Optical Coherence Tomography in Respiratory Science and Medicine: From Airways to Alveoli

McLaughlin, Robert A.; Noble, Peter B.; Sampson, David D.

doi:10.1152/physiol.00002.2014

Cited by 28 publications

(18 citation statements)

References 138 publications

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“…It has been especially helpful in measuring airway wall thickness and airway lumen area in patients with asthma and chronic pulmonary obstructive disease (Nakano et al, 2002). A rapidly emerging field is optical coherence tomography, which can be used to study lung structure at a scale of tens of micrometers, including individual alveoli (McLaughlin et al, 2014). Similar to MRI and HRCT, it can be used in vivo, which is a boon to respiratory physiologists and physicians.…”

Section: Magnetic Resonance Imaging and Computed Tomographymentioning

confidence: 99%

Architecture of the Tracheobronchial Tree

Pinkerton

Winkle²,

Plopper

et al. 2015

Comparative Biology of the Normal Lung

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Section: Magnetic Resonance Imaging and Computed Tomographymentioning

confidence: 99%

Architecture of the Tracheobronchial Tree

Pinkerton

Winkle²,

Plopper

et al. 2015

Comparative Biology of the Normal Lung

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“…In the respiratory field, an increasing number of new applications for OCT are emerging 2 . Various endoscopic, needle and bench top OCT systems have been used to measure lumen dimensions in small 3 , large 4, 5 and upper airways 6 , to assess wall morphology and thickness 4, 7 , and to visualise individual alveoli 8 .…”

Section: Introductionmentioning

confidence: 99%

Optical coherence tomography-based contact indentation for diaphragm mechanics in a mouse model of transforming growth factor alpha induced lung disease

Wang

Astell

Wijesinghe

et al. 2017

Sci Rep

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This study tested the utility of optical coherence tomography (OCT)-based indentation to assess mechanical properties of respiratory tissues in disease. Using OCT-based indentation, the elastic modulus of mouse diaphragm was measured from changes in diaphragm thickness in response to an applied force provided by an indenter. We used a transgenic mouse model of chronic lung disease induced by the overexpression of transforming growth factor-alpha (TGF-α), established by the presence of pleural and peribronchial fibrosis and impaired lung mechanics determined by the forced oscillation technique and plethysmography. Diaphragm elastic modulus assessed by OCT-based indentation was reduced by TGF-α at both left and right lateral locations (p < 0.05). Diaphragm elastic modulus at left and right lateral locations were correlated within mice (r = 0.67, p < 0.01) suggesting that measurements were representative of tissue beyond the indenter field. Co-localised images of diaphragm after TGF-α overexpression revealed a layered fibrotic appearance. Maximum diaphragm force in conventional organ bath studies was also reduced by TGF-α overexpression (p < 0.01). Results show that OCT-based indentation provided clear delineation of diseased diaphragm, and together with organ bath assessment, provides new evidence suggesting that TGF-α overexpression produces impairment in diaphragm function and, therefore, an increase in the work of breathing in chronic lung disease.Optical coherence tomography (OCT) is an interferometric imaging technique that forms volumetric images of tissue structure based on contrast generated by the back-scattering of light waves 1 . In the respiratory field, an increasing number of new applications for OCT are emerging 2 . Various endoscopic, needle and bench top OCT systems have been used to measure lumen dimensions in small 3 , large 4, 5 and upper airways 6 , to assess wall morphology and thickness 4,7 , and to visualise individual alveoli 8 . However, one feature of OCT in the respiratory

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“…Several authors have explored the use of OCT for imaging various regions of the airway, both in humans 6, 4, 12 and in animal models 5, 10, 16 . In these studies, aOCT imaging was typically performed under static conditions (for instance at the end of expiration).…”

Section: Introductionmentioning

confidence: 99%

Multi-modal anatomical optical coherence tomography and CT for in vivo dynamic upper airway imaging

Balakrishnan

Price

et al. 2017

SPIE Proceedings

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We describe a novel, multi-modal imaging protocol for validating quantitative dynamic airway imaging performed using anatomical Optical Coherence Tomography (aOCT). The aOCT system consists of a catheter-based aOCT probe that is deployed via a bronchoscope, while a programmable ventilator is used to control airway pressure. This setup is employed on the bed of a Siemens Biograph CT system capable of performing respiratory-gated acquisitions. In this arrangement the position of the aOCT catheter may be visualized with CT to aid in co-registration. Utilizing this setup we investigate multiple respiratory pressure parameters with aOCT, and respiratory-gated CT, on both ex vivo porcine trachea and live, anesthetized pigs. This acquisition protocol has enabled real-time measurement of airway deformation with simultaneous measurement of pressure under physiologically relevant static and dynamic conditions- inspiratory peak or peak positive airway pressures of 10–40 cm H2O, and 20–30 breaths per minute for dynamic studies. We subsequently compare the airway cross sectional areas (CSA) obtained from aOCT and CT, including the change in CSA at different stages of the breathing cycle for dynamic studies, and the CSA at different peak positive airway pressures for static studies. This approach has allowed us to improve our acquisition methodology and to validate aOCT measurements of the dynamic airway for the first time. We believe that this protocol will prove invaluable for aOCT system development and greatly facilitate translation of OCT systems for airway imaging into the clinical setting.

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Optical Coherence Tomography in Respiratory Science and Medicine: From Airways to Alveoli

Cited by 28 publications

References 138 publications

Architecture of the Tracheobronchial Tree

Architecture of the Tracheobronchial Tree

Optical coherence tomography-based contact indentation for diaphragm mechanics in a mouse model of transforming growth factor alpha induced lung disease

Multi-modal anatomical optical coherence tomography and CT for in vivo dynamic upper airway imaging

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