Optical Coherence Tomography for the Radiologist

Schiffman, Jade S.; Patel, Nimesh B.; Cruz, Roberto Alejandro; Tang, Rosa A.

doi:10.1016/j.nic.2015.05.002

Cited by 6 publications

(3 citation statements)

References 46 publications

(44 reference statements)

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“…1). ( 18 ) In compressive nerve injuries, OCT RNFL imaging has emerged as a potential diagnostic and prognostic tool for ON and visual recovery, respectively. ( 19–21 ) OCT is used to monitor for progressive visual deterioration in several diseases and has been shown to detect changes in RNFL thickness before functional vision loss.…”

Section: Introductionmentioning

confidence: 99%

Utility of Optical Coherence Tomography in the Diagnosis and Management of Optic Neuropathy in Patients with Fibrous Dysplasia

Pan

FitzGibbon

Vitale

et al. 2020

Journal of Bone and Mineral Research

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Optic neuropathy (ON) is a highly disabling complication of fibrous dysplasia (FD). The optimal test for identifying and monitoring ON in FD is unknown. Optical coherence tomography (OCT) is an imaging modality that detects retinal nerve fiber layer (RNFL) thinning, a sign of optic nerve atrophy. The purpose of this study was to (i) assess the ability of OCT RNFL thickness measurements to identify ON in FD; (ii) compare the performance of RNFL thickness to computed tomography measurements; and (iii) examine changes in RNFL thickness over time to assess disease progression. A retrospective cohort study was performed to assess subjects (n = 70) who underwent neuro-ophthalmologic examination, including OCT. The diagnostic utility of RNFL thickness was determined using receiver operator characteristic (ROC) curve analysis, and the accuracy was compared with computed tomography measurements. The relationship between RNFL thickness and age was assessed cross-sectionally, using generalized estimating equation methodology, and longitudinally, using a generalized mixed model. Eleven subjects were identified with ON. RNFL thickness identified ON (area under curve = 0.997, p < 0.0001) with sensitivity and specificity of 100% and 95%, respectively, when using the diagnostic criterion of ≤71 μm. RNFL thickness outperformed computed tomography measurements of optic canal narrowing and optic nerve stretch. Subjects with ON exhibited a greater decrease in RNFL thickness with each year of age (−0.70 μm/year, p < 0.001) than subjects with normal vision (−0.16 μm/year, p < 0.05). When assessed longitudinally, subjects with normal vision demonstrated an increase in RNFL thickness until approximately age 20 years that decreased thereafter. In contrast, subjects with ON exhibited an earlier decrease in RNFL thickness during adolescence. In conclusion, RNFL thickness of ≤71 μm accurately identified ON in this population. By establishing the difference in rate of RNFL thinning in patients with and without ON, clinicians may distinguish between patients at risk for ON and intervene before irreversible damage.

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Section: Introductionmentioning

confidence: 99%

Utility of Optical Coherence Tomography in the Diagnosis and Management of Optic Neuropathy in Patients with Fibrous Dysplasia

Pan

FitzGibbon

Vitale

et al. 2020

Journal of Bone and Mineral Research

View full text Add to dashboard Cite

show abstract

“…The compressed archives of OCT imaging contain 128 individual OCT B-scans, one of a handful of imaging types that OCT devices can produce (only OCT B-scans are available in UKBB). Readers are directed to comprehensive reviews and textbooks about the technical specifications of how OCT imaging is captured (Abràmoff et al, 2010;Aumann et al, 2019;Dahrouj et al, 2022;Schiffman et al, 2015); in sum, data about the speed at which light is reflected against the retina allows for quantification of retinal morphology. Eighteen-thousand A-scans (i.e., a single cross-sectional image of the retina) are collected per second during OCT imaging with the Topcon 3D OCT1000…”

Section: Retinal Imaging Data Preparationmentioning

confidence: 99%

“…UKBB collected "3-dimensional macular volume scans" which are 3D B-scans centered on the macular region of the retina (Ko, 2019;Ko et al, 2017, p. 106). OCT imaging devices are able to capture images centered on the macula or the optic nerve (Schiffman et al, 2015), however, the biophysiological features of the macula makes it a compelling region for study. The macula is the center of the retina and the primary optical structure that produces high visual acuity in humans and other primates (Provis et al, 2005).…”

Section: Retinal Imaging Data Preparationmentioning

confidence: 99%