Optical image contrast enhancement in near-field optics induced by water condensation

Douas, M.; Marqués, Manuel I.; Serena, P. A.

doi:10.1016/j.ultramic.2013.05.021

Cited by 3 publications

(1 citation statement)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, at visible and near IR wavelengths (400-1200 nm) light scattering contrast is limited between adjacent tissues [6]. Although, for example, morphological differences between normal and malignant tissues can be obvious at later stages of tumor development, it is challenging to detect early-stage tumors or tumors that are optically similar to surrounding normal tissue [7]. This can be potentially improved by contrast agents to differentiate normal tissue from the pathological lesions exploiting MBs as contrast agents in similar manner as for US imaging contrast enhancement [8].…”

Section: Introductionmentioning

confidence: 99%

Optical Scattering Properties of Intralipid Phantom in Presence of Encapsulated Microbubbles

Assadi

Karshafian

Douplik

2014

International Journal of Photoenergy

View full text Add to dashboard Cite

In imaging, contrast agents are utilized to enhance sensitivity and specificity of diagnostic modalities. In ultrasound imaging, microbubbles (MBs)—a gas-core shell-encapsulated agent—are used clinically as contrast agents. The working hypothesis of this study is that microbubbles can be employed as an intravascular contrast agent in optical imaging systems. In this work, the interaction of light and microbubbles in a turbid medium (intralipid) was investigated, particularly, the effect of MBs on the reduced scattering and absorption coefficients. Diffuse reflectance (DR) and total transmittance (TT) measurements of highly scattering intralipid suspension (0.5–5%) were measured using spectroscopic integrating sphere system in the absence and presence of Definity microbubbles. The optical properties were computed using the inverse adding doubling (IAD) software. The presence of microbubbles increased DR and decreased TT of intralipid phantoms. In the presence of MBs (0.5% volume concentration), the reflectance of the intralipid phantom increased from 35% to 100%. The reduced scattering coefficient increased significantly (30%) indicating potential use of MBs as optical contrast agents in light based modalities.

show abstract

Section: Introductionmentioning

confidence: 99%