Optical coherence tomography using tissue clearing for skin disease diagnosis

Assessment of Optical Coherence Tomography Imaging in the Diagnosis of Non-Melanoma Skin Cancer and Benign Lesions Versus Normal Skin

“…We demonstrated a characteristic OCT morphology of AK, BCC, and normal adjacent skin in accordance with other studies, 6,10,11,14,20,26–28 and we discovered the OCT morphology matches well‐known histopathology of NMSC. When OCT images from the same lesions were compared, they looked similar, in concordance with the high reproducibility of OCT images demonstrated in earlier studies of epidermis and nail thickness measurements 20,29,30 …”

“…Studies of new diagnostic tests and technologies should be performed following the internationally recognized set of guidelines called Standards for Reporting of Diagnostic Accuracy published in 2003 12 . Only a few formal diagnostic studies have been conducted in the field of OCT imaging of NMSC; 9,13,14 and more are required to establish the accuracy and clinical usefulness of OCT in NMSC diagnosis.…”

The first experience of using high-frequency ultrasound examination to diagnose the depth-of-skin damage in combination with the use of OCT

“…Visualization of the vessels of the microcirculatory bed in the area of the superficial plexuses was preserved, while deeper vessels were visualized due to edema worse than in healthy skin. The lowsignal zones characterizing vessels of this level in the area of damage were characterized by less clear boundaries due to perivascular edema and were larger than in images of healthy skin due to inflammatory dilation [4].…”

“…Hair follicles and sebaceous glands with signs of inflammatory edema in the form of clustershaped light areas, with the inclusion of darker areas, were visualized in almost all images with a grade 1 burn [4].…”

“…At the same time, the vessels of the superficial plexuses, probably due to severe edema, were practically not visualized, but more deeply located large dilated skin vessels were visualized. Individual sebaceous-hair complexes with signs of severe inflammation, impairing their visualization, continued to be visualized [4].…”