Optical mammography: a new technique for visualizing breast lesions in women presenting non palpable BIRADS 4-5 imaging findings: preliminary results with radiologic-pathologic correlation

Abstract

The purpose of this prospective study is to determine the diagnostic accuracy of near-infrared breast optical absorption imaging in patients with Breast Imaging Reporting and Data System (BIRADS) 45 non-palpable lesions scheduled for biopsy, using pathology after core or excisional biopsy as a reference. The patient's breast was positioned onto a panel of red light-emitting diodes (640 nm). A soft membrane was inflated to exert a uniform pressure on the breast. Transmitted light was detected using a CCD camera. The entire acquisition sequence took 1 minute. Image processing generated dynamic images displayed in colour scale, to reveal time-dependent changes in the transmitted light intensity caused by the pressure change. Dynamic curves were classified in two categories: consistently decreasing intensity suspicious for malignancy, and sinusoidal increasing intensity considered as benign. Seventy-eight women consulting for non-palpable breast lesions were initially included in the study. An imaginghistology correlation was obtained for seventy-two patients, the remaining six patients were excluded for technical optical scan reasons. We experienced an overall sensitivity of 73% and specificity of 38%, the false negative results being mainly small size (510 mm) infiltrating malignant lesions and ductal carcinoma in situ (DCIS). False positive results were seen in benign proliferative lesions. Dynamic optical breast imaging is a novel, low-cost, noninvasive technique yielding a new type of information about the physiology of breast lesions. Absorption is due to haemoglobin and its products, therefore reflecting the angiogenic status of breast tumours.

US-guided diffused optical tomography: a promising functional imaging technique in breast lesions

“…Because of the poor spatial resolution caused by intense light scattering in soft tissues, optical tomography alone has not been widely used in clinical studies. With the improvements in technology and mathematical techniques, DOT combined with other imaging techniques such as US [2][3][4], X-mammography [5] or MRI [6,7] shows promise in overcoming these problems and has generated considerable interest. The aim of our study was to investigate prospectively the feasibility of combining US with DOT in differentiating breast lesions and to evaluate its clinical efficacy.…”

Implicit and explicit prior information in near-infrared spectral imaging: accuracy, quantification and diagnostic value

“…Incorporating viscoelastic tissue modelling in NIRS is an approach that has seen some recent activity. Dynamic measurements induced by changes in pressure applied to the tissue can provide a rich dataset for robust, often ratiometric, interpretation of oxygen saturation and total haemoglobin values [106][107][108][109][110][111]. These mechanical models are almost uniformly applied in post-processing or forward modelling [112], owing to the complexity of solving the viscoelastic problem in irregular domains.…”

Electrical Impedance Tomography as a Primary Screening Technique for Breast Cancer Detection

“…Some evidence has been found that malignant breast tumours have lower electrical impedance than surrounding normal tissues (Malich et al, 2001;Prasad et al, 2008). This observation has led to the proposal that electrical impedance could be used as an indicator for breast cancer detection (Cherepenin et al, 2001;Cherepenin et al, 2002;Athanasiou et al, 2007).…”