Optical fiber SPR biosensor complying with a 3D composite hyperbolic metamaterial and a graphene film

Abstract

In the present study, an optical fiber surface plasmon resonance (SPR) biosensor was developed for measuring time- and concentration-dependent DNA hybridization kinetics. Its design complies with a 3D Au / Al 2 O 3 multilayer composite hyperbolic metamaterial (HMM), a graphene film, and a D-shaped plastic optical fiber. According to the numerical simulation and the experimental demonstration, the SPR peak of the designed biosensor can be effectively altered in the range of visible to near-infrared by varying the HMM structure. The sensitivity of the appliance was shown to achieve a value of up to 4461 nm/RIU, allowing its applicability for bulk refractive index sensing. Furthermore, a biosensor designed in this work displayed high-resolution capability (ranging from 10 pM to 100 nM), good linearity, and high repeatability along with a detection limit down to 10 pM, thus suggesting a vast potential for medical diagnostics and clinical applications.

Molecular Plasmonics with Metamaterials

“…This allows the angular detection of large-molecular-weight biomolecules such as Cowpea mosaic virus (5 × 10 6 Da) at concentrations as low as 1 fM. Hyperbolic metamaterial-based biochemical sensors can be further miniaturized by integrating the metamaterials with optical fibers, such as D-shaped fibers. − …”

Effective excitation of bulk plasmon-polaritons in hyperbolic metamaterials for high-sensitivity refractive index sensing

“…Since then, many HMMs and HMs have been proposed for high-sensitivity sensing. [16][17][18][19][20][21] Recently, our research group combined electron beam lithography and electrochemical methods to fabricate an NHMM sensor, achieving a record sensitivity of 41 600 nm RIU À1 . 22 HMMs exhibit anisotropic optical properties and involve complex mode relationships, and the effective excitation of the BPP modes in HMMs for highly sensitive sensing is an important matter.…”

“…Since then, many HMMs and HMs have been proposed for high-sensitivity sensing. 16–21 Recently, our research group combined electron beam lithography and electrochemical methods to fabricate an NHMM sensor, achieving a record sensitivity of 41 600 nm RIU −1 . 22…”

Hyperbolic-Metamaterials-Based SPR Temperature Sensor Enhanced by a Nanodiamond-PDMS Hybrid for High Sensitivity and Fast Response

“…Hyperbolic metamaterials (HMMs) have hyperbolic dispersions by the opposite permittivity components and can be adjusted by changing the periodic structure parameters. , Our previous work demonstrated that coating an HMM onto a side-polishing fiber sensor can effectively improve the SPR sensitivity to 9000 nm per refractive index unit (nm/RIU) with an optimal figure of merit (FOM) of 230.8 RIU –1 . Similarly, Li et al reported that HMM combined with plastic-clad fibers could achieve a sensitivity of 4461 nm/RIU for DNA detection . Although the high RI sensitivities of HMM-based SPR (H-SPR) sensors showed potential for temperature sensing, such reports have rarely been seen yet.…”