Optical measures of cerebral arterial stiffness are associated with white matter signal abnormalities and cognitive performance in normal aging

Tan, Chin Hong; Low, Kathy A.; Chiarelli, Antonio Maria; Fletcher, Mark A.; Navarra, Riccardo; Burzyńska, Agnieszka; Kong, Tania S.; Zimmerman, Benjamin; Maclin, Edward L.; Sutton, Bradley P.; Gratton, Gabriele; Fabiani, Monica

doi:10.1016/j.neurobiolaging.2019.08.004

Cited by 27 publications

(22 citation statements)

References 71 publications

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“…Altered brain physiology, along with disturbances in the function and synchronization of the circadian system, significantly increase the prevalence of neurodegeneration, neurobehavioral deficits, and cognitive aging [ 7 , 8 ]. Research documents that normal cognitive aging involves synaptic changes and decreased neuronal plasticity of the cortex and hippocampus, which directly accelerate declines in memory, reasoning, and speed; these alterations may start from early adulthood [ 9 , 10 ].…”

Section: An Overview Of Cognitive Agingmentioning

confidence: 99%

“…BDNF, especially in the hippocampus, plays a major role in the regulation of processes involved in learning and memory, such as long-term potentiation, synaptic plasticity, axonal sprouting, and proliferation of dendritic arbor, mainly through its interaction with Trk B receptor [ 9 ]. Polymorphisms of BDNF have been reported to be associated with AD [ 140 , 141 ].…”

Section: Mechanisms Underlying Effects Of Rj On Cognition and Ad-rmentioning

confidence: 99%

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Royal Jelly as an Intelligent Anti-Aging Agent—A Focus on Cognitive Aging and Alzheimer’s Disease: A Review

Ali

2020

Antioxidants

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The astronomical increase of the world’s aged population is associated with the increased prevalence of neurodegenerative diseases, heightened disability, and extremely high costs of care. Alzheimer’s Disease (AD) is a widespread, age-related, multifactorial neurodegenerative disease that has enormous social and financial drawbacks worldwide. The unsatisfactory outcomes of available AD pharmacotherapy necessitate the search for alternative natural resources that can target various the underlying mechanisms of AD pathology and reduce disease occurrence and/or progression. Royal jelly (RJ) is the main food of bee queens; it contributes to their fertility, long lifespan, and memory performance. It represents a potent nutraceutical with various pharmacological properties, and has been used in a number of preclinical studies to target AD and age-related cognitive deterioration. To understand the mechanisms through which RJ affects cognitive performance both in natural aging and AD, we reviewed the literature, elaborating on the metabolic, molecular, and cellular mechanisms that mediate its anti-AD effects. Preclinical findings revealed that RJ acts as a multidomain cognitive enhancer that can restore cognitive performance in aged and AD models. It promotes brain cell survival and function by targeting multiple adversities in the neuronal microenvironment such as inflammation, oxidative stress, mitochondrial alterations, impaired proteostasis, amyloid-β toxicity, Ca excitotoxicity, and bioenergetic challenges. Human trials using RJ in AD are limited in quantity and quality. Here, the limitations of RJ-based treatment strategies are discussed, and directions for future studies examining the effect of RJ in cognitively impaired subjects are noted.

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Section: An Overview Of Cognitive Agingmentioning

confidence: 99%

Section: Mechanisms Underlying Effects Of Rj On Cognition and Ad-rmentioning

confidence: 99%

Royal Jelly as an Intelligent Anti-Aging Agent—A Focus on Cognitive Aging and Alzheimer’s Disease: A Review

Ali

2020

Antioxidants

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“…Approximately 10% of infants are born preterm (24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37) weeks of gestational age, wGA 1 ) in the USA, and around a quarter of them present neurodevelopmental sequelae. The survival rate of extremely preterm infants (<28 wGA) has increased significantly over the last two decades.…”

Section: Introductionmentioning

confidence: 99%

Assessment of cerebrovascular development and intraventricular hemorrhages in preterm infants with optical measures of the brain arterial pulse wave

Chiarelli

Mahmoudzadeh

Low

et al. 2017

J Cereb Blood Flow Metab

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Preterm infants (born at 24-34 weeks of gestational age) suffer from a high incidence of neurological complications. Cerebrovascular lesions (intraventricular hemorrhages, IVH, and ischemic injury) due to the immaturity of the vascular system and its inability to adapt to the extra-uterine environment are the major causes of adverse neurological outcomes. We investigated the feasibility of assessing cerebrovascular status in preterm infants using a novel non-invasive optical procedure, pulse-DOT, usable within the incubator. Pulse-DOT, validated in adults, provides estimates of cerebral arterial status based on optical measurements of the pulse wave. These measurements are taken with a high-density optode montage and provide accurate spatial and temporal information. We found that two pulse parameters (pulse relaxation function, PReFx, and pulse rise time, PRT) in the investigated frontotemporal region, correlated with infant's age at recording, indexing cerebrovascular development. Moreover, PRT differentiated infants with and without concurrent IVH (sensitivity = 100%, specificity = 70%). These values are at least as high as those of the resistivity index obtained with transcranial Doppler of the middle cerebral artery, the current clinical method of choice for investigating arterial elasticity in preterm infants. This makes pulse-DOT a promising tool for investigating cerebrovascular risk factors and related pathologies in preterm infants.

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“…Some of her early work in this line of research (Fabiani & Friedman, ) showed that older adults' P3 responses in an auditory oddball paradigm differ quite dramatically from those of younger adults, likely reflecting older adults' decreasing ability to maintain representations in working memory. More recently, Monica and her team have provided compelling evidence that age‐related cognitive decline is closely linked to cerebral arterial elasticity (Tan et al, in press). Specifically, older adults whose cerebral arteries are relatively stiff, a symptom of poor cardiorespiratory fitness, show more white matter lesions—which in turn are associated with greater decline in cognitive abilities.…”

mentioning

confidence: 99%

“…To develop an entirely new way of measuring the functioning of the human brain in real time, especially early in one's career, when such endeavors are particularly risky, is truly extraordinary. In recent years, Monica and Gabriele have expanded the capacity of diffuse optical imaging to also characterize neurovascular health, especially arterial stiffness Tan et al, ), a technique for which they and their longtime collaborators, Kathy Low and Ed Maclin, hold a patent (Gratton, Fabiani, Low, & Maclin, 2015).…”

mentioning

confidence: 99%

For distinguished contributions to psychophysiology: Monica Fabiani and Gabriele Gratton

Bartholow

2020

Psychophysiology

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Optical measures of cerebral arterial stiffness are associated with white matter signal abnormalities and cognitive performance in normal aging

Cited by 27 publications

References 71 publications

Royal Jelly as an Intelligent Anti-Aging Agent—A Focus on Cognitive Aging and Alzheimer’s Disease: A Review

Royal Jelly as an Intelligent Anti-Aging Agent—A Focus on Cognitive Aging and Alzheimer’s Disease: A Review

Assessment of cerebrovascular development and intraventricular hemorrhages in preterm infants with optical measures of the brain arterial pulse wave

For distinguished contributions to psychophysiology: Monica Fabiani and Gabriele Gratton

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