Optical coherence tomography – near infrared spectroscopy system and catheter for intravascular imaging

Abstract

Owing to its superior resolution, intravascular optical coherence tomography (IVOCT) is a promising tool for imaging the microstructure of coronary artery walls. However, IVOCT does not identify chemicals and molecules in the tissue, which is required for a more complete understanding and accurate diagnosis of coronary disease. Here we present a dual-modality imaging system and catheter that uniquely combines IVOCT with diffuse near-infrared spectroscopy (NIRS) in a single dualmodality imaging device for simultaneous acquisition of microstructural and compositional information. As a proof-of-concept demonstration, the device has been used to visualize co-incident microstructural and spectroscopic information obtained from a diseased cadaver human coronary artery. Swanson, "Optical biopsy and imaging using optical coherence tomography," Nat. Med. 1(9), 970-972 (1995). 3. J. G. Fujimoto, "Optical coherence tomography for ultrahigh resolution in vivo imaging," Nat. Biotechnol. 1361-1367 (2003). 4. R. Leitgeb, C. K. Hitzenberger, and A. F. Fercher, "Performance of Fourier domain vs. time domain optical coherence tomography," Opt. Express 11(8), 889-894 (2003). 5. K. Goda, A. Fard, O. Malik, G. Fu, A. Quach, and B. Jalali, "High-throughput optical coherence tomography at 800 nm," Opt. Express 20(18), 19612-19617 (2012 A. Bartlett, M. Rosenberg, and B. E. Bouma, "Three-dimensional coronary artery microscopy by intracoronary optical frequency domain imaging," JACC Cardiovasc. Imaging 1(6), 752-761 (2008). 10. S. Waxman, M. I. Freilich, M. J. Suter, M. Shishkov, S. Bilazarian, R. Virmani, B. E. Bouma, and G. J. Tearney, "A case of lipid core plaque progression and rupture at the edge of a coronary stent: elucidating the mechanisms of drug-eluting stent failure," Circ. Cardiovasc. Interv. 3(2), 193-196 (2010 Opt. Soc. Am. A 4(3), 423-432 (1987 21(11),

Endoscopic optical coherence tomography: technologies and clinical applications [Invited]

“…It is well known that the sensing depth of diffuse reflectance depends on the source-detector separation (approximately 1/2 of the source-detector separation) [94][95][96]. Thus, in order to gain rough depth sensitivity through the reflectance measurement, a double-probe approach can be used where OCT and reflectance share the same probe (and even the same broad band source) while reflectance collection is performed by a second probe [97]. In addition to single-photon fluorescence, two-photon fluorescence imaging at submicron resolution has also been integrated with OCT endoscopy, where a forward-viewing PZT-based DCF scanning endoscope was shared by both modalities [98].…”

Thermo-elastic optical coherence tomography

“…The short deformation accumulation time and the laser-based excitation make it possible to apply TE-OCT for endoscopic imaging at an A-line rate of 50-100 kHz, depending on the time required to capture the transient. Catheter imaging probes are feasible using a doublecladding fiber design [43] and an optimized focusing component [44]. Stacked structures such as multiple absorbing layers will interact through the elasticity of the tissue inducing difficulties in distinguishing.…”

Clinical Applications of Intracoronary OCT (Invited Paper)

“…7). [21][22][23][24] . 또한, CT FFR처럼 OCT lumen contour를 추 출하여 만들어진 3차원 혈관 영상으로부터 전산유체역학 (CFD, computational flow dynamics) 모의시험을 통한 생리 기능적 정보인 sheer stress와 [25] …”