Optical Core-Shell Model for Nano-Delivery Applications

Abstract

Abstract. In this paper, we will analyze the application of nanomaterials in biomedicine, that is to say, we will present the recent accomplishments in basic and clinical nanomedicine. Achieving the full potential of nanomedicine may be years or even decades away; however, potential advances in drug delivery, diagnosis, and the development of nanotechnology-related drugs are starting to change the landscape of medicine. Site-specific targeted drug delivery (made possible by the availability of unique delivery platforms, such as dendrimers, nanoparticles and nanoliposomes) and personalized medicine (result of the advance in pharmacogenetics) are just a few concepts on the horizon of research. In this paper, we have especially analyzed the changes in basic physical properties of sphericalshaped nanoparticles that can be made in several (nano)layers and have, at the same time, multiple applications in medicine. The subject of the research in this paper includes the modeling of nanomaterials in the field of pharmaceutical technology for biomedical application. This includes a very precise encapsulated drug delivery on the exactly defined place in the human tissue or organ and the disintegration of the capsule -drug carrier, so that the medicament can start producing its effect. The goal of multidisciplinary researches with biocompatible molecular nanomaterials is to find the parameters and the possibilities to construct boundary surfaces that will, in interaction with the biological environment, create such properties of nanolayers that can be conveniently used for layers of drug carrier capsules, biochips and biomarkers. These layers should demonstrate a controlled disintegration of structure, better dielectric properties, discrete luminescence and appropriate bioporosity, as all of these are the requirements of contemporary nanomedicine.

Optical Specificity of Thin Shell for Nano-Delivery Model

“…As reported earlier [1,2], our research group believes that the methodology used to analyze optical properties of nano-films can be used for theoretical studies of materials that are typical for drug carriers in nano-pharmacy. We are primarily thinking of core shell models under which the systems include a spherical shape.…”

“…As we reported on last RAD conferences [1,2] the development of biomedical science is directly related to the development of natural and mathematical sciences, especially materials science. Enormous resources are invested in the research that will lead to the solutions for many deadly diseases and in the end it is impossible not to put a completely logical question: whether the results of modern research justify the invested resources [3,4]?…”

“…Numerous novel nanomedicine-related applications are under development or are in a research phase, and the process of converting basic research in nanomedicine into commercially viable products will be long and difficult. Achieving the full potential of nanomedicine may be years or even decades away, however, potential advances in drug delivery, diagnosis, and development of nanotechnology-related drugs are starting to change the landscape of medicine [1][2][3][4]. Site-specific targeted drug delivery (made possible by the availability of unique delivery platforms, such as dendrimers, nanoparticles and nanoliposomes) [5][6][7] and personalized medicine (result of the advance in pharmacogenetics) [8][9][10] are just a few concepts on the horizon of research.…”