Optical Coherence Tomography in the Gastrointestinal Tract

Brand, Stephan; Poneros, John M.; Bouma, Brett E.; Tearney, G. J.; Compton, Carolyn C.; Nishioka, Norman S.

doi:10.1055/s-2000-7714

Cited by 107 publications

(53 citation statements)

References 40 publications

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“…Although blood and other endogenous substances can limit light penetration into tissue, hemoglobin sometimes provides an important contrast mechanism. Recent advances in optical coherence tomography, which is capable of providing real-time, near-histology resolution of lumenal surfaces at millimeter depths, promises to be particularly effective for carcinoma screening, especially in the GI tract (reviewed in Brand et al 38 and DaCosta et al 39 ).…”

Section: Noncontrast Optical Imaging Of Tissue Surfacesmentioning

confidence: 99%

New Technologies for Human Cancer Imaging

Frangioni

2008

JCO

689

554

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Despite technical advances in many areas of diagnostic radiology, the detection and imaging of human cancer remains poor. A meaningful impact on cancer screening, staging, and treatment is unlikely to occur until the tumor-to-background ratio improves by three to four orders of magnitude (ie, 10 3 -to 10 4 -fold), which in turn will require proportional improvements in sensitivity and contrast agent targeting. This review analyzes the physics and chemistry of cancer imaging and highlights the fundamental principles underlying the detection of malignant cells within a background of normal cells. The use of various contrast agents and radiotracers for cancer imaging is reviewed, as are the current limitations of ultrasound, x-ray imaging, magnetic resonance imaging (MRI), single-photon emission computed tomography, positron emission tomography (PET), and optical imaging. Innovative technologies are emerging that hold great promise for patients, such as positron emission mammography of the breast and spectroscopy-enhanced colonoscopy for cancer screening, hyperpolarization MRI and time-of-flight PET for staging, and ion beam-induced PET scanning and near-infrared fluorescence-guided surgery for cancer treatment. This review explores these emerging technologies and considers their potential impact on clinical care. Finally, those cancers that are currently difficult to image and quantify, such as ovarian cancer and acute leukemia, are discussed. J Clin

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Section: Noncontrast Optical Imaging Of Tissue Surfacesmentioning

confidence: 99%

New Technologies for Human Cancer Imaging

Frangioni

2008

JCO

689

554

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“…Development of scanning catheters has enabled endoscopic OCT imaging of internal organs and extended the OCT study field further [9,10]. Endoscopic OCT imaging has demonstrated its ability to resolve layered tissue structures, and to differentiate normal from certain pathologic conditions within the esophagus [11][12][13][14][15][16], coronary artery [17][18][19] and other internal organs such as the oral cavity [20], larynx [21][22][23], and bladder [24].…”

Section: Introductionmentioning

confidence: 99%

Two-axis magnetically-driven MEMS scanning catheter for endoscopic high-speed optical coherence tomography

Kim¹,

Park²,

Maguluri³

et al. 2007

Opt. Express

158

111

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A two-axis scanning catheter was developed for 3D endoscopic imaging with spectral domain optical coherence tomography (SD-OCT). The catheter incorporates a micro-mirror scanner implemented with microelectromechanical systems (MEMS) technology: the micro-mirror is mounted on a two-axis gimbal comprised of folded flexure hinges and is actuated by magnetic field. The scanner can run either statically in both axes or at the resonant frequency (>= 350Hz) for the fast axis. The assembled catheter has an outer diameter of 2.8 mm and a rigid part of 12 mm in length. Its scanning range is ± 20˚ in optical angle in both axes with low voltages (1~3V), resulting in a scannable length of approximately 1 mm at the surface in both axes, even with the small catheter size. The catheter was incorporated with a multi-functional SD-OCT system for 3D endoscopic imaging. Both intensity and polarization-sensitive images could be acquired simultaneously at 18.5K axial scans/s. In vivo 3D images of human fingertips and oral cavity tissue are presented as a demonstration. Fujimoto, "Scanning single-mode fiber optic catheter-endoscope for optical coherence tomography," Opt. Lett. 21, 543-545 (1996). 26. B. E. Bouma and G. J. Tearney, "Power-efficient nonreciprocal interferometer and linear-scanning fiberoptic catheter for optical coherence tomography," Opt. Lett. 24, 531-533 (1999).

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“…[3][4][5] Existing tissue phantoms, however, while useful for many imaging studies, largely fail to mimic key properties of organs that are visible with endoscopic OCT. For example, one phantom designed for acoustic radiation force-optical coherence elastography of the bladder wall 6 mimics bulk optical properties of the bladder but lacks the multilayered structure that is necessary for OCT to distinguish the cancerous tissue; other characteristic features of the bladder, including its rugged surface texture and macroscale structure [i.e., three-dimensional (3-D) shape], are also missing.…”

Section: Introductionmentioning

confidence: 99%

Three-dimensional, distendable bladder phantom for optical coherence tomography and white light cystoscopy

et al. 2014

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Abstract. We describe a combination of fabrication techniques and a general process to construct a threedimensional (3-D) phantom that mimics the size, macroscale structure, microscale surface topology, subsurface microstructure, optical properties, and functional characteristics of a cancerous bladder. The phantom also includes features that are recognizable in white light (i.e., the visual appearance of blood vessels), making it suitable to emulate the bladder for emerging white light þ optical coherence tomography (OCT) cystoscopies and other endoscopic procedures of large, irregularly shaped organs. The fabrication process has broad applicability and can be generalized to OCT phantoms for other tissue types or phantoms for other imaging modalities. To this end, we also enumerate the nuances of applying known fabrication techniques (e.g., spin coating) to contexts (e.g., nonplanar, 3-D shapes) that are essential to establish their generalizability and limitations. We anticipate that this phantom will be immediately useful to evaluate innovative OCT systems and software being developed for longitudinal bladder surveillance and early cancer detection. © The Authors.Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Optical Coherence Tomography in the Gastrointestinal Tract

Cited by 107 publications

References 40 publications

New Technologies for Human Cancer Imaging

New Technologies for Human Cancer Imaging

Two-axis magnetically-driven MEMS scanning catheter for endoscopic high-speed optical coherence tomography

Three-dimensional, distendable bladder phantom for optical coherence tomography and white light cystoscopy

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