Optical fibre probe NIR Raman measurements in ambient light and in combination with a tactile resonance sensor for possible cancer detection

Nyberg, Morgan; Ramser, Kerstin; Lindahl, Olof

doi:10.1039/c3an00243h

Cited by 3 publications

(1 citation statement)

References 22 publications

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“…Recently, a multi-modality probe that combines Raman spectroscopy and tactile resonance technology been developed, with the potential to become a clinical scanning instrument for studying surgical margins during surgery (Nyberg et al 2013. The method is based on an idea of a rotational device into which the surgically removed prostate is inserted and rotated (Astrand et al 2017).…”

Section: Introductionmentioning

confidence: 99%

A tactile resonance sensor for prostate cancer detection – evaluation on human prostate tissue

Lindahl

Bäcklund

Ramser

et al. 2021

Biomed. Phys. Eng. Express

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Prostate cancer surgery risks erectile problems and incontinence for the patient. An instrument for guiding surgeons to avoid nerve bundle damage and ensure complete cancer removal is desirable. We present a tactile resonance sensor made of PZT ceramics, mounted in a 3D motorized translation stage for scanning and measuring tissue stiffness for detecting cancer in human prostate. The sensor may be used during surgery for guidance, scanning the prostate surface for the presence of cancer, indicating migration of cancer cells into surrounding tissue. Ten fresh prostates, obtained from patients undergoing prostate cancer surgery, were cut into 0.5 cm thick slices. Each slice was measured for tissue stiffness at about 25 different sites and compared to histology for validation cancer prediction by stiffness. The statistical analysis was based on a total of 148 sites with non-cancer and 40 sites with cancer. Using a generalized linear mixed model (GLMM), the stiffness data predicted cancer with an area under the curve of 0.74, after correcting for overfitting using bootstrap validation. Mean prostate stiffness on the logarithmic scale (p=0.015) and standardized Z-scores (p=0.025) were both significant predictors of cancer. This study concludes that stiffness measured by the tactile resonance sensor is a significant predictor of prostate cancer with potential for future development towards a clinical instrument for surgical guidance.

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Section: Introductionmentioning

confidence: 99%

A tactile resonance sensor for prostate cancer detection – evaluation on human prostate tissue

Lindahl

Bäcklund

Ramser

et al. 2021

Biomed. Phys. Eng. Express

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Prostate Cancer Detection Using a Combination of Raman Spectroscopy and Stiffness Sensing

et al. 2015

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Dual-modality probe intended for prostate cancer detection combining Raman spectroscopy and tactile resonance technology—discrimination of normal human prostate tissuesex vivo

Nyberg

Jalkanen

Ramser

et al. 2015

Journal of Medical Engineering & Technology

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Prostate cancer is the most common cancer for men in the western world. For the first time, a dual-modality probe, combining Raman spectroscopy and tactile resonance technology, has been used for assessment of fresh human prostate tissue. The study investigates the potential of the dual-modality probe by testing its ability to differentiate prostate tissue types ex vivo. Measurements on four prostates show that the tactile resonance modality was able to discriminate soft epithelial tissue and stiff stroma (p < 0.05). The Raman spectra exhibited a strong fluorescent background at the current experimental settings. However, stroma could be discerned from epithelia by integrating the value of the spectral background. Combining both parameters by a stepwise analysis resulted in 100% sensitivity and 91% specificity. Although no cancer tissue was analysed, the results are promising for further development of the instrument and method for discriminating prostate tissues and cancer.

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Optical fibre probe NIR Raman measurements in ambient light and in combination with a tactile resonance sensor for possible cancer detection

Cited by 3 publications

References 22 publications

A tactile resonance sensor for prostate cancer detection – evaluation on human prostate tissue

A tactile resonance sensor for prostate cancer detection – evaluation on human prostate tissue

Prostate Cancer Detection Using a Combination of Raman Spectroscopy and Stiffness Sensing

Dual-modality probe intended for prostate cancer detection combining Raman spectroscopy and tactile resonance technology—discrimination of normal human prostate tissuesex vivo

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