Optical Instrumentation for the Measurement of Blood Perfusion, Concentration, and Oxygenation in Living Microcirculation

Leahy, Martin J.; O’Doherty, Jim

doi:10.1002/9783527634286.ch18

Cited by 1 publication

(2 citation statements)

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“…Such preparations are usually required for studying the microcirculation of internal organs, tumor development, angiogenesis, inflammation, thrombosis, and the progression of infection. FCM uses acute preparations in rodent models to expose the vessels of mesentery, skin flap, bone, brain, liver, kidney, lungs, and cremaster muscle (109, 118). Less invasive are models of eye conjunctiva (99), iris (119), and retina (59, 60), which are directly applicable in humans.…”

Section: Animal Models and Potential For Humansmentioning

confidence: 99%

“…Cell focusing in vivo in native lymph flow was demonstrated using lymph valve as a natural nozzle (26). A few other groups and researchers, including Stephen Morgan (University of Nottingham), Vyacheslav Kalchenko (Weizmann Institute of Science), and Gerard L. Coté (Texas A&M University) made a brilliant input in the problem of the label‐free imaging of blood flow and measurement of flow velocity and oxygenation (16, 17, 111, 112, 113–119), which are summarized in (109, 110) and partly presented in this issue (17).…”

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confidence: 99%

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In vivo flow cytometry: A horizon of opportunities

2011

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Flow cytometry has been a fundamental tool of biological discovery for many years. Invasive extraction of cells from a living organism, however, may lead to changes in cell properties and prevents studying cells in their native environment. These problems can be overcome by use of in vivo flow cytometry which provides detection and imaging of circulating normal and abnormal cells directlyin blood or lymph flow. The goal of this mini-review is to provide a brief history, features and challenges of this new generation of flow cytometry methods and instruments. Spectrum of possibilities of in vivo flow cytometry in biological science (e.g., cell metabolism, immune function, or apoptosis) and medical fields (e.g., cancer, infection, cardiovascular disorder) including integrated photoacoustic-photothermal theranostics of circulating abnormal cells are discussed with focus on recent advances of this new platform.

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