Optical Coherence Tomography in Biophotonics

Drexler, Wolfgang; Andersen, Peter E.

doi:10.1002/jbio.200910542

Cited by 4 publications

(4 citation statements)

References 17 publications

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“…It was made sure that only those data points were used for fitting up to which the decay/amplitude was zero. The goodness of fit metric (fitting parameter, r 2 ) was 0.97 and ~0.98 for sample set (1 and 2), respectively, in case of mono exponential fitting while r 2 ~ 0.97 for sample set (3). Therefore, double exponential fitting was significantly larger than ~ 0.82 (mono exponen …”

Section: Signal Processing: Autocorrelationmentioning

confidence: 93%

“…(b) The time frame difference between 1400 frames recorded in a total time of five milliseconds that were strictly observed not to cross six milliseconds. The figure is for typical sample of 80 mM NaCl concentration in whole blood phantom set(3).…”

mentioning

confidence: 99%

“…Optical coherence tomography OCT which is a promising novel technique based on the principle of optical interferometry [2][3][4][5] is capable to yield micron scale resolution subsurface imaging of tissues giving detailed information of biological structures and provides access to many body sites enabled by fiber optics implementation [6]. These OCT studies attempted for quantification of glucose due to change in refractive index matching effect [7,8] can be imple mented for monitoring the salt concentrations in flu ids/blood.…”

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confidence: 99%

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M-mode swept source optical coherence tomography for quantification of salt concentration in blood: An in vitro study

et al. 2012

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We report the use of M mode swept source optical coherence tomography (SS OCT) for measur ing sodium chloride (NaCl) salt concentrations in liquid phantoms and in drawn whole blood based on tem poral dynamics of light scattering. The Brownian motion of scattering particle is affected due to the change in viscosity of liquid. An autocorrelation function was determined from the power spectrum of SS OCT signal and then was fit by mono and double exponential function to obtain decorrelation time. These translational decorrelation times corresponding to translational diffusion coefficients enabled us to find the controlled vis cosity of the medium. The viscosities of the media were compared with literature values and a fair/excellent agreement was observed. Thus, the technique has ability to quantify the salt levels in terms of viscosity in non flowing medium suspensions and many research routes necessary to determine its potential for in vivo appli cations.

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Section: Signal Processing: Autocorrelationmentioning

confidence: 93%

mentioning

confidence: 99%

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confidence: 99%

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M-mode swept source optical coherence tomography for quantification of salt concentration in blood: An in vitro study

et al. 2012

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“…Different type of human tissues have been differentiated among normal and malignant using OCT [4][5][6]. Generally, these techniques [7] utilized the high numerical aperture (NA) refractive objective lens for achieving fine lateral resolution that leads to loss in depth-of-field (DOF) of the sample beam. A typical 20x lens with 0.4 NA having only ~6µm DOF.…”

Section: Introductionmentioning

confidence: 99%

Common-path optical coherence tomography using Bessel beam axicon probe for malignancy identification

Gupta¹,

Vairagi²,

Sharma³

et al. 2023

Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII

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The ability to detect the malignancy inside the tissue structure non-invasively have immense potential in the clinical application. In this work, a Bessel beam axicon probe based common-path optical coherence tomography system is demonstrated for detection of malignancy inside the human tissue. This probe is employed in this system having an axicon structure which is chemically etched inside the optical fiber end. This probe generates a quality Bessel beam owning a large depth-of-field, ~700µm and small central spot size. This probe effectively identifies the malignancy in the human colon tissue hence it could be a great tool as an endoscopic probe in future for either early-stage or during surgery diagnosis.

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Optical coherence tomography in dermatology: technical and clinical aspects

2011

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Optical coherence tomography (OCT), a fairly new non-invasive optical real-time imaging modality, is an emergent in vivo technique, based on the interference (Michelson interferometry) of infrared radiation and living tissues, that allows high-resolution, 2- or 3-dimensional, cross-sectional visualisation of microstructural morphology of tissues. OCT provides depth-resolved images of tissues with resolution up to a few micrometers and depth up to several millimetres depending on tissue type. The investigations using OCT to assess skin structure in clinical settings started in the past decade and consequently proved that this imaging method is useful in visualizing subsurface structures of normal skin, including the epidermis, dermoepidermal junction, dermis, hair follicles, blood vessels and sweat ducts. An increasing number of papers brought evidence of the utility and the precision of OCT technology, in its different technical variants, in diagnosing and monitoring skin disorders, including malignancies and inflammatory conditions, respectively. The present comprehensive review describes and illustrates technical aspects and clinical applications of OCT methods in dermatology.

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Optical Coherence Tomography in Biophotonics

Cited by 4 publications

References 17 publications

M-mode swept source optical coherence tomography for quantification of salt concentration in blood: An in vitro study

M-mode swept source optical coherence tomography for quantification of salt concentration in blood: An in vitro study

Common-path optical coherence tomography using Bessel beam axicon probe for malignancy identification

Optical coherence tomography in dermatology: technical and clinical aspects

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