Optical imaging techniques for the study of malaria

Cho, Sangyeon; Kim, Soomin; Kim, Young-Chan; Park, YongKeun

doi:10.1016/j.tibtech.2011.08.004

Cited by 76 publications

(66 citation statements)

References 66 publications

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“…Independent quantification of malaria used two standard microscopy-based methods: (i) Giemsa staining (17) (Fig. S7, I and II) was used to identify the ring and schizont stages of malaria parasite development and measure the level of parasitemia.…”

Section: Methodsmentioning

confidence: 99%

Hemozoin-generated vapor nanobubbles for transdermal reagent- and needle-free detection of malaria

Lukianova‐Hleb¹,

Campbell

Constantinou³

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

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Successful diagnosis, screening, and elimination of malaria critically depend on rapid and sensitive detection of this dangerous infection, preferably transdermally and without sophisticated reagents or blood drawing. Such diagnostic methods are not currently available.Here we show that the high optical absorbance and nanosize of endogenous heme nanoparticles called "hemozoin," a unique component of all blood-stage malaria parasites, generates a transient vapor nanobubble around hemozoin in response to a short and safe near-infrared picosecond laser pulse. The acoustic signals of these malaria-specific nanobubbles provided transdermal noninvasive and rapid detection of a malaria infection as low as 0.00034% in animals without using any reagents or drawing blood. These on-demand transient events have no analogs among current malaria markers and probes, can detect and screen malaria in seconds, and can be realized as a compact, easy-to-use, inexpensive, and safe field technology.

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Section: Methodsmentioning

confidence: 99%

Hemozoin-generated vapor nanobubbles for transdermal reagent- and needle-free detection of malaria

Lukianova‐Hleb¹,

Campbell

Constantinou³

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

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“…It is, therefore, desirable to develop faster, noninvasive and innovative automated methods which are independent of operator bias and skill. With these requirements in mind, there is considerable interest currently in examining the potential of the elastic light scattering technique as an alternative to conventional methods for quick and reliable diagnosis of malaria [2][3][4][5][6][7][8][9][10][11][12].…”

Section: \ Introductionmentioning

confidence: 99%

Theoretical models for near forward light scattering by aPlasmodium falciparuminfected red blood cell

Sharma

2012

Journal of Modern Optics

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A number of experimental elastic light scattering studies have been performed in the past few years with the aim of developing automated in vivo tools for differentiating a healthy red blood cell from a Plasmodium falciparum infected cell. This paper examines some theoretical aspects of the problem. An attempt has been made to simulate the scattering patterns of healthy as well as infected individual red blood cells. Two models, namely, a homogeneous sphere model and a coated sphere model have been considered. The scattering patterns predicted by these models are examined. A possible method for discriminating infected red blood cells from healthy ones has been suggested.

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“…In the future, the aFTLS technique could be used in combination with other existing optical imaging techniques to better study other RBC related diseases, for example, to understand the protective mechanism of sickle RBCs against infection of malaria parasite. 25 …”

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confidence: 99%