Optical coherence tomography in the assessment of suspicious oral lesions: An immediate ex vivo study

Hamdoon, Zaid; Jerjes, Waseem; Upile, Tahwinder; McKenzie, Gordon; Jay, Amrita; Hopper, Colin

doi:10.1016/j.pdpdt.2012.07.005

Cited by 61 publications

(49 citation statements)

References 22 publications

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“…These aspects assert the potential capability of OCT in differentiating healthy tissue from cancerous tumors. Our findings are in complete accordance with the study of Wilder-Smith et al 20 and with the study of Hamdoo et al, 21 where it was demonstrated the ability of OCT to separate benign lesions from all other lesion types based on epithelium thickness even though they presented a similar appearance. Extensive epithelial downgrowth and invasion into the sub-epithelial layers.…”

Section: Oct Investigationsupporting

confidence: 93%

Imaging of oral pathological tissue using optical coherence tomography

et al. 2014

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Oral squamous cell carcinoma (OSCC) constitutes 90% of oral cancer. Early detection is a cornerstone to improve survival. Interaction of light with tissues may highlight changes in tissue structure and metabolism. We propose optical coherence tomography (OCT), as a non-invasive diagnosis method, being a new high-resolution optical technique that permits tri-dimensional (3-D), real-time imaging of near surface abnormalities in complex tissues. In this study half of the excisional biopsy was directed to the pathologist and the other half was assigned for OCT investigation. Histopathology validated the results. Areas of OSCC of the buccal mucosa were identified in the OCT images. The elements obserced included extensive epithelial down-growth, the disruption of the basement membrane, with areas of erosion, an epithelial layer that was highly variable in thickness and invasion into the sub-epithelial layers. Therefore, OCT appears to be a highly promising imaging modality.

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Section: Oct Investigationsupporting

confidence: 93%

Imaging of oral pathological tissue using optical coherence tomography

et al. 2014

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“…Considerable histologic distortions created by tissue biopsy and fixation were noted when compared with OCT images of the same region, thus suggesting that in vivo OCT imaging of living tissues may represent a truer biological picture than conventional histopathological analysis. 34,37 (Fig. 2) Since subtle disruption of the BM is the defining characteristic differentiating in situ from invasive carcinoma, this ability of OCT is likely its most significant utility.…”

Section: Optical Coherence Tomographymentioning

confidence: 99%

“…36 Considerable differences of opinion exist between observers of OCT images, and consequently some centers opt to have results reviewed by a pathologist. 37 This could render OCT ineffective in provision of point of care diagnosis if pathology opinion is not immediately available.…”

Section: Optical Coherence Tomographymentioning

confidence: 99%

Point of care optical diagnostic technologies for the detection of oral and oropharyngeal squamous cell carcinoma

et al. 2015

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“…Ex vivo studies have reported the ability of OCT to define cancer boundaries [6], and measure changes in tissue features associated with oral cancer diagnosis such as the thicknesses of the keratin layer, epithelial layer, and lamina propria, as well as identify the continuity of the basement membrane [7][8][9]. Quantitative analysis of the OCT attenuation coefficient in the epithelial layer of formalinfixed biopsy specimens has been employed to discriminate normal from mild, moderate and severe dysplasia with some success [10].…”

Section: Introductionmentioning

confidence: 99%

Wide-field in vivo oral OCT imaging

Lee¹,

Cahill²,

Liu³

et al. 2015

Biomed. Opt. Express

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Abstract:We have built a polarization-sensitive swept source Optical Coherence Tomography (OCT) instrument capable of wide-field in vivo imaging in the oral cavity. This instrument uses a hand-held side-looking fiber-optic rotary pullback catheter that can cover two dimensional tissue imaging fields approximately 2.5 mm wide by up to 90 mm length in a single image acquisition. The catheter spins at 100 Hz with pullback speeds up to 15 mm/s allowing imaging of areas up to 225 mm 2 field-of-view in seconds. A catheter sheath and two optional catheter sheath holders have been designed to allow imaging at all locations within the oral cavity. Image quality of 2-dimensional image slices through the data can be greatly enhanced by averaging over the orthogonal dimension to reduce speckle. Initial in vivo imaging results reveal a wide-field view of features such as epithelial thickness and continuity of the basement membrane that may be useful in clinic for chair-side management of oral lesions. cancer lesion with swept-source optical coherence tomography," J.

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Optical coherence tomography in the assessment of suspicious oral lesions: An immediate ex vivo study

Cited by 61 publications

References 22 publications

Imaging of oral pathological tissue using optical coherence tomography

Imaging of oral pathological tissue using optical coherence tomography

Point of care optical diagnostic technologies for the detection of oral and oropharyngeal squamous cell carcinoma

Wide-field in vivo oral OCT imaging

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