Optical Coherence Tomography to Identify Intramucosal Carcinoma and High-Grade Dysplasia in Barrett’s Esophagus

Evans, John A.; Poneros, John M.; Bouma, Brett E.; Bressner, Jason; Halpern, Elkan F.; Shishkov, Milen; Lauwers, Gregory Y.; Mino‐Kenudson, Mari; Nishioka, Norman S.; Tearney, Guillermo J.

doi:10.1016/s1542-3565(05)00746-9

Cited by 243 publications

(187 citation statements)

References 29 publications

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“…The overall average accuracy achieved by the readers was 82.6% (range, 73.7-94.7%), with good sensitivity (80.3-85.7%) and specificity (83.3-97.6%) for each of the carcinoma types over the two validation assessments. The sensitivities and specificities achieved in this study are comparable to those reported in prior studies validating OCT criteria in esophageal (23,24) and cardiovascular pathology (19).…”

Section: Discussionsupporting

confidence: 84%

“…OCT can be used to conduct large-volume in vivo microscopy of tissue with resolutions comparable to low-power microscopy (18). OCT has been used to accurately detect and diagnose pathology in vivo for a number of years (17)(18)(19)(20)(21)(22)(23)(24) and has been used to assess the fine microarchitectural features in both normal and pathologic lung (25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43).…”

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confidence: 99%

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Diagnosing Lung Carcinomas with Optical Coherence Tomography

et al. 2015

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Rationale: Lung carcinoma diagnosis on tissue biopsy can be challenging because of insufficient tumor and lack of architectural information. Optical coherence tomography (OCT) is a high-resolution imaging modality that visualizes tissue microarchitecture in volumes orders of magnitude larger than biopsy. It has been proposed that OCT could potentially replace tissue biopsy.Objectives: We aim to determine whether OCT could replace histology in diagnosing lung carcinomas. We develop and validate OCT interpretation criteria for common primary lung carcinomas: adenocarcinoma, squamous cell carcinoma (SCC), and poorly differentiated carcinoma.Methods: A total of 82 ex vivo tumor samples were included in a blinded assessment with 3 independent readers. Readers were trained on the OCT criteria, and applied these criteria to diagnose adenocarcinoma, SCC, or poorly differentiated carcinoma in an OCT validation dataset. After a 7-month period, the readers repeated the training and validation dataset interpretation. An independent pathologist reviewed corresponding histology. Measurements and Main Results:The average accuracy achieved by the readers was 82.6% (range, 73.7-94.7%). The sensitivity and specificity for adenocarcinoma were 80.3% (65.7-91.4%) and 88.6% (80.5-97.6%), respectively. The sensitivity and specificity for SCC were 83.3% (70.0-100.0%) and 87.0% (75.0-96.5%), respectively. The sensitivity and specificity for poorly differentiated carcinoma were 85.7% (81.0-95.2%) and 97.6% (92.9-100.0%), respectively. Conclusions:Although these results are encouraging, they indicate that OCT cannot replace histology in the diagnosis of lung carcinomas. However, OCT has potential to aid in diagnosing lung carcinomas as a complement to tissue biopsy, particularly when insufficient tissue is available for pathology assessment.

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Section: Discussionsupporting

confidence: 84%

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confidence: 99%

Diagnosing Lung Carcinomas with Optical Coherence Tomography

et al. 2015

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“…2 In addition, it has been developed for application in cardiovascular, gastroesophageal, and cancer imaging. 3 OCT has also found application beyond the medical field, in areas such as metrology, non-destructive testing, microfluidics, and others. 4 As in other 3-D optical imaging modalities, OCT suffers from reduced depth-of-field when increasing the numerical aperture (NA) of the imaging system.…”

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confidence: 99%

Polarization-sensitive interferometric synthetic aperture microscopy

South

Liu

et al. 2015

Applied Physics Letters

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Three-dimensional optical microscopy suffers from the well-known compromise between transverse resolution and depth-of-field. This is true for both structural imaging methods and their functional extensions. Interferometric synthetic aperture microscopy (ISAM) is a solution to the 3D coherent microscopy inverse problem that provides depth-independent transverse resolution. We demonstrate the extension of ISAM to polarization sensitive imaging, termed polarization-sensitive interferometric synthetic aperture microscopy (PS-ISAM). This technique is the first functionalization of the ISAM method and provides improved depth-of-field for polarization-sensitive imaging. The basic assumptions of polarization-sensitive imaging are explored, and refocusing of birefringent structures is experimentally demonstrated. PS-ISAM enables high-resolution volumetric imaging of birefringent materials and tissue.

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“…OCT is promising in many fields of cancer diagnosis, especially where excisional biopsy or another invasive method is typically used but undesirable [223]. OCT is endoscope-compatible [41] and thus well suited to examine hollow organs like the gastrointestinal tract [224][225][226], the bronchi [227] and the urinary bladder [228]. Subcutaneous imaging needles [42,229,230] and forward imaging probes [231][232][233] provide further possibilities to apply OCT for minimally invasive examination.…”

Section: Emerging Medical Applicationsmentioning

confidence: 99%

Optical coherence tomography—current technology and applications in clinical and biomedical research

et al. 2011

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Optical coherence tomography (OCT) is a non-invasive imaging technique providing real-time twoand three-dimensional images of scattering samples with micrometer resolution. Mapping the local reflectivity, OCT visualizes the morphology of the sample. In addition, functional properties such as birefringence, motion or the distribution of certain substances can be detected with high spatial resolution. The main field of application is bio-medical imaging and diagnostics. In ophthalmology, OCT is accepted as a clinical standard for diagnosing and monitoring treatment of a number of retinal diseases, and OCT is becoming an important instrument for clinical cardiology. New applications are emerging in various medical fields, e. g. early-stage cancer detection, surgical guidance, and early diagnosis of musculoskeletal diseases. OCT has also proven its value as a tool for developmental biology. The number of companies involved in manufacturing OCT systems has increased substantially during the last years-especially due to its success in opthalmology-and this technology can be expected to continue to spread into various fields of application.

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Optical Coherence Tomography to Identify Intramucosal Carcinoma and High-Grade Dysplasia in Barrett’s Esophagus

Cited by 243 publications

References 29 publications

Diagnosing Lung Carcinomas with Optical Coherence Tomography

Diagnosing Lung Carcinomas with Optical Coherence Tomography

Polarization-sensitive interferometric synthetic aperture microscopy

Optical coherence tomography—current technology and applications in clinical and biomedical research

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