Optical Imaging as Auxiliary Tool in Skin Cancer Diagnosis

Pratavieira, Sebastião; Andrade, Cintia Teles de; Sálvio, Ana Gabriela; Bagnato, Vanderlei Salvador; Kurachi, C.

doi:10.5772/25465

Cited by 14 publications

(16 citation statements)

References 40 publications

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“…The corneum pseudocysts, a tissue structure that differentiates the SK from melanoma, become evident in autofluorescence images [22,31]. In melanoma lesions, the autofluorescence pattern is an evident LOF, visualized as a dark area without any fluorescent spots.…”

Section: Discussionmentioning

confidence: 99%

Identification of skin lesions through aminolaevulinic acid-mediated photodynamic detection

Andrade

Vollet‐Filho

Sálvio

et al. 2014

Photodiagnosis and Photodynamic Therapy

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Section: Discussionmentioning

confidence: 99%

Identification of skin lesions through aminolaevulinic acid-mediated photodynamic detection

Andrade

Vollet‐Filho

Sálvio

et al. 2014

Photodiagnosis and Photodynamic Therapy

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“…Optical Imaging methods have caused the big evolution in current medical field for lesion detection and discrimination. [1]. Optical imaging is of many types namely, optical tomography, bioluminescence etc [2].…”

Section: Need For Optical Imagingmentioning

confidence: 99%

Detection of Skin Cancer using Optical Method

2019

IJITEE

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Skin is the one of the most important organ present in our body that does some of the important functions like protection, temperature regulation etc. Due to some conditions, skin is affected by many abnormalities. The abnormalities may be smaller or larger, which depends on the damage caused to the skin. Some abnormalities of skin are irritations, allergic reactions, swelling etc. One of the most major problems that affect the skin completely is of skin cancer. Skin cancer is the most common type of cancer that affects the 40% of people in all over world. It may be caused due to several factors like genetic, working in hazardous chemical areas, exposure to sun, repeated X-ray exposures etc. All of these factors affects the skin and causes skin cancer. Skin biopsy is a major technique used at present to detect all types of skin cancers. As this biopsy method is invasive, and takes more time to check the cancer tissue, we are using this optical method for detection of skin cancer. Optical imaging is the upcoming technology that plays the major role in all fields. In this method Near Infra-Red (NIR) light source is passed into the affected skin region. The transimpedance amplifier is used to amplify the output from photodiodes. Then the output from the photodiodes is connected to the Digital Storage Oscilloscope (DSO) in which the waveform shows the variations due to skin cancer.

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“…The fluorescence probe is an optical setup composed of LED arrays, the LED electronics, light collimator components, a dichroic mirror, and a longpass filter (similar setup is found elsewhere [7]). Those LED arrays emit at about (400±10) nm, with maximum output power of 50±10 mW/cm².…”

Section: Fluorescence Visualization Probementioning

confidence: 99%

Single LED-based device to perform widefield fluorescence imaging and photodynamic therapy

Grecco

Buzzá

Stringasci

et al. 2015

Biophotonics South America

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Photodynamic therapy (PDT) is a treatment modality that can be indicated for several cancer types and precancer lesions. One of the main applications of PDT is the treatment of superficial skin lesions such as basal cell carcinoma, Bowen's disease and actinic keratosis. Three elements are necessary in PDT, a photosensitizer (PS); light at specific wavelength to be absorbed by the PS, and molecular oxygen. A typical PS used for skin lesion is protoporphyrin IX (PpIX), which is an intrinsic PS; its production is stimulated by a pro-drug, such as 5-aminolevulinic acid (ALA). Before starting a treatment, it is very important to follow up the PpIX production (to ensure that enough PS was produced prior to a PDT application) and, during a PDT session, to monitor its photodegradation (as it is evidence of the photodynamic effect taking place). The aim of this paper is to present a unique device, LINCE (MMOptics -São Carlos, Brazil), that brings together two probes that can, respectively, allow for fluorescence imaging and work as a light source for PDT treatment. The fluorescence probe of the system is optically based on 400 nm LED (light emitting diodes) arrays that allow observing the fluorescence emission over 450 nm. The PDT illumination probe options are constituted of 630 nm LED arrays for small areas and, for large areas, of both 630 nm and 450 nm LED arrays. Joining both functions at the same device makes PDT treatment simpler, properly monitorable and, hence, more clinically feasible. LINCE has been used in almost 1000 PDT treatments of superficial skin lesions in Brazil, with 88.4% of clearance of superficial BCC.

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Optical Imaging as Auxiliary Tool in Skin Cancer Diagnosis

Cited by 14 publications

References 40 publications

Identification of skin lesions through aminolaevulinic acid-mediated photodynamic detection

Identification of skin lesions through aminolaevulinic acid-mediated photodynamic detection

Detection of Skin Cancer using Optical Method

Single LED-based device to perform widefield fluorescence imaging and photodynamic therapy

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