Optical Nanobiosensing of Stibogluconate in Plasma and Urine Using Green Synthesized Fluorescent Carbon Nanodots

Talaat, Wael; Hassan, Asaad F.

doi:10.1007/s10812-021-01188-2

Cited by 2 publications

(4 citation statements)

References 30 publications

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“…Luminescent CDs were synthesized from garlic peels through a green and eco-friendly manner [ 10 , 11 ]. They were fully characterized as illustrated in Additional file 1 and utilized as sensing probe to detect and quantify two nitrogenous non-fluorophoric drugs; azalide antibiotic, AZN and anti-parkinsonism, RSGL.…”

Section: Resultsmentioning

confidence: 99%

“…Carbon dots were synthesized and all characterization techniques in addition to quantum yield were done and previously reported [ 10 ].…”

Section: Resultsmentioning

confidence: 99%

“…This article enfolds the direct use of green synthesized CDs [ 10 ] as spectrophotometric and fluorescent probes for both drugs’ analysis. The used nano CDs were already synthesized from garlic peels, as natural precursor, as described by Gaber et al [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

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Carbon dots as fluorescent nanoprobes for assay of some non-fluorophoric nitrogenous compounds of high pharmaceutical interest

Moustafa

Talaat

Youssef

et al. 2023

Beni-Suef Univ J Basic Appl Sci

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Background Carbon dots, CDs, have excellent photoluminescence properties, good biocompatibility, low toxicity and good light stability. The optical, magnetic and electronic properties of CDs make them a hugely relevant tool to be used in pharmaceutical analysis, bioimaging, drug delivery, and other fields. The fluorescence of carbon nanodots makes it suitable for assay of some nitrogenous compounds of high pharmaceutical interest. In this work, we develop simple, fast and green spectrophotometric methods for quantification of Azithromycin and Rasagiline mesilate using synthesized fluorescent CDs from garlic peels. Results The spectrometric methods depend on stoichiometric reactions of both drugs with fluorescent CDs. Carbon dots exhibit a declared absorption peak λmax at 238 nm and potent fluorimetric emission at λem 528 nm, upon excitation at λex 376 nm. Drugs’ concentrations in ppm are efficiently calculated using Stern–Volmer Equation. Decrease in fluorescence (ΔF = Fo − F) and the F-ratio values are linearly correlated to molar concentration of each quencher (drug). A significant linear diminish in the dots’ measured absorbance and fluorimetric emission values was observed. Validation of all the developed methods was according to the ICH guidelines. Conclusions In a new way, this work successfully indicates, spectrometric methods for rapid detection of two non-fluorophoric nitrogenous compounds using potent carbon nanodots. Consequently, these green developed methods offer several benefits as simplicity, ease of quantification, accuracy and precision that encourage the application of the developed methods in routine analysis of Azithromycin and Rasagiline mesilate in quality control laboratories as analytical tool.

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Section: Resultsmentioning

confidence: 99%

“…Carbon dots were synthesized and all characterization techniques in addition to quantum yield were done and previously reported [ 10 ].…”

Section: Resultsmentioning

confidence: 99%

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Carbon dots as fluorescent nanoprobes for assay of some non-fluorophoric nitrogenous compounds of high pharmaceutical interest

Moustafa

Talaat

Youssef

et al. 2023

Beni-Suef Univ J Basic Appl Sci

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“…Positively charged amino groups in the carbon dots that were synthesized were thought to be the triggering factor behind the antibacterial activity of C-dots, leading to bacterial mortality and significant damage to the membrane (6,14) . Moreover, a detailed summary of the recently published pharmaceutical applications of Quantum dots (QDs) is demonstrated in Table 2 (16) Stibogluconate used as anti-leishmaniasis drug Fluorescent carbon nanodots prepared from a green source of carbon atoms (garlic peels) 0.01-0.10 μg/ mL 0.003 μg/ mL Fluorimetric determination by the quenching effect of antimony found in stibogluconate drugs.…”

Section: Microorganisms Eradicationmentioning

confidence: 99%

Updated review on carbon dots: their synthesis, characterization and analytical applications

Elnaggar,

Elbardisy,

El-Yazbi

et al. 2024

Journal of Advanced Pharmaceutical Sciences

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One of the most significant advancements in the rapidly expanding field of nanotechnology is colloidal semiconductor nanocrystals, often known as quantum dots. Originally suggested as fluorescent biological markers, they are now discovering significant new applications in analytical chemistry owing to their promising optical, structural, and electrical properties. Carbon dots have attracted a lot of attention lately because of their sustainability, strong biocompatibility, water solubility, low cost of manufacture, and superior chemical stability. Two main methods are used to synthesize carbon dots; the first method is top-down technique while the second method is bottom-up technique. Enhancing the photoluminescence, electrical, and structural properties of carbon dots can be achieved via a dependable and versatile method called hetero-atom doping. Carbon dots are used in versatile fields such as; imaging, sensing, cancer treatment, drug quantitation, gene therapy, photodynamic therapy, photothermal therapy, and microorganism eradication. An overview of recent applications of quantum dots from 2011 to 2024 will be presented in this review, which has 50 references.

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Optical Nanobiosensing of Stibogluconate in Plasma and Urine Using Green Synthesized Fluorescent Carbon Nanodots

Cited by 2 publications

References 30 publications

Carbon dots as fluorescent nanoprobes for assay of some non-fluorophoric nitrogenous compounds of high pharmaceutical interest

Carbon dots as fluorescent nanoprobes for assay of some non-fluorophoric nitrogenous compounds of high pharmaceutical interest

Updated review on carbon dots: their synthesis, characterization and analytical applications

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