We present an electro-optic wide-field method to enable fluorescence lifetime microscopy (FLIM) with high throughput and single-molecule sensitivity. Resonantly driven Pockels cells are used to efficiently capture nanosecond image dynamics on standard camera sensors. Images are gated at 39 MHz with 16 dB extinction and 86% modulation depth, allowing lifetimes to be estimated with sensitivity 1.9 times the shot-noise limit and without restricting photon throughput. High throughput is shown by acquiring FLIM images with millisecond exposure and > 10 8 photons per image. High sensitivity is shown through wide-field lifetime imaging of single-molecule populations and dynamics. Using both the throughput and sensitivity of the technique, we enable the first combination of wide-field lifetime imaging with single-molecule localization microscopy. We further demonstrate lifetime imaging of single-molecule FRET and multi-parameter imaging of molecular binding events combining intensity, lifetime, and polarization. More generally, resonant electro-optic imaging can provide lifetime contrast in any wide-field method and will enable nanosecond time-domain measurements in microscopy.