Optical detection for droplet size control in microfluidic droplet-based analysis systems

Nguyen, Nam‐Trung; Lassemono, Sumantri; Chollet, Franck

doi:10.1016/j.snb.2005.12.010

Cited by 99 publications

(77 citation statements)

References 7 publications

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“…Hence, real time detection of droplets is critical for accurate control. Up to now, optical detection methods are the most widely used, 14,15 e.g., using either photodiode for simple counting or high speed charge-coupled device ͑CCD͒ camera with image processing for detection of more detailed characteristics.…”

Section: Introductionmentioning

confidence: 99%

Real-time detection, control, and sorting of microfluidic droplets

Niu

Zhang²,

Peng³

et al. 2007

Biomicrofluidics

136

117

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We report the design and implementation of capacitive detection and control of microfluidic droplets in microfluidic devices. Integrated microfluidic chip͑s͒ with detection/control circuit enables us to monitor in situ the individual volume of droplets, ranging from nanoliter to picoliter, velocity and even composition, with an operation frequency of several kilohertz. Through electronic feedback, we are able to easily count, sort, and direct the microfluidic droplets. Potential applications of this approach can be employed in the areas of biomicrofluidic processing, microchemical reactions as well as digital microfluidics.

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Section: Introductionmentioning

confidence: 99%

Real-time detection, control, and sorting of microfluidic droplets

Niu

Zhang²,

Peng³

et al. 2007

Biomicrofluidics

136

117

View full text Add to dashboard Cite

show abstract

“…Our approach is based on time series extraction and analysis representing a powerful tool to provide automatic analysis in LOC for pointwise flow information. As it was demonstrated also in Nguyen et al (2006), where droplets size, frequency and shape were efficiently detected in a microfluidic two-phase system by means of optical detection of the out-coming light intensity.…”

Section: Introductionmentioning

confidence: 72%

A polymeric micro-optical system for the spatial monitoring in two-phase microfluidics

Sapuppo

Schembri

Fortuna

et al. 2011

Microfluid Nanofluid

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This article presents a polymeric micro-optical system that consists of two coupled miniaturized devices for spatially distributed characterization of microfluidic two-phase phenomena exploiting multiwavelength optical signals. The input device implements four optical windows (slits) which are superimposed on the centerline of a microfluidic serpentine channel and illuminate specific locations of the microchannel. The flow-related information is then collected by an ad hoc polymeric micro-optical output device that guides and merges the spatially distributed information into a single output signal, which maintains memory of the spatial coordinates by using the wavelengths as fingerprints of the slits' position in the microfluidic channel. Both micro-optical devices were designed, simulated, and characterized in static and dynamic conditions. Experiments on two-phase (air and ethanol) flow were carried out by applying constant and periodic flow rate functions. In both cases, the system was proved to be efficient in capturing the spatial-temporal dynamics of flow profiles.

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“…While impedance based detection can be readily integrated into planar chip configurations using planar electrodes [4] integration strategies for optofluidics have not been fully developed [5]. A popular approach is to insert optical fibres into microchannels aligned with the microfluidics [6][7][8]. While this exploits the low cost and well characterised performance of commercial fibres, the insertion of the fibres is a manual process which is not suited to mass production.…”

Section: Introductionmentioning

confidence: 99%

Integrated optical waveguides and inertial focussing microfluidics in silica for microflow cytometry applications

Butement

Hunt²,

Rowe

et al. 2016

J. Micromech. Microeng.

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A key challenge in the development of a microflow cytometry platform is the integration of the optical components with the fluidics as this requires compatible micro-optical and microfluidic technologies. In this work a microflow cytometry platform is presented comprising monolithically integrated waveguides and deep microfluidics in a rugged silica chip. Integrated waveguides are used to deliver excitation light to an etched microfluidic channel and also collect transmitted light. The fluidics are designed to employ inertial focussing, a particle positioning technique, to reduce signal variation by bringing the flowing particles onto the same plane as the excitation light beam. A fabrication process is described which exploits microelectronics mass production techniques including: sputtering, ICP etching and PECVD. Example devices were fabricated and the effectiveness of inertial focussing of 5.6 µm fluorescent beads was studied showing lateral and vertical confinement of flowing beads within the microfluidic channel. The fluorescence signals from flowing calibration beads were quantified demonstrating a CV of 26%. Finally the potential of this type of device for measuring the variation in optical transmission from input to output waveguide as beads flowed through the beam was evaluated.

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Optical detection for droplet size control in microfluidic droplet-based analysis systems

Cited by 99 publications

References 7 publications

Real-time detection, control, and sorting of microfluidic droplets

Real-time detection, control, and sorting of microfluidic droplets

A polymeric micro-optical system for the spatial monitoring in two-phase microfluidics

Integrated optical waveguides and inertial focussing microfluidics in silica for microflow cytometry applications

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