Optical coherence tomography in multiple sclerosis

Siger, Małgorzata; Dziegielewski, K; Jasek, Łukasz; Bieniek, Marek; Nicpan, Agnieszka; Nawrocki, Jerzy; Selmaj, Krzysztof

doi:10.1007/s00415-008-0985-5

Cited by 187 publications

(75 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The investigators have found that in MS, RNFL thickness measured by optical coherence tomography is associated with parenchymal fraction of the brain, cerebral fluid volume, and MS lesion volume [18,19,20]. RNFL thickness was also significantly correlated with fractional anisotropy and radial diffusivity of the connected contralateral optic radiation [21].…”

Section: Discussionmentioning

confidence: 99%

Detailed Illustration of the Visual Field Representation along the Visual Pathway to the Primary Visual Cortex: A Graphical Summary

Wärntges

Michelson²

2013

Ophthalmic Res

View full text Add to dashboard Cite

Purpose: In the literature, different graphic illustrations are available, which depict different parts of the visual pathway in relation to visual field sectors, to retinal sectors, the layers of the lateral geniculate nucleus (LGN), or sections of the primary visual cortex (V1). However, a complete overview is missing, which may be useful for a more precise differentiation of predominantly ophthalmological from intracerebral diseases. It may also be of interest to investigate additional intracerebral reasons that are involved in impaired vision of largely unknown pathophysiology. Methods: This work combines the scientific knowledge of partial graphics in one detailed illustration that allows exact follow-up of the neuronal connections from individual visual field sectors to the V1 areas. A selective search for peer-reviewed graphics of the visual pathway was performed in PubMed and Google Pictures. Results: Sixteen different visual field sectors and their 16 corresponding retinal sectors were set in relation to 64 LGN sections and 20 areas of V1. Segmented cross-sectional areas of the optic nerve supplemented the graphical representation of the fiber orientation in relation to the visual field. Conclusion: The detailed illustration of the visual field projection along the visual pathway structures may facilitate a more precise calculation of correlations between morphological and functional measurements of ophthalmological and neuroradiological examinations.

show abstract

Section: Discussionmentioning

confidence: 99%

Detailed Illustration of the Visual Field Representation along the Visual Pathway to the Primary Visual Cortex: A Graphical Summary

Wärntges

Michelson²

2013

Ophthalmic Res

View full text Add to dashboard Cite

show abstract

“…In this respect, it has been reported that RNFL thinning is associated not only with demyelinating diseases involving optic nerve such as multiple sclerosis but also with primary neurodegenerative disorders in which visual deficits are less relevant [8,9,10]. …”

Section: Discussionmentioning

confidence: 99%

Retinal Nerve Fiber Layer Thinning in CADASIL: An Optical Coherence Tomography and MRI Study

Rufa¹,

Pretegiani²,

Frezzotti

et al. 2010

Cerebrovasc Dis

View full text Add to dashboard Cite

Background and Purpose: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is considered a genetic form of small-vessel disease causing subcortical dementia. A relevant role of axonal injury was recently proposed to explain disability and cognitive decline in this disease. The retinal nerve fiber layer (RNFL) is the only part of the brain where unmyelinated axons can be visualized and quantified in vivo. Their assessment may be an easily reproducible marker of neurodegenerative processes. The aim of this study was to investigate axonal degeneration in CADASIL by measuring RNFL thickness and correlating it with MRI measures of global and regional cerebral atrophy. Methods: RNFL thickness was measured using optical coherence tomography in 17 CADASIL patients. Average values per quadrant (temporal, superior, nasal, inferior) and overall values were compared with those of normal sex- and age-matched subjects. Data of 13 patients were analyzed for correlations with MRI-based global and regional brain volumes normalized for head size. Results: RNFL thickness was significantly reduced in CADASIL patients with respect to controls (p < 0.05). No significant correlations were found between RNFL thinning and brain atrophy. Conclusions: RNFL thinning suggests that retinal axonal loss occurs in CADASIL, even in the absence of subjective visual deficit.

show abstract

“…Petzold A et al [14] meta-analyzed 12 studies regarding RNFL in eyes with multiple sclerosis optic neuritis (MS ON) [12,[15][16][17][18][19][20][21][22][23][24] . They observed significant average RNFL loss -20.38 µm in MSON eyes (95% CI, -22.86 to -17.91).…”

Section: Discussionmentioning

confidence: 99%

Prognostic determination using optical coherence tomography compared with visual functions in optic neuritis

Kitthaweesin

Sutra

2013

JBGC

View full text Add to dashboard Cite

Background: The majority of optic neuritis patients often notice improvement and gain stability of their visual functions, however, evidences of ongoing retinal nerve fiber layer (RNFL) thinning have been reported. Purposes:To investigate the correlation between RNFL thickness measured with Optical coherence tomography (OCT) and visual function tests and to determine the utility of OCT in visual prognostic assessment of optic neuritis. Method:A prospective study was performed in 12 patients with acute isolated optic neuritis. Best corrected visual acuity (BCVA), Swedish interactive threshold algorithms (SITA) 30-2 strategy on Humphrey field analyzer, and fast RNFL thickness analysis were performed on both affected and fellow eyes at baseline, 1.5, three and six months.Results: Mean BCVA and average mean deviation (MD) of the affected eye were significantly different from the fellow eyes at baseline. Affected eyes had significant thinner of RNFL at baseline, 1.5, three, and six months. Significant correlations between (i) mean RNFL thickness and BCVA at 1.5 (r = 0.707, p = .010), (ii) mean RNFL thickness and MD at 1.5 months (r = 0.674, p = .016) and six months(r = 0.710, p = .032), (iii) mean RNFL thickness at 1.5 months and MD at six months (r = 0.782, p = .013). Conclusion:A correlation between RNFL thickness and visual function tests indicates that OCT might have roles in detection and prediction of RNFL damage in Optic neuritis (ON) patients despite no evidence of MS.

show abstract

Optical coherence tomography in multiple sclerosis

Abstract: The RNFL measured by OCT may be useful as a surrogate marker for assessment of brain atrophy in MS.

Cited by 187 publications

References 22 publications

Detailed Illustration of the Visual Field Representation along the Visual Pathway to the Primary Visual Cortex: A Graphical Summary

Detailed Illustration of the Visual Field Representation along the Visual Pathway to the Primary Visual Cortex: A Graphical Summary

Retinal Nerve Fiber Layer Thinning in CADASIL: An Optical Coherence Tomography and MRI Study

Prognostic determination using optical coherence tomography compared with visual functions in optic neuritis

Contact Info

Product

Resources

About