Optical fiber SPR biosensor based on gold nanoparticle amplification for DNA hybridization detection

Li, Like; Zhang, Ya‐nan; Zheng, Wanlu; Li, Xuegang; Zhao, Yong

doi:10.1016/j.talanta.2022.123599

Cited by 45 publications

(16 citation statements)

References 41 publications

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“…to generate strong plasma-matter interactions. SPR sensors are sensor probes that generate plasma using metal films and nanostructures and are applied to light fields to detect chemical, physical [ 142 ], biomolecular [ 143 ], DNA [ 41 ], and microbial agents. In order to improve the sensitivity of the sensor, several optical geometries have been studied and developed.…”

Section: Application Of 2d Nanomaterials In the Field Of Optical Fibe...mentioning

confidence: 99%

“…These gratings achieve surface plasmon resonance (SPR) effects and selective or enzymatic coatings, respectively. For sensitive and precise detection of bacterial flora and biomolecules, optical biosensors based on fluorescence [ 35 , 36 , 37 , 38 , 39 ], SPR [ 3 , 5 , 13 , 40 , 41 ], and localized surface plasmon resonance (LSPR) [ 7 , 18 , 42 , 43 ] are currently being reported.…”

Section: Introductionmentioning

confidence: 99%

“…Two-dimensional metal films and three-dimensional (3D) nanoarrays play an important role in enhancing the local electric field of optical fiber structures so they can be used in the development of SPR-based optical fiber biosensors. These sensing systems can detect a large number of molecules of clinical relevance, including glucose [ 56 , 57 ], bacteria [ 58 , 59 ], cancer cells [ 6 , 60 ], dopamine [ 61 , 62 , 63 ], deoxyribonucleic acid (DNA) [ 41 ], and so on. The applications of different types of nanomaterials based on different sensing principles are represented in Figure 1 .…”

Section: Introductionmentioning

confidence: 99%

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Advances in Novel Nanomaterial-Based Optical Fiber Biosensors—A Review

Singh

Wang

et al. 2022

Biosensors

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This article presents a concise summary of current advancements in novel nanomaterial-based optical fiber biosensors. The beneficial optical and biological properties of nanomaterials, such as nanoparticle size-dependent signal amplification, plasmon resonance, and charge-transfer capabilities, are widely used in biosensing applications. Due to the biocompatibility and bioreceptor combination, the nanomaterials enhance the sensitivity, limit of detection, specificity, and response time of sensing probes, as well as the signal-to-noise ratio of fiber optic biosensing platforms. This has established a practical method for improving the performance of fiber optic biosensors. With the aforementioned outstanding nanomaterial properties, the development of fiber optic biosensors has been efficiently promoted. This paper reviews the application of numerous novel nanomaterials in the field of optical fiber biosensing and provides a brief explanation of the fiber sensing mechanism.

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Section: Application Of 2d Nanomaterials In the Field Of Optical Fibe...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Advances in Novel Nanomaterial-Based Optical Fiber Biosensors—A Review

Singh

Wang

et al. 2022

Biosensors

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“…Au nanoparticles (AuNPs) enhanced fiber-optic SPR sensors are a current research hotspot due to their ease of preparation of AuNPs and functionalization of their surfaces. For example, Wang et al deposited multiple layers of AuNPs onto the surface of Au film and demonstrated that the electromagnetic coupling between multiple layers of AuNPs and Au film achieved extremely high detection sensitivity [10].…”

Section: Introductionmentioning

confidence: 99%

Detection of E. coli O157:H7 via GO-modified fiber optic SPR sensor with Au nanoparticle signal amplification

Jiang,

Zhu,

Qian*

et al. 2023

3rd International Conference on Laser, Optics, and Optoelectronic Technology (LOPET 2023)

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Escherichia coli O157:H7 (E. coli O157:H7) is a public health hazard for enteric pathogens. Thus, it is essential to detect E. coli with high sensitivity. In this study, a dual signal enhancement fiber-optic surface plasmon resonance (SPR) sensor is proposed to enhance the sensitivity. The sensor surface was modified by graphene oxide (GO) as the signal enhancement layer and the Au nanoparticles (AuNPs) were used for secondary signal amplification. It can significantly improve the sensitivity by four orders of magnitude compared with the traditional fiber-optic SPR sensor. The limit of detection (LOD) for E. coli O157: H7 was 142 CFU/mL and the detection range was 10 3 -10 7 CFU/mL. The developed sensor has high sensitivity and specificity. Therefore, the sensor may be a potential tool for detecting other biological pathogens.

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“…Various nanoscale materials, such as nanowires [ 12 ], nanotubes [ 13 ], and nanoparticles (including quantum dot) [ 14 , 15 ], exhibit excellent prospects for biosensing applications. In particular, silicon nanowire (SiNW) is a very well-defined and controlled class of nanoscale building blocks, owing to its adaptability for semiconductor-based technology.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of Silicon Nanowire Sensors for Highly Sensitive pH and DNA Hybridization Detection

et al. 2022

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A highly sensitive silicon nanowire (SiNW)-based sensor device was developed using electron beam lithography integrated with complementary metal oxide semiconductor (CMOS) technology. The top-down fabrication approach enables the rapid fabrication of device miniaturization with uniform and strictly controlled geometric and surface properties. This study demonstrates that SiNW devices are well-aligned with different widths and numbers for pH sensing. The device consists of a single nanowire with 60 nm width, exhibiting an ideal pH responsivity (18.26 × 106 Ω/pH), with a good linear relation between the electrical response and a pH level range of 4–10. The optimized SiNW device is employed to detect specific single-stranded deoxyribonucleic acid (ssDNA) molecules. To use the sensing area, the sensor surface was chemically modified using (3-aminopropyl) triethoxysilane and glutaraldehyde, yielding covalently linked nanowire ssDNA adducts. Detection of hybridized DNA works by detecting the changes in the electrical current of the ssDNA-functionalized SiNW sensor, interacting with the targeted ssDNA in a label-free way. The developed biosensor shows selectivity for the complementary target ssDNA with linear detection ranging from 1.0 × 10−12 M to 1.0 × 10−7 M and an attained detection limit of 4.131 × 10−13 M. This indicates that the use of SiNW devices is a promising approach for the applications of ion detection and biomolecules sensing and could serve as a novel biosensor for future biomedical diagnosis.

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Optical fiber SPR biosensor based on gold nanoparticle amplification for DNA hybridization detection

Cited by 45 publications

References 41 publications

Advances in Novel Nanomaterial-Based Optical Fiber Biosensors—A Review

Advances in Novel Nanomaterial-Based Optical Fiber Biosensors—A Review

Detection of E. coli O157:H7 via GO-modified fiber optic SPR sensor with Au nanoparticle signal amplification

Fabrication of Silicon Nanowire Sensors for Highly Sensitive pH and DNA Hybridization Detection

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