Optical emissions of chitosan modified LaAlO3: Bi3+, Tb3+ nanoparticles for bio labeling and drug delivery to breast cancer cells

Shaik, Esub Basha; Pindiprolu, Sai Kiran S. S.; Phanikumar, Chirravuri S.; Samuel, Temesgen; Kumar, Brijesh; Santhoshi, P. Madhuri; Reddy, P. Venugopal; B, Putra Kumar; Ramachandra, R.K.

doi:10.1016/j.optmat.2020.110162

Cited by 16 publications

(4 citation statements)

References 24 publications

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“…After revolving for 4 min at 25 RPM, the tablets freed from the dust and weighed as Final weight. 18 The friability is calculated by using.…”

Section: Friabilitymentioning

confidence: 99%

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Application of Novel Natural Sweetening Agent-Stevia in Formulation, Evaluation of Nicardipine Hydrochloride Orodispersable Tablets for Rapid Absorption

Dasari,

Phani Kumar,

Gummadi

et al. 2024

Ind. J. Pharm. Edu. Res

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Objectives:The objective of this study was to develop a stable and effective form of an Orodispersible tablet containing Nicardipine Hydrochloride for the immediate treatment of high blood pressure and angina. The aim was to achieve this by using the natural sweetener stevia to improve taste. Background: Nicardipine Hydrochloride is used to treat high blood pressure and angina. However, currently available immediate release forms have limitations in terms of drug release and taste. Therefore, the goal was to develop an Orodispersible form of the drug that would enhance drug release and improve taste masking capabilities. Materials and Methods: We developed formulations of Nicardipine Hydrochloride Orodispersible tablets using the natural sweetener Stevia rebaudiana to enhance taste and reduce the caustic sensation. We confirmed the compatibility of the drug-excipient mixture using FTIR. Drug content and dissolution were determined through UV spectrophotometry. We also conducted organoleptic tests and other compendial specification tests. Precompression parameters were evaluated, and measures were taken to improve the flow behavior of the formulation blend by using excipients with excellent flow properties. Based on disintegration and dissolution time, we selected the F6 formulation as the optimized formula. We then subjected the developed trial to stability studies for three months, evaluating disintegration time, drug content, and dissolution. Results: The optimized formulation demonstrated a disintegration time of 46.25±0.85 sec and a dissolution rate of 100.50±2.50. Compendial tests remained stable without any significant fluctuations after the stability study. Also, the taste of the drug was pleasant after taste. Conclusion: Through the appropriate selection of excipients, we successfully developed a stable and effective form of Nicardipine Hydrochloride Orodispersible tablet with enhanced drug release (using the solid dispersion technique) and improved taste masking capabilities. The optimized formulation yielded favorable results in terms of disintegration and dissolution time, drug content, and stability.

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“…After revolving for 4 min at 25 RPM, the tablets freed from the dust and weighed as Final weight. 18 The friability is calculated by using.…”

Section: Friabilitymentioning

confidence: 99%

“…Through wicking action, water transports from petri dish to tissue paper and then to tablet the time is measured as wetting time. 18 The wetted tablet was then measured. Water absorption ratio, R, was determined using the…”

Section: Wetting Time and Water Absorption Ratiomentioning

confidence: 99%

Application of Novel Natural Sweetening Agent-Stevia in Formulation, Evaluation of Nicardipine Hydrochloride Orodispersable Tablets for Rapid Absorption

Dasari,

Phani Kumar,

Gummadi

et al. 2024

Ind. J. Pharm. Edu. Res

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“…Recently, Shaik et al [70] synthesized LaAlO 3 : Bi 3+ , Tb 3+ nanoparticles (LNP), and then these were surface modified with chitosan (CS) for targeted drug delivery and bioimaging of breast cancer cells. These authors used capecitabine (CAP) as a model drug to assess the drug delivery ability of LNP.…”

Section: Figure 15mentioning

confidence: 99%

Progress and Recent Strategies in the Synthesis and Catalytic Applications of Perovskites Based on Lanthanum and Aluminum

2022

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Lanthanum aluminate-based perovskite (LaAlO3) has excellent stability at high temperatures, low toxicity, and high chemical resistance and also offers wide versatility to the substitution of La3+ and Al3+, thus, allowing it to be applied as a catalyst, nano-adsorbent, sensor, and microwave dielectric resonator, amongst other equally important uses. As such, LaAlO3 perovskites have gained importance in recent years. This review considers the extensive literature of the past 10 years on the synthesis and catalytic applications of perovskites based on lanthanum and aluminum (LaAlO3). The aim is, first, to provide an overview of the structure, properties, and classification of perovskites. Secondly, the most recent advances in synthetic methods, such as solid-state methods, solution-mediated methods (co-precipitation, sol–gel, and Pechini synthesis), thermal treatments (combustion, microwave, and freeze drying), and hydrothermal and solvothermal methods, are also discussed. The most recent energetic catalytic applications (the dry and steam reforming of methane; steam reforming of toluene, glycerol, and ethanol; and oxidative coupling of methane, amongst others) using these functional materials are also addressed. Finally, the synthetic challenges, advantages, and limitations associated with the preparation methods and catalytic applications are discussed.

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“…Due to its strong optoelectronic capabilities, the B site held by Al 3+ can be replaced by transition metal ions to produce a variety of applications, including photodetector [13,14] and luminescent phosphor [15,16], which have been reported in numerous papers. Furthermore, due to its distinctively extended fluorescence lifespan and significant Stokes shift, LaAlO 3 is widely used in the field of luminous materials [17][18][19][20]. In addition, numerous researchers have reported on its additional characteristics, such as poor heat conductivity [21,22].…”

Section: Introductionmentioning

confidence: 99%

Optimizing the Structure and Optical Properties of Lanthanum Aluminate Perovskite through Nb5+ Doping

Liu,

Zou,

Chen

et al. 2024

Nanomaterials

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This work involves the introduction of niobium oxide into lanthanum aluminate (LaAlO3) via a conventional solid-state reaction technique to yield LaAlO3:Nb (LaNbxAl1−xO3+δ) samples with Nb5+ doping levels ranging from 0.00 to 0.25 mol%. This study presents a comprehensive investigation of the effects of niobium doping on the phase evolution, defect control, and reflectance of LaNbxAl1−xO3+δ powder. Powder X-ray diffraction (XRD) analysis confirms the perovskite structure in all powders, and XRD and transmission electron microscopy (TEM) reveal successful doping of Nb5+ into LaNbxAl1−xO3+δ. The surface morphology was analyzed by scanning electron microscopy (SEM), and the results show that increasing the doping concentration of niobium leads to fewer microstructural defects. Oxygen vacancy defects in different compositions are analyzed at 300 K, and as the doping level increases, a clear trend of defect reduction is observed. Notably, LaNbxAl1−xO3+δ with 0.15 mol% Nb5+ exhibits excellent reflectance properties, with a maximum infrared reflectance of 99.7%. This study shows that LaNbxAl1−xO3+δ powder materials have wide application potential in the field of high reflectivity coating materials due to their extremely low microstructural defects and oxygen vacancy defects.

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Optical emissions of chitosan modified LaAlO3: Bi3+, Tb3+ nanoparticles for bio labeling and drug delivery to breast cancer cells

Cited by 16 publications

References 24 publications

Application of Novel Natural Sweetening Agent-Stevia in Formulation, Evaluation of Nicardipine Hydrochloride Orodispersable Tablets for Rapid Absorption

Application of Novel Natural Sweetening Agent-Stevia in Formulation, Evaluation of Nicardipine Hydrochloride Orodispersable Tablets for Rapid Absorption

Progress and Recent Strategies in the Synthesis and Catalytic Applications of Perovskites Based on Lanthanum and Aluminum

Optimizing the Structure and Optical Properties of Lanthanum Aluminate Perovskite through Nb5+ Doping

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