Optical detection of pH changes in artificial sweat using near-infrared fluorescent nanomaterials

Sultana, Nigar; Dewey, Hannah; Budhathoki-Uprety, Januka

doi:10.1039/d2sd00110a

Cited by 10 publications

(15 citation statements)

References 54 publications

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“…In the acidic sweat solution, the photoluminescence from SC-SWCNTs was noisy and difficult to interpret, and hence, data was not included. Previous studies show that SC-SWCNTs’ fluorescence quenches in an acidic solution . Thus, CHAPS as a surface coating on nanotubes provides an advantage as compared to SC coatings.…”

Section: Resultsmentioning

confidence: 99%

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Carbon Nanotubes for Optical Detection of Quaternary Ammonium Compounds in Complex Media

Dewey,

Jones,

Lucas

et al. 2023

ACS Appl. Nano Mater.

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Quaternary ammonium compounds (QACs) are widely used in disinfectants, cleaners, preservatives, cosmetics, and agriculture. Recently, QACs have been detected in the human bloodstream, breast milk, and neonatal mouse brain, which shows that these compounds can cross biological barriers. In vivo studies showed that chronic low-level exposure to QACs causes developmental, reproductive, and immune dysfunctions, whereas in vitro studies indicate that QACs can affect reproductive systems, disrupt cholesterol biosynthesis, increase inflammatory cytokines, and decrease mitochondrial functions. Effects of QACs on health are gradually emerging, amid increased use of QAC disinfectants during the COVID-19 pandemic. Analysis of biological fluids including blood, urine, sweat, and saliva can provide vital information in determining the biological effects of analytes. Biofluid analysis is convenient yet crucial because of non-invasive/or minimally invasive procedures that can be performed outside hospital settings. Interest in optical detection methods for biofluid analysis has been growing due to recent advances in detection technologies and availability of tunable materials to aid the technologies. Detection in the near-infrared (NIR) spectral range is advantageous over the visible range mainly due to minimal autofluorescence, light-scattering, and absorption from native biological molecules in the NIR range. Photoluminescent single-walled carbon nanotubes (SWCNTs) are promising candidates for the development of NIR optical probes and sensors due to their non-photobleaching NIR fluorescence, tunable surface chemistry, and high sensitivity. Herein, we report optical detection of QACs in protein-rich media and a model biofluid. We functionalized photoluminescent SWCNTs with bile salt derivatives that enabled the detection of QACs in artificial sweat and serum-protein-enriched media. The QAC detection was significant at nanomolar concentrations, which is within the threshold that can affect various physiological processes. Thus, nanotube-based optical detection could be well suited for the analysis of QACs in biological fluids.

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Section: Resultsmentioning

confidence: 99%

“…Previous studies show that SC-SWCNTs' fluorescence quenches in an acidic solution. 44 Thus, CHAPS as a surface coating on nanotubes provides an advantage as compared to SC coatings. Detection of BACs in Protein-Rich Media.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Carbon Nanotubes for Optical Detection of Quaternary Ammonium Compounds in Complex Media

Dewey,

Jones,

Lucas

et al. 2023

ACS Appl. Nano Mater.

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“…This can assume that the interfacial interactions, surface charge densities, and proximity of the nanotubes to solvent molecules resulting in differences in dielectric environment could cause a change in optical response. Sultana and Budhathoki-Uprety et al 23 developed optical probes using SWCNTs to detect changes in pH in both aqueous media and artificial sweat. The study showcases the carbon nanotube sensors' capacity to accurately identify pH fluctuations within a biologically significant region by detecting alterations in near-infrared emission.…”

Section: Chirality-sorted/monochiral Swcntsmentioning

confidence: 99%

“…Fluorescence techniques employing common visible fluorophores frequently suffer from strong scattering, absorption, and autofluorescence, limiting penetration depth, low signal-to-noise ratios, and phototoxicity. , Therefore, with NIR emission, SWCNTs have an advantage in optical sensing and imaging. Photoluminescence of SWCNTs is extremely sensitive to changes in the surface environment, which is the basis for molecular recognition. , Furthermore, SWCNTs’ unique properties like their size and high surface area, and biocompatibility upon functionalization can enhance sensing performance in biosensor platforms . Thus, SWCNTs are considered to be valuable materials for developing optical sensors.…”

Section: Introductionmentioning

confidence: 99%

Understanding the Molecular Assemblies of Single Walled Carbon Nanotubes and Tailoring their Photoluminescence for the Next-Generation Optical Nanosensors

Sultana,

Dewey,

Arellano

et al. 2024

Chem. Mater.

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Interest in optical materials for biomedical imaging and sensing applications has grown significantly in recent decades. Among a variety of material choices, single-walled carbon nanotubes (SWCNTs) are emerging materials for molecular imaging, sensing, and optoelectronic applications due to their nonphotobleaching photoluminescence in the tissue-transparent near-infrared spectral window. However, pristine SWCNTs need surface functionalization to render them soluble in biofriendly media and facilitate their interaction with target analytes. Understanding the functionalization of SWCNTs and the structures of their resulting molecular assemblies plays a pivotal role in yielding efficient optical probes and sensors. Studies have shown that the size, composition, configuration, and concentration of functionalizing compounds on the nanotube surface can affect the nanotube dispersions and optical characteristics. Herein, we review recent progress in the design, synthesis, and applications of SWCNT-based optical nanosensors. An overview of nanotube structure, functionalization, suspension of SWCNTs in solutions with various dispersants, and their molecular assemblies presented from molecular dynamics simulation studies is provided. We further discuss how these assemblies along with solvent dielectric affect nanotube dispersion efficiencies, their role in a nanotube's optical response to a change in its local environment, and how a nanotube's optical properties are utilized for sensor development.

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“…[20,21] Chemically crosslinked MXene/ superaligned carbon nanotube (CNT) composite films exhibit a mass production capability, showing the high potential for practical application to prepare efficient EMI shields. [22,23] MXene sediment-based hydrogels show sensitive and reliable detections of human motions and smart coding as wearable, flexible devices. [24,25] Therefore, it is essential to improve the flexibility and stability of MXene as it is easily oxidized in the environment.…”

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confidence: 99%

Recent Advancements of MXene/Nanocellulose‐Based Hydrogel and Aerogel: A Review

Ahmed,

Hossain,

Al Parvez

et al. 2023

Adv Energy and Sustain Res

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MXenes have been highly attractive to researchers owing to their layered nanostructure, excellent electrical conductivity, and abundance of functional groups. Meanwhile, nanocellulose materials, known for their biodegradability, renewability, compatibility with living organisms, and cost‐effectiveness, have emerged as a popular choice for material selection researchers. Recent research has discovered that combining nanocellulose with MXenes can improve the mechanical properties of MXenes, resulting in composite materials with remarkable electrical and mechanical properties. This article provides an overview of the three main types of nanocellulose: cellulose nanofiber, cellulose nanocrystal, and bacterial cellulose. It also discusses various synthesis methods for MXenes, including MXene/nanocellulose‐based hydrogel and aerogel. Additionally, the article highlights the multiple uses of MXene/nanocellulose composites in different fields, including flexible sensing materials, electromagnetic shielding, energy storage structures, and wearable health monitoring. This review covers distinctive characteristics and unique MXene/nanocellulose composite behaviors, their recent advancements in MXene/nanocellulose synthesis, and applications. Moving forward, the potential for these materials to be used innovatively with anticipation of taking the MXene/nanocellulose‐based research further steps across the respective scientific community.

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Optical detection of pH changes in artificial sweat using near-infrared fluorescent nanomaterials

Abstract: Photoluminescent single-walled carbon nanotubes are versatile tools for the development of optical nanosensors. Carbon nanotubes were employed for the optical detection of pH within a biologically relevant range in a model biofluid.

Cited by 10 publications

References 54 publications

Carbon Nanotubes for Optical Detection of Quaternary Ammonium Compounds in Complex Media

Carbon Nanotubes for Optical Detection of Quaternary Ammonium Compounds in Complex Media

Understanding the Molecular Assemblies of Single Walled Carbon Nanotubes and Tailoring their Photoluminescence for the Next-Generation Optical Nanosensors

Recent Advancements of MXene/Nanocellulose‐Based Hydrogel and Aerogel: A Review

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