesis and biomedical application

Cited by 11 publications

References 32 publications

Advances in Research on Biomedical Nanomaterials in Vietnam

Advances in Research on Biomedical Nanomaterials in Vietnam

Noble-Metal Nanoparticle-Based Colorimetric Diagnostic Assays for Point-of-Need Applications

Recent Advances in Tracking the Transplanted Stem Cells Using Near‐Infrared Fluorescent Nanoprobes: Turning from the First to the Second Near‐Infrared Window

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