Optical coherence tomography parameters in patients with photosensitive juvenile myoclonic epilepsy

Gömceli, Yasemin Bıçer; Doğan, Berna; Genç, Fatma; Uygur, Elif; Çoban, Deniz; Erdal, Abidin; Erol, Muhammed Kazım

doi:10.1016/j.seizure.2015.12.014

Cited by 18 publications

(21 citation statements)

References 31 publications

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“…This assumption is supported by other papers pointing to the hyperexcitability of the visual cortex as a primary generator of the PS [18,19]. Structural data also sheds light on the potential facility of the PPR to propagate from the occipital to fronto-polar regions [3,4] and between other areas including interhemispheric pathways [20,21].…”

Section: Methodology and Limitationssupporting

confidence: 73%

Symmetry and interhemispheric propagation of paediatric photoparoxysmal response

Skadorwa

Strzelecka

2020

Neurol Neurochir Pol.

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Aim of the study. To investigate the speculated interhemispheric symmetry and the pattern of propagation of paediatric photoparoxysmal response.Clinical rationale for the study. Quantitative analysis of the photoparoxysmal response (PPR) to intermittent photic stimulation is a promising method of assessing photosensitivity (PS). The pattern of PPR propagation underlies the model used for calculations. The generalisation of a discharge should correspond with the parameters objectively characterising the PPR in both cerebral hemispheres. However, to date no evidence of a postulated symmetry has been demonstrated. Materials and methods. Our analysis was performed by comparing the EEG amplitude and interhemispheric coherence (ICoh) in both hemispheres in 100 non-epileptic individuals of both sexes, aged 5-18 years, with PS grade IV (the PPR group) and without PS (the control group). The amplitude and ICoh values were recorded and analysed statistically.Results. The distribution of amplitude values between the hemispheres was comparable in both groups, but was significantly different between the PPR group and the control group. Individual tracks of propagation revealed hemispheric symmetry. Interhemispheric coherence values were significantly higher in occipital, temporal and fronto-polar areas in children with PS. Conclusions and clinical implications.This study provides objective evidence of interhemispheric symmetry in paediatric PPR, which supports the link with generalised seizures. Interhemispheric propagation is facilitated in children with PS, and propagation is more likely in the occipital and temporal regions.

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Section: Methodology and Limitationssupporting

confidence: 73%

Symmetry and interhemispheric propagation of paediatric photoparoxysmal response

Skadorwa

Strzelecka

2020

Neurol Neurochir Pol.

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“…In addition, Anyanwu and Ehiri's study showed that ocular anomalies may be detected in patients with photosensitive epilepsy and that these abnormalities may affect visual acuity (Anyanwu and Ehiri, 2004). In the study conducted by Gomceli et al (2016) on JME patients, the thickness of the peripapillary retinal nerve fibre layer of the superior quadrants for both eyes and choroid layer of the left eye was significantly greater, while the macular layer was significantly thinner in patients with photosensitivity compared to patients without photosensitivity. The choroidal layer provides metabolic support to the retina in the eye and is a vascular structure that provides blood flow to the external retinal layer.…”

Section: Discussionmentioning

confidence: 96%

“…The choroidal layer provides metabolic support to the retina in the eye and is a vascular structure that provides blood flow to the external retinal layer. The changes in choroidal thickness and resulting metabolism and vascularisation may be related to photosensitivity, and these microstructural differences in the optic nerve may be the cause or the symptom of photosensitivity (Gomceli et al, 2016). In this study, we investigated the relationship between photosensitivity and colour vision in JME patients in order to shed light on the pathophysiology of photosensitivity, which still remains unclear.…”

Section: Discussionmentioning

confidence: 99%

Colour vision in juvenile myoclonic epilepsy

Kucukseymen

Genç²,

Doğan

et al. 2019

Epileptic Disorders

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Aims . To determine the integrity of colour perception, related to photic sensitivity, in patients with juvenile myoclonic epilepsy. Methods . Twenty‐four patients with photoparoxysmal response, 27 patients without photoparoxysmal response, and 32 healthy individuals were investigated using the Farnsworth Munsell‐100 Hue test to calculate error scores for total colour, blue/yellow, and red/green. Results . No significant differences were observed regarding blue/yellow, red/green or total error score between juvenile myoclonic epilepsy patients with or without photoparoxysmal response. However, the data for all three scores were significantly higher in both patient groups compared to the healthy control group. In both patient groups, the blue/yellow error score was significantly higher than the red/green error score. Conclusions . We were unable to identify a relationship between photoparoxysmal response and colour vision in patients with juvenile myoclonic epilepsy. We believe that the underlying reason why juvenile myoclonic epilepsy patients had significantly higher blue/yellow, red/green, and total error score compared to the healthy control group may be due to GABA dysfunction, which is considered to play a role in the pathophysiology of this disease as well as the physiology of colour vision.

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“…However, RNFL thinning has been documented in patients suffering from epilepsy. Factors which may influence RNFL thinning include duration of epilepsy, drug resistance and intellectual disability [22,23].…”

Section: Discussionmentioning

confidence: 99%

Study of Visual Function in Adult Epileptic Patients on Sodium Valproate or Carbamazepine Monotherapy

Matthew¹,

Tharakan²,

Tai³

et al. 2019

Cureus

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Objective Epilepsy is a debilitating disease. Visual function changes have been reported and may be attributed to the epileptic changes or as a result of medication side effect. Sodium valproate and carbamazepine are both first line anti-epileptic medications used in Malaysian health care. Sodium valproate inhibits glutamate and γ-aminobutyric acid (GABA) transaminase while carbamazepine acts on the sodium channel - both are an important part of the retina. This study aimed to compare the visual functions of epilepsy patients on carbamazepine or sodium valproate monotherapy. Design A cross-sectional study was conducted at a tertiary hospital between June 2016 and November 2018. Methods Patients with idiopathic epilepsy that fulfill the inclusion and exclusion criteria were recruited from the neurology clinic. They were divided into two groups and underwent complete eye examinations. Visual functions such as color vision testing, contrast sensitivity, visual field and retinal nerve fiber layer measurement were subsequently performed. Statistical analysis was done using Statistical Package for the Social Science, version 24 (SPSS Inc, Chicago, IL, USA). Results A total of 100 patients (sodium valproate: 50 patients; carbamazepine: 50 patients) were recruited for the study. There were no statistically significant changes in anatomical or visual function between the sodium valproate and carbamazepine group. However, patients from both groups displayed color vision defect in the blue and green axes. Changes in color vision could indicate early retina toxicity secondary to the medication. Although there were no visual field changes, patients recorded a slight reduction of mean deviation. Changes of mean deviation could be attributed to the side effect of medication or the disease process. Conclusions Epileptic patients taking sodium valproate or carbamazepine did not demonstrate statistically significant change in visual function.

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Optical coherence tomography parameters in patients with photosensitive juvenile myoclonic epilepsy

Abstract: This is the first study to our knowledge which has investigated the relation between the OCT parameters and photosensitivity in patients with JME. We concluded that these microstructural features may be related to photosensitivity in patients with JME.

Cited by 18 publications

References 31 publications

Symmetry and interhemispheric propagation of paediatric photoparoxysmal response

Symmetry and interhemispheric propagation of paediatric photoparoxysmal response

Colour vision in juvenile myoclonic epilepsy

Study of Visual Function in Adult Epileptic Patients on Sodium Valproate or Carbamazepine Monotherapy

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