Optical coherence tomography detects structural abnormalitiesof the nasal mucosa in patients with cystic fibrosis

Oltmanns, Ute; Palmowski, Karin; Wielpütz, Mark O.; Kahn, Nicolas; Baroke, Eva; Eberhardt, Ralf; Wege, Sabine; Wiebel, M.; Kreuter, Michael; Herth, Felix; Mall, Marcus

doi:10.1016/j.jcf.2015.07.003

Cited by 20 publications

(14 citation statements)

References 25 publications

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“…In this context, a previous study indicated MRI may constitute an attractive tool for sensitive detection and non‐invasive monitoring of characteristic structural abnormalities of upper airways in children with CF . This notion is supported by preliminary studies conducted at our CF center demonstrating that MRI is sensitive to detect mucosal thickening in the paranasal sinuses even in infants and preschool children with CF (Fig. ).…”

Section: Mri For Monitoring Of Upper Airways Disease In Cfsupporting

confidence: 54%

“…In addition to lower airways disease, CFTR dysfunction causes chronic mucoobstructive disease of the upper airways characterized by mucus retention, infection and inflammation in the paranasal sinuses, and nasal cavity, often accompanied by the development of nasal polyps that may aggravate local mucociliary dysfunction and airflow obstruction Clinically, CF upper airways disease presents as chronic rhinosinusitis that is almost invariably present from early childhood . Compared to our current understanding of early lung disease, little is known about the onset and spontaneous progression of upper airways disease in children with CF.…”

Section: Mri For Monitoring Of Upper Airways Disease In Cfmentioning

confidence: 99%

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Early detection and sensitive monitoring of CF lung disease: Prospects of improved and safer imaging

Mall

Stahl

Graeber

et al. 2016

Pediatric Pulmonology

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Summary. Recent imaging studies using chest computed tomography (CT) in presymptomatic infants and young children with cystic fibrosis (CF) diagnosed by newborn screening presented compelling evidence of early onset and progression of structural lung damage in CF. These data argue persuasively that non-invasive outcome measures for early detection and sensitive monitoring of lung disease applicable in the clinical setting will be instrumental for further improvement of clinical care and the development of early intervention therapies that have the potential to prevent irreversible lung damage. In this context, the use of CT imaging for early detection and long-term monitoring has the disadvantage of the risk to induce malignancies due to cumulating ionizing radiation exposure. More recently, magnetic resonance imaging (MRI) has emerged as an alternative radiation-free imaging technique for quantitative assessment of CF lung disease. In addition to structural lung damage, chest MRI enables non-invasive assessment of abnormalities in lung perfusion and ventilation characteristically associated with mucus plugging in CF lung disease. Here, we review recent developments and the prospects of MRI for improved and safer imaging with a focus on recent studies that support its utility as a sensitive non-invasive outcome measure of early lung disease in young children with CF. Pediatr Pulmonol. 2016;51:S49-S60.

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Section: Mri For Monitoring Of Upper Airways Disease In Cfsupporting

confidence: 54%

Section: Mri For Monitoring Of Upper Airways Disease In Cfmentioning

confidence: 99%

Early detection and sensitive monitoring of CF lung disease: Prospects of improved and safer imaging

Mall

Stahl

Graeber

et al. 2016

Pediatric Pulmonology

Self Cite

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“…In addition to these lab-based future directions, data generated about injury and regeneration to ciliated surfaces provides further motivation to the ongoing development of endoscopic/bronchoscopic in vivo OCT technologies (e.g. 26 , 27 ) for the potential longitudinal imaging of the injured tracheal mucosa in the ICU. In conclusion, utilizing multi-contrast OCT allows a multi-faceted investigation of injury to the ciliated epithelium by combining (a) PTV for a quantitative flow analysis with (b) 3D rendered speckle-variance imaging for visualization of ciliary patches.…”

Section: Discussionmentioning

confidence: 99%

Visualization and quantification of injury to the ciliated epithelium using quantitative flow imaging and speckle variance optical coherence tomography

Gamm

Huang

Mis

et al. 2017

Sci Rep

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Mucociliary flow is an important defense mechanism in the lung to remove inhaled pathogens and pollutants. Disruption of ciliary flow can lead to respiratory infections. Multiple factors, from drugs to disease can cause an alteration in ciliary flow. However, less attention has been given to injury of the ciliated epithelium. In this study, we show how optical coherence tomography (OCT) can be used to investigate injury to the ciliated epithelium in a multi-contrast setting. We used particle tracking velocimetry (PTV-OCT) to investigate the cilia-driven flow field and 3D speckle variance imaging to investigate size and extent of injury caused to the skin of Xenopus embryos. Two types of injuries are investigated, focal injury caused by mechanical damage and diffuse injury by a calcium chloride shock. We additionally investigate injury and regeneration of cilia to calcium chloride on ex vivo mouse trachea. This work describes how OCT can be used as a tool to investigate injury and regeneration in ciliated epithelium.

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“…A few ex vivo studies reported on the application of OCT for analysing wall degradation in aortic aneurysms [RVBR*14, OPW*16]. The dynamic motion of the inner vessel wall has been related to the underlying pulsatile flow [LDE14, KPG*16a].…”

Section: Flow Data Generation Pipelinementioning

confidence: 99%

Generation and Visual Exploration of Medical Flow Data: Survey, Research Trends and Future Challenges

Oeltze-Jafra

Meuschke

Neugebauer

et al. 2018

Computer Graphics Forum

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Simulations and measurements of blood and airflow inside the human circulatory and respiratory system play an increasingly important role in personalized medicine for prevention, diagnosis and treatment of diseases. This survey focuses on three main application areas. (1) Computational fluid dynamics (CFD) simulations of blood flow in cerebral aneurysms assist in predicting the outcome of this pathologic process and of therapeutic interventions. (2) CFD simulations of nasal airflow allow for investigating the effects of obstructions and deformities and provide therapy decision support. (3) 4D phase‐contrast (4D PC) magnetic resonance imaging of aortic haemodynamics supports the diagnosis of various vascular and valve pathologies as well as their treatment. An investigation of the complex and often dynamic simulation and measurement data requires the coupling of sophisticated visualization, interaction and data analysis techniques. In this paper, we survey the large body of work that has been conducted within this realm. We extend previous surveys by incorporating nasal airflow, addressing the joint investigation of blood flow and vessel wall properties and providing a more fine‐granular taxonomy of the existing techniques. From the survey, we extract major research trends and identify open problems and future challenges. The survey is intended for researchers interested in medical flow but also more general, in the combined visualization of physiology and anatomy, the extraction of features from flow field data and feature‐based visualization, the visual comparison of different simulation results and the interactive visual analysis of the flow field and derived characteristics.

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Optical coherence tomography detects structural abnormalitiesof the nasal mucosa in patients with cystic fibrosis

Abstract: OCT detected mucosal changes associated with upper airway inflammation and response to antibiotic therapy in CF patients. OCT may be a useful tool for quantitative in vivo assessment of structural changes of the airway mucosa.

Cited by 20 publications

References 25 publications

Early detection and sensitive monitoring of CF lung disease: Prospects of improved and safer imaging

Early detection and sensitive monitoring of CF lung disease: Prospects of improved and safer imaging

Visualization and quantification of injury to the ciliated epithelium using quantitative flow imaging and speckle variance optical coherence tomography

Generation and Visual Exploration of Medical Flow Data: Survey, Research Trends and Future Challenges

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