Optical measurement of transient ultrasonic shock waves

Jacob, Xavier; Barrière, Christophe; Takatsu, R.; Montaldo, Gabriel; Royer, D.

doi:10.1109/ultsym.2004.1417666

Cited by 5 publications

(3 citation statements)

References 9 publications

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“…The recorded peak to peak voltage (VPP) was 139±26 V for monkey Y and 56±15 V for monkey L. The calibration of the transducer in water with a custom built heterodyne interferometer (28) led to a linear relationship between VPP and peak negative pressure The ultrasound was directly applied to previously shaved skin. A coupling cone filled with water ensured ultrasonic coupling between the transducer and the animal's head.…”

Section: Focused Ultrasoundmentioning

confidence: 99%

Transcranial ultrasonic stimulation modulates single-neuron discharge in macaques performing an antisaccade task

et al. 2017

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Our study demonstrates that the neuromodulatory effects of non-invasive focused ultrasound can be assessed in real time in awake behaving monkeys by recording discharge activity from a brain region reciprocally connected with the stimulated region. The study opens the door for further parametric studies for fine-tuning the ultrasonic parameters. The ultrasonic effect could indeed be quantified based on the direct measurement of the intensity of the modulation induced on a single neuron in a freely performing animal. The technique should be readily reproducible in other primate laboratories studying brain function, both for exploratory and therapeutic purposes and to facilitate the development of future clinical TUS devices.

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Section: Focused Ultrasoundmentioning

confidence: 99%

Transcranial ultrasonic stimulation modulates single-neuron discharge in macaques performing an antisaccade task

et al. 2017

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“…The calibration was performed by measuring the ultrasonic displacement at focus using a heterodyne interferometer. The experimental set-up used was described previously (Jacob et al 2004), and the digital demodulation scheme was used here. The pressure waveforms were derived from the measured ultrasonic displacement assuming that the wavefront of the wave was locally planar.…”

Section: Calibration For the Single-element Transducermentioning

confidence: 99%

In vivobubble nucleation probability in sheep brain tissue

et al. 2011

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Gas nuclei exist naturally in living bodies. Their activation initiates cavitation activity, and is possible using short ultrasonic excitations of high amplitude. However, little is known about the nuclei population in vivo, and therefore about the rarefaction pressure required to form bubbles in tissue. A novel method dedicated to in vivo investigations was used here that combines passive and active cavitation detection with a multi-element linear ultrasound probe (4-7 MHz). Experiments were performed in vivo on the brain of trepanated sheep. Bubble nucleation was induced using a focused single-element transducer (central frequency 660 kHz, f-number = 1) driven by a high power (up to 5 kW) electric burst of two cycles. Successive passive recording and ultrafast active imaging were shown to allow detection of a single nucleation event in brain tissue in vivo. Experiments carried out on eight sheep allowed statistical studies of the bubble nucleation process. The nucleation probability was evaluated as a function of the peak negative pressure. No nucleation event could be detected with a peak negative pressure weaker than -12.7 MPa, i.e. one order of magnitude higher than the recommendations based on the mechanical index. Below this threshold, bubble nucleation in vivo in brain tissues is a random phenomenon.

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“…The upper measurable acoustic pressure is limited by the fundamental frequency f 0 , the carrier frequency and the resultant bandwidth of the detection system B. The phase reconstruction procedure remains valid for the following criterion [89,90].…”

Section: Optical Interferometrymentioning

confidence: 99%

Review of field characterization techniques for high intensity therapeutic ultrasound

Xing

Wilkens

2021

Metrologia

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High-intensity therapeutic ultrasound (HITU) is a minimally invasive and non-ionizing medical procedure used to combat cancers. Faithful characterization of HITU fields is fundamental to ensure patient safety and clinical efficiency. However, standardized quality assurance protocols have not yet been established for HITU, which is a prerequisite for the wide acceptance of HITU as a therapeutic modality. This review discusses the challenges in the acoustic output characterization of HITU and the solutions that have been proposed to overcome this issue. The purpose of this review is to discuss the state of art of the metrological techniques, and invoke new ideas to prompt further development of HITU usage and characterization techniques, to ensure the safe and effective usage of therapeutic ultrasound.

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Optical measurement of transient ultrasonic shock waves

Cited by 5 publications

References 9 publications

Transcranial ultrasonic stimulation modulates single-neuron discharge in macaques performing an antisaccade task

Transcranial ultrasonic stimulation modulates single-neuron discharge in macaques performing an antisaccade task

In vivobubble nucleation probability in sheep brain tissue

Review of field characterization techniques for high intensity therapeutic ultrasound

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