Optical coherence tomography of malignancy in hamster cheek pouches

Matheny, E.; Hanna, Nevine; Jung, Woonggyu; Chen, Zhongping; Wilder‐Smith, Petra; Mina-Araghi, Reza; Brenner, Matthew

doi:10.1117/1.1783897

Cited by 68 publications

(52 citation statements)

References 13 publications

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“…18 In clinical trials, OCT endoscopes have been used in malignancies in different organs, including the gastrointestinal tract, larynx, esophagus, uterine cervix, colon, urinary bladder, and vascular, systems. [18][19][20] In this researches, it is shown that the alteration of intrinsic light scattering properties in tumor tissues make detection possible by OCT imaging, and can promote the clinical application of OCT technique.…”

Section: Discussionmentioning

confidence: 99%

Application of hyperosmotic agent to determine gastric cancer with optical coherence tomography ex vivo in mice

et al. 2009

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Abstract. Noninvasive tumor imaging could lead to the early detection and timely treatment of cancer. Optical coherence tomography ͑OCT͒ has been reported as an ideal diagnostic tool for distinguishing tumor tissues from normal tissues based on structural imaging. In this study, the capability of OCT for functional imaging of normal and tumor tissues based on time-and depth-resolved quantification of the permeability of biomolecules through these tissues is investigated. The orthotopic graft model of gastric cancer in nude mice is used, normal and tumor tissues from the gastric wall are imaged, and a diffusion of 20% aqueous solution of glucose in normal stomach tissues and gastric tumor tissues is monitored and quantified as a function of time and tissue depth by an OCT system. Our results show that the permeability coefficient is ͑0.94± 0.04͒ ϫ 10 −5 cm/ s in stomach tissues and ͑5.32± 0.17͒ ϫ 10 −5 cm/ s in tumor tissues, respectively, and that tumor tissues have a higher permeability coefficient compared to normal tissues in optical coherence tomographic images. From the results, it is found that the accurate and sensitive assessment of the permeability coefficients of normal and tumor tissues offers an effective OCT image method for detection of tumor tissues and clinical diagnosis.

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Section: Discussionmentioning

confidence: 99%

Application of hyperosmotic agent to determine gastric cancer with optical coherence tomography ex vivo in mice

et al. 2009

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“…[19][20][21] Previous studies using OCT have demonstrated the ability to evaluate characteristics of epithelial, subepithelial, and basement membrane structures and show the potential for near histopathological-level resolution and close correlation with histological appearance. [16][17][18][19][20][21][22][23][24][25][26][27][28][29] Two recent studies have reported the successful use of OCT for the early detection and quantification of radiation-and chemotherapy-induced mucositis in the mouse and hamster models. 30,31 In this feasibility study, the ability of OCT to detect and characterize chemotherapy-induced oral mucositis was evaluated in five human subjects.…”

Section: Optical Coherence Tomographymentioning

confidence: 99%

In vivo optical coherence tomography–based scoring of oral mucositis in human subjects: a pilot study

Kawakami-Wong

Hammer‐Wilson

et al. 2007

J. Biomed. Opt.

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Abstract.A preliminary study to assess noninvasive optical coherence tomography ͑OCT͒ for early detection and evaluation of chemotherapy-induced oral mucositis in five patients. In five patients receiving neoadjuvant chemotherapy for primary breast cancer, oral mucositis was assessed clinically, and imaged using noninvasive OCT. Imaging was scored using a novel imaging-based scoring system. Conventional clinical assessment using the Oral Mucositis Assessment Scale was used as the gold standard. Patients were evaluated on days 0, 2, 4, 7, and 11 after commencement of chemotherapy. OCT images were visually examined by one blinded investigator. The following events were identified using OCT: ͑1͒ change in epithelial thickness and subepithelial tissue integrity ͑beginning on day 2͒, ͑2͒ loss of surface keratinized layer continuity ͑beginning on day 4͒, ͑3͒ loss of epithelial integrity ͑beginning on day 4͒. Imaging data gave higher scores compared to clinical scores earlier in treatment, suggesting that the imaging-based diagnostic scoring was more sensitive to early mucositic change than the clinical scoring system. Once mucositis was established, imaging and clinical scores converged. Chemotherapyinduced oral changes were identified prior to their clinical manifestation using OCT, and the proposed scoring system for oral mucositis was validated for the semiquantification of mucositic change.

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“…Raman spectroscopy 97.44-100 77-100 (Li et al 2010;Guze et al 2015) Elastic scattering spectroscopy 72-98 68-75 (Jerjes et al 2004;Sharwani et al 2006b;Green et al 2014) Diffuse reflectance spectroscopy 76-100 76-97 (Mallia et al 2010;Jayanthi et al 2011;Stephen et al 2013) Narrow-band imaging 84.62-96 88.2-100 (Piazza et al 2010;Yang et al 2012b;Yang et al 2013;Shibahara et al 2014;Vu and Farah 2014;Yang et al 2014) Optical coherence tomography 73-100 78-98 (Matheny et al 2004;Wilder-Smith et al 2004;WilderSmith et al 2005;Wilder-Smith et al 2009;Olivo et al 2011;Hamdoon et al 2013;Green et al 2014) Confocal laser endomicroscopy 80 100 (Nathan et al 2014) Confocal reflectance microscopy 73 88 (Olivo et al 2011) Salivary biomarker miRNA-184 n/a n/a (Zahran et al 2015) IL-6 n/a n/a (Sharma et al 2011) oral cancer in 132 patients, and concluded that RB staining seemed promising for the detection of epithelial dysplasia in oral leukoplakia, lichen planus, and leukokeratosis (Du et al 2007). Zhang et al (2013) combined fluorescence spectroscopic techniques with RB staining to detect oral PMDs in an animal model in vivo and reported that the method showed excellent sensitivity.…”

Section: Chemiluminescencementioning

confidence: 99%

Non-Invasive Techniques for Detection and Diagnosis of Oral Potentially Malignant Disorders

Liu

Zhao

Zeng

et al. 2016

Tohoku J. Exp. Med.

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Oral squamous cell carcinoma (OSCC) is the most common oral and maxillofacial malignancy, and its morbidity and mortality rates are still high in most countries. Oral potentially malignant disorders (PMDs) are used to refer to a heterogeneous group of conditions that are characterized by increased risk for malignant transformation to OSCC. Currently identified oral PMDs include leukoplakia, erythroplakia, palatal lesions associated with reverse smoking, oral lichen planus, oral submucous fibrosis, actinic keratosis, and discoid lupus erythematosus. The early detection and diagnosis of these lesions are important for cancer prevention and disease management. In recent years, there has been a growing and persistent demand for new non-invasive, practical diagnostic techniques that might facilitate the early detection of oral PMDs. The non-invasive detection techniques evaluated in this review are divided into four categories: vital staining with a solution that can be used as a mouth rinse or applied onto a suspected area of the mouth, light-based detection systems, optical diagnostic technologies that employ returned optical signals to reflect structural and morphological changes within tissues, and salivary biomarkers. Most of these techniques have shown great potential for screening and monitoring oral PMDs. In this review article, the authors critically assess these non-invasive detection techniques for oral PMDs. We also provide a summary of the sensitivity and specificity of each technique in detecting oral PMDs and oral cancer, as well as their advantages, disadvantages, clinical applications, and indications.

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Optical coherence tomography of malignancy in hamster cheek pouches

Cited by 68 publications

References 13 publications

Application of hyperosmotic agent to determine gastric cancer with optical coherence tomography ex vivo in mice

Application of hyperosmotic agent to determine gastric cancer with optical coherence tomography ex vivo in mice

In vivo optical coherence tomography–based scoring of oral mucositis in human subjects: a pilot study

Non-Invasive Techniques for Detection and Diagnosis of Oral Potentially Malignant Disorders

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