Optical Coherence Tomography–Guided Decisions in Retinoblastoma Management

Vision and visual potential for perifoveal retinoblastoma after optical coherence tomographic-guided sequential laser photocoagulation

“…We developed a sequential fovea-sparing laser technique2 for central tumours with a tumour-free area within a 2 DD circle centred over the fovea. The initial antifoveal laser barrier is hypothesised to block the tumour blood supply resulting in tumour death and shrinkage, assuming that the foveal avascular zone would not contribute blood supply to the nearby tumour.…”

“…OCT surveillance delineated flat scars that needed no more treatment and facilitated timely detection of subclinical (otherwise invisible) tumour recurrences. OCT differentiates between gliosis and tumour recurrence, preventing unnecessary treatment of inactive lesions 2. However, the hand-held OCT does not have built-in functionality to map macular thickness; we recorded as a surrogate for macular health, preservation of the photoreceptor IS–OS junction.…”

“…Retinoblastoma management has recently evolved to include precision diagnostic and therapeutic tools including molecular diagnosis,1 optical coherence tomography (OCT),2 intravitreal chemotherapy3 4 and intra-arterial chemotherapy (IAC),5 6 resulting in increased eye salvage and potential for vision.…”

Conservative treatment of diffuse infiltrating retinoblastoma: optical coherence tomography-assisted diagnosis and follow-up in three consecutive cases

“…On top of the biallelic RB1 gene inactivation, the authors hypothesised a subsequent hit modifying the tumour cells adhesion properties that could then drive the specific growth pattern 19. Interestingly, OCT of typical rb forms showed involvement of the inner16 or the outer nuclear layer17 but not the ganglion cell layer, thus raising the question of distinct cells-of-origin. Further studies are however needed to establish those assumptions.…”

Retinoblastoma, the visible CNS tumor: A review

“…However, OCT does have limitations: it images the periphery of the retina poorly (although technology for widefield OCT is improving), and it relies on transparent media; large tumors and/or cataracts limit its usefulness. Despite this, OCT for retinoblastoma is usually successful and can guide treatment decisions (Soliman, VandenHoven, et al, ). With time, OCT will doubtless assume a greater role in the staging and management of retinoblastoma, taking true advantage of the accessibility of the eye to manage this cancer.…”