Optical coherence tomography in the 2020s—outside the eye clinic

Chopra, Reena; Wagner, Siegfried; Keane, Pearse A.

doi:10.1038/s41433-020-01263-6

Cited by 56 publications

(43 citation statements)

References 35 publications

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“…With a volume of approximately 1 m 3 and a cost of up to ∼100,000 dollars, an OCT system is, both space and cost-wise, a large investment. Since these parameters are becoming increasingly critical in medical facilities, there is a strong need to lower the costs and miniaturize OCT systems 5 .…”

Section: Introductionmentioning

confidence: 99%

Toward optical coherence tomography on a chip: in vivo three-dimensional human retinal imaging using photonic integrated circuit-based arrayed waveguide gratings

et al. 2021

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In this work, we present a significant step toward in vivo ophthalmic optical coherence tomography and angiography on a photonic integrated chip. The diffraction gratings used in spectral-domain optical coherence tomography can be replaced by photonic integrated circuits comprising an arrayed waveguide grating. Two arrayed waveguide grating designs with 256 channels were tested, which enabled the first chip-based optical coherence tomography and angiography in vivo three-dimensional human retinal measurements. Design 1 supports a bandwidth of 22 nm, with which a sensitivity of up to 91 dB (830 µW) and an axial resolution of 10.7 µm was measured. Design 2 supports a bandwidth of 48 nm, with which a sensitivity of 90 dB (480 µW) and an axial resolution of 6.5 µm was measured. The silicon nitride-based integrated optical waveguides were fabricated with a fully CMOS-compatible process, which allows their monolithic co-integration on top of an optoelectronic silicon chip. As a benchmark for chip-based optical coherence tomography, tomograms generated by a commercially available clinical spectral-domain optical coherence tomography system were compared to those acquired with on-chip gratings. The similarities in the tomograms demonstrate the significant clinical potential for further integration of optical coherence tomography on a chip system.

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Section: Introductionmentioning

confidence: 99%

Toward optical coherence tomography on a chip: in vivo three-dimensional human retinal imaging using photonic integrated circuit-based arrayed waveguide gratings

et al. 2021

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“…It is essential for the cell sheet fabrication process to assess the maturity of samples in an objective and noninvasive approach. Although the application of optical coherence tomography (OCT) shows one possible way to achieve a noninvasive methodology to study the maturity of a cell sheet [28], the cost and size of the instrument, as well as the complexity of the technology have been a barrier for wide accessibility [29]. In this study, the laboratory decided to develop a simple, low-cost, and noninvasive device to measure the transmittance of undifferentiated multilayer ASC cell sheets as an indicator of its maturity and an estimation of the harvesting time that could be used in quality control.…”

Section: Introductionmentioning

confidence: 99%

Measurement of the Adipose Stem Cells Cell Sheets Transmittance

Ochiai¹,

Niihara²,

Oliva³

2021

Bioengineering

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In the field of cell therapy, the interest in cell sheet technology is increasing. To determine the cell sheet harvesting time requires experience and practice, and different factors could change the harvesting time (variability among donors and culture media, between cell culture dishes, initial cell seeding density). We have developed a device that can measure the transmittance of the multilayer cell sheets, using a light emitting diode and a light detector, to estimate the harvesting time. The transmittance of the adipose stromal cells cell sheets (ASCCS) was measured every other day as soon as the cells were confluent, up to 12 days. The ASCCS, from three different initial seeding densities, were harvested at 8, 10, and 12 days after seeding. Real-time PCR and immunostaining confirmed the expression of specific cell markers (CD29, CD73, CD90, CD105, HLA-A, HLA-DR), but less than the isolated adipose stromal cells. The number of cells per cell sheets, the average thickness per cell sheet, and the corresponding transmittance showed no correlation. Decrease of the transmittance seems to be correlated with the cell sheet maturation. For the first time, we are reporting the success development of a device to estimate ASCCS harvesting time based on their transmittance.

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“…322,323 6 Miniaturized, Cost-Effective, and Portable OCT: OCT on a Chip, Home-OCT, and Self-OCT Most commercial OCT devices currently have a footprint of ∼1 2 m and cost up to USD 180.000, which usually inhibits its widespread availability and limits usage of OCT to clinics or large ophthalmic practices. 324 In a typical diagnostic ophthalmic OCT setting, the patient has to remain in an upright position with his head placed on a chin rest and fixating on a target. Certain retinal diseases such as AMD, glaucoma, or diabetic retinopathy require a regular screening to monitor the disease and schedule or monitor therapy.…”

Section: Oct and Deep Learning Neural Network And Artificial Intelligencementioning

confidence: 99%

Enhanced medical diagnosis for dOCTors: a perspective of optical coherence tomography

et al. 2021

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Significance: After three decades, more than 75,000 publications, tens of companies being involved in its commercialization, and a global market perspective of about USD 1.5 billion in 2023, optical coherence tomography (OCT) has become one of the fastest successfully translated imaging techniques with substantial clinical and economic impacts and acceptance.Aim: Our perspective focuses on disruptive forward-looking innovations and key technologies to further boost OCT performance and therefore enable significantly enhanced medical diagnosis.Approach: A comprehensive review of state-of-the-art accomplishments in OCT has been performed. Results:The most disruptive future OCT innovations include imaging resolution and speed (single-beam raster scanning versus parallelization) improvement, new implementations for dual modality or even multimodality systems, and using endogenous or exogenous contrast in these hybrid OCT systems targeting molecular and metabolic imaging. Aside from OCT angiography, no other functional or contrast enhancing OCT extension has accomplished comparable clinical and commercial impacts. Some more recently developed extensions, e.g., optical coherence elastography, dynamic contrast OCT, optoretinography, and artificial intelligence enhanced OCT are also considered with high potential for the future. In addition, OCT miniaturization for portable, compact, handheld, and/or cost-effective capsule-based OCT applications, home-OCT, and self-OCT systems based on micro-optic assemblies or photonic integrated circuits will revolutionize new applications and availability in the near future. Finally, clinical translation of OCT including medical device regulatory challenges will continue to be absolutely essential.Conclusions: With its exquisite non-invasive, micrometer resolution depth sectioning capability, OCT has especially revolutionized ophthalmic diagnosis and hence is the fastest adopted imaging technology in the history of ophthalmology. Nonetheless, OCT has not been completely exploited and has substantial growth potential-in academics as well as in industry. This applies not only to the ophthalmic application field, but also especially to the original motivation of OCT to enable optical biopsy, i.e., the in situ imaging of tissue microstructure with a resolution approaching that of histology but without the need for tissue excision.

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Optical coherence tomography in the 2020s—outside the eye clinic

Cited by 56 publications

References 35 publications

Toward optical coherence tomography on a chip: in vivo three-dimensional human retinal imaging using photonic integrated circuit-based arrayed waveguide gratings

Toward optical coherence tomography on a chip: in vivo three-dimensional human retinal imaging using photonic integrated circuit-based arrayed waveguide gratings

Measurement of the Adipose Stem Cells Cell Sheets Transmittance

Enhanced medical diagnosis for dOCTors: a perspective of optical coherence tomography

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