Optical coherence tomography in the diagnosis of bronchial lesions

Tsuboi, Masahiro; Hayashi, Aeru; Ikeda, Norihiko; Honda, Hiroaki; Kato, Yasufumi; Ichinose, Shuji; Kato, Harubumi

doi:10.1016/j.lungcan.2005.04.007

Cited by 160 publications

(110 citation statements)

References 24 publications

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“…OCT can be used to conduct large-volume in vivo microscopy of tissue with resolutions comparable to low-power microscopy (18). OCT has been used to accurately detect and diagnose pathology in vivo for a number of years (17)(18)(19)(20)(21)(22)(23)(24) and has been used to assess the fine microarchitectural features in both normal and pathologic lung (25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43).…”

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confidence: 99%

Diagnosing Lung Carcinomas with Optical Coherence Tomography

et al. 2015

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Rationale: Lung carcinoma diagnosis on tissue biopsy can be challenging because of insufficient tumor and lack of architectural information. Optical coherence tomography (OCT) is a high-resolution imaging modality that visualizes tissue microarchitecture in volumes orders of magnitude larger than biopsy. It has been proposed that OCT could potentially replace tissue biopsy.Objectives: We aim to determine whether OCT could replace histology in diagnosing lung carcinomas. We develop and validate OCT interpretation criteria for common primary lung carcinomas: adenocarcinoma, squamous cell carcinoma (SCC), and poorly differentiated carcinoma.Methods: A total of 82 ex vivo tumor samples were included in a blinded assessment with 3 independent readers. Readers were trained on the OCT criteria, and applied these criteria to diagnose adenocarcinoma, SCC, or poorly differentiated carcinoma in an OCT validation dataset. After a 7-month period, the readers repeated the training and validation dataset interpretation. An independent pathologist reviewed corresponding histology. Measurements and Main Results:The average accuracy achieved by the readers was 82.6% (range, 73.7-94.7%). The sensitivity and specificity for adenocarcinoma were 80.3% (65.7-91.4%) and 88.6% (80.5-97.6%), respectively. The sensitivity and specificity for SCC were 83.3% (70.0-100.0%) and 87.0% (75.0-96.5%), respectively. The sensitivity and specificity for poorly differentiated carcinoma were 85.7% (81.0-95.2%) and 97.6% (92.9-100.0%), respectively. Conclusions:Although these results are encouraging, they indicate that OCT cannot replace histology in the diagnosis of lung carcinomas. However, OCT has potential to aid in diagnosing lung carcinomas as a complement to tissue biopsy, particularly when insufficient tissue is available for pathology assessment.

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confidence: 99%

Diagnosing Lung Carcinomas with Optical Coherence Tomography

et al. 2015

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“…(27) In lung cancer, OCT has been used for differentiating normal mucosa from pre-neoplastic lesions. Three groups of authors (28)(29)(30) studied the tracheobronchial trees of patients suspected of having cancer and compared OCT images with images of biopsy of suspicious sites; the authors concluded that OCT, in addition to being well tolerated, was able to differentiate between normal tissue and tissue with neoplastic infiltration, suggesting that OCT can be an adjuvant technique in the early diagnosis of neoplastic lesions.…”

Section: Discussionmentioning

confidence: 99%

Tomografia de coerência óptica broncoscópica

et al. 2012

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Objective: To evaluate the feasibility of and the potential for using optical coherence tomography in conjunction with conventional bronchoscopy in the evaluation of the airways. Methods: This was a pilot study based on an ex vivo experimental model involving three animals: one adult New Zealand rabbit and two Landrace pigs. An optical coherence tomography imaging catheter was inserted through the working channel of a flexible bronchoscope in order to reach the distal trachea of the animals. Images of the walls of the trachea were systematically taken along its entire length, from the distal to the proximal portion. Results: The imaging catheter was easily adapted to the working channel of the bronchoscope. High-resolution images of cross sections of the trachea were taken in real time, precisely delineating microstructures, such as the epithelium, submucosa, and cartilage, as well as the adventitia of the anterior and lateral tracheal walls. The corresponding layers of the epithelium, mucosa, and cartilage were clearly differentiated. The mucosa, submucosa, and trachealis muscle were clearly identified in the posterior wall. Conclusions: It is feasible to use an optical coherence tomography imaging catheter in combination with a flexible bronchoscope. Optical coherence tomography produces highresolution images that reveal the microanatomy of the trachea, including structures that are typically seen only on images produced by conventional histology.Keywords: Tomography, optical coherence; Trachea; Bronchoscopy; Microscopy; Diagnostic techniques, respiratory system. ResumoObjetivo: Avaliar a viabilidade e o potencial do uso da tomografia de coerência óptica em conjunto com um broncoscópio convencional na avaliação das vias aéreas. Métodos: Estudo piloto baseado em um modelo experimental ex vivo com três animais: um coelho adulto da raça Nova Zelândia e dois suínos da raça Landrace. Um cateter de imagem de tomografia de coerência óptica foi inserido no canal de trabalho de um broncoscópio flexível para alcançarmos a traqueia distal dos animais. As imagens foram obtidas sistematicamente em toda a traqueia ao longo das paredes, partindo da porção distal para a proximal. Resultados: O cateter de imagem se adaptou com facilidade ao canal de trabalho do broncoscópio. Imagens em alta resolução de cortes transversais da traqueia foram obtidas em tempo real, sendo delineadas microestruturas, tais como epitélio, submucosa, cartilagem e camada adventícia nas paredes anteriores e laterais da traqueia. As camadas correspondentes do epitélio, mucosa e cartilagens foram claramente diferenciadas. Na parede posterior, foi possível identificar mucosa, submucosa e musculatura traqueal. Conclusões: O uso de tomógrafo de coerência óptica em conjunto com um broncoscópio flexível é viável. A tomografia de coerência óptica produz imagens de alta resolução que permitem visualizar a microanatomia da traqueia, inclusive estruturas que normalmente são visualizadas somente na histologia convencional.Descritores: Tomografia de coerênc...

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“…Optical coherence tomography has been used to assess the pulmonary airways and parenchyma in animal models [56][57][58][59][60][61] and in vivo human airway. [62][63][64][65][66][67][68] Optical coherence tomography imaging of the normal bronchial wall (Figure 4, A through E) reveals the fine, layered features of the airway, including the epithelium, basement membrane, lamina propria, salivary-type glands and ducts, vessels, and cartilage with surrounding perichondrium. In more distal airways, airway layering and attached lattice-like, signalvoid alveoli can be appreciated.…”

Section: Oct In Pulmonary Imagingmentioning

confidence: 99%

“…In vivo OCT imaging of airway-based carcinomas reveals architectural disorganization of the bronchial layering, segments of mucosa where normal surface maturation is lost, and increased surfaceimage intensity when compared with the underlying tissue. 64,66,67 The ability of OCT to discern preinvasive cancers of the bronchial mucosa has been assessed. 67,68 Lam et al 68 used OCT to evaluate bronchial mucosal lesions identified by autofluorescence bronchoscopy in a group of high-risk smokers.…”

Section: Oct In Pulmonary Imagingmentioning

confidence: 99%

In Vivo Optical Coherence Tomography: The Role of the Pathologist

Hariri

Mino‐Kenudson

Mark

et al. 2012

Archives of Pathology &Amp; Laboratory Medicine

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Optical coherence tomography (OCT) is a nondestructive, high-resolution imaging modality, providing cross-sectional, architectural images at near histologic resolutions, with penetration depths up to a few millimeters. Optical frequency domain imaging is a second-generation OCT technology that has equally high resolution with significantly increased image acquisition speeds and allows for large area, high-resolution tissue assessments. These features make OCT and optical frequency domain imaging ideal imaging techniques for surface and endoscopic imaging, specifically when tissue is unsafe to obtain and/or suffers from biopsy sampling error. This review focuses on the clinical impact of OCT in coronary, esophageal, and pulmonary imaging and the role of the pathologist in interpreting high-resolution OCT images as a complement to standard tissue pathology.

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Optical coherence tomography in the diagnosis of bronchial lesions

Cited by 160 publications

References 24 publications

Diagnosing Lung Carcinomas with Optical Coherence Tomography

Diagnosing Lung Carcinomas with Optical Coherence Tomography

Tomografia de coerência óptica broncoscópica

In Vivo Optical Coherence Tomography: The Role of the Pathologist

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