Optical Coherence Tomography Imaging of Presumed Sarcoid Retinal and Optic Nerve Nodules

Goldberg, Naomi R.; Jabs, Douglas A.; Busingye, Jacqueline

doi:10.3109/09273948.2014.971972

Cited by 10 publications

(10 citation statements)

References 7 publications

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“…5 There was been one other report of the use of OCT to investigate optic nerve head granuloma. 28 In the two cases reported, the granulomas were associated with peripapillary retinal oedema, as in the present case, although one of these cases had choroidal inflammation as well. Follow-up OCT was carried out after 12 months in one case demonstrating normalisation of the peripapillary outer retinal layers and decreased optic nerve head height with the development of optic nerve head gliosis.…”

Section: Discussionmentioning

confidence: 52%

The Evolution of an Optic Nerve Head Granuloma Due to Sarcoidosis

Hickman

Quhill

Pepper

2016

Neuro-Ophthalmology

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Sarcoidosis can affect the optic nerves by means of optic disc oedema secondary to posterior uveitis, optic disc oedema secondary to raised intracranial pressure, optic neuritis, optic atrophy secondary to compression or infiltration from a primary central nervous system lesion, and primary granuloma of the optic nerve head. The authors report the use of optical coherence tomography in assessing the response to immunosuppression in a 57-year-old woman with an optic nerve head granuloma. ARTICLE HISTORY

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Section: Discussionmentioning

confidence: 52%

The Evolution of an Optic Nerve Head Granuloma Due to Sarcoidosis

Hickman

Quhill

Pepper

2016

Neuro-Ophthalmology

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“…Indeed, the granuloma in this case seems to share some OCT features with the intraretinal granulomas of sarcoidosis, including nodular hyperreflectivity and protrusion into the vitreous cavity. However, intraretinal sarcoid granulomas are often associated with distortion of the adjacent retinal architecture 5,6 —a feature which, again, is largely absent in the OCT images presented here. To the authors' knowledge, this is the first report to include OCT images of an NFL-based intraretinal tuberculoma in the English language literature and only the second such report of an NFL-based lesion.…”

Section: Discussionmentioning

confidence: 59%

Multimodal Imaging of an Intraretinal Tubercular Granulomatous Neuroretinitis

Lyons

Singh

Carvounis

et al. 2020

RETINAL Cases &Amp; Brief Reports

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Purpose:To report a rare case of an intraretinal tuberculoma and associated neuroretinitis.Methods:The patient was evaluated with various imaging modalities including fundus photography, fluorescein angiography, magnetic resonance imaging, and optical coherence tomography; her extensive laboratory workup returned positive for tuberculosis.Results:After initially presenting with no light perception, 13 weeks of antitubercular therapy allowed for visual acuity recovery to 20/30.Conclusion:We demonstrate the spectral domain optical coherence tomography characteristics of an intraretinal tuberculoma.

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“…Uveitic lesions would be expected to demonstrate a more uniform reflectivity on OCT and would not be expected to arise from the Bruch membrane/RPE complex. 12,13 Retinal pigment epithelium neoplasms are rare. These lesions demonstrate minimal risk for metastasis but can show local invasion into the overlying retina, acquire feeding retinal vasculature, and induce an exudative response.…”

Section: Discussionmentioning

confidence: 99%

Atypical Congenital Hypertrophy of the Retinal Pigment Epithelium Complicated by Presumed Retinal Pigment Epithelial Adenoma and Exudative Maculopathy

Mehta

Gal-Or

Barbazetto

et al. 2021

RETINAL Cases &Amp; Brief Reports

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Purpose: To report a retinal pigment epithelium (RPE) tumor with exudative maculopathy, originating from an atypical RPE lesion presumed to represent congenital hypertrophy of the RPE or RPE hyperplasia.Methods: Multimodal imaging including fundus autofluorescence, optical coherence tomography, fluorescein angiography, and optical coherence tomography angiography.Results: A 76-year-old West African man noted visual acuity reduction to count fingers in the right eye and 20/400 in the left eye. Features of chronic glaucoma were noted. In addition, there was a fairly well-circumscribed darkly pigmented RPE lesion in the paramacular region in the right eye, measuring 4 mm in diameter and flat and consistent with atypical congenital hypertrophy of the RPE or RPE hyperplasia. On the posterior margin of this mass was an RPE tumor, presumed to represent RPE adenoma, producing exudative maculopathy and cystoid macular edema. Multimodal imaging was used to distinguish the RPE tumor from macular neovascularization. A similar atypical congenital hypertrophy of the RPE without retinopathy measuring 3.5mm in diameter was noted in the temporal macular region in the left eye. After six monthly doses of intravitreal bevacizumab (1.25 mg/0.05 mL) in the right eye, the maculopathy resolved and the RPE mass showed partial involution with visual acuity return to baseline 20/200.Conclusion: Congenital hypertrophy of the RPE and RPE hyperplasia can produce RPE adenoma with related exudative maculopathy. In this case, the maculopathy responded to bevacizumab.

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Optical Coherence Tomography Imaging of Presumed Sarcoid Retinal and Optic Nerve Nodules

Abstract: Spectral OCT can be useful in identifying lesion morphology and location, and in tracking the response to treatment in eyes with posterior-segment nodules, presumably secondary to sarcoidosis.

Cited by 10 publications

References 7 publications

The Evolution of an Optic Nerve Head Granuloma Due to Sarcoidosis

The Evolution of an Optic Nerve Head Granuloma Due to Sarcoidosis

Multimodal Imaging of an Intraretinal Tubercular Granulomatous Neuroretinitis

Atypical Congenital Hypertrophy of the Retinal Pigment Epithelium Complicated by Presumed Retinal Pigment Epithelial Adenoma and Exudative Maculopathy

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